ID   LRC41_PONAB             Reviewed;         812 AA.
AC   Q5R9H2; Q5R791;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Leucine-rich repeat-containing protein 41;
GN   Name=LRRC41;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate recognition component of an ECS (Elongin
CC       BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates
CC       the ubiquitination and subsequent proteasomal degradation of target
CC       proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of an E3 ubiquitin-protein ligase complex with Elongin BC
CC       (ELOB and ELOC), RBX1 and CUL5. Component of a probable ECS(LRRC41)
CC       complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41.
CC       Interacts with CUL5, RNF7, ELOB and ELOC (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: The Elongin BC complex binding domain is also known as BC-box
CC       with the consensus [APST]-L-x(3)-C-x(3)-[AILV]. {ECO:0000250}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-23 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH92369.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CR859416; CAH91588.1; -; mRNA.
DR   EMBL; CR860227; CAH92369.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001125935.1; NM_001132463.1.
DR   AlphaFoldDB; Q5R9H2; -.
DR   SMR; Q5R9H2; -.
DR   STRING; 9601.ENSPPYP00000001619; -.
DR   GeneID; 100172869; -.
DR   KEGG; pon:100172869; -.
DR   CTD; 10489; -.
DR   InParanoid; Q5R9H2; -.
DR   OrthoDB; 322569at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR026137; Leu_rpt_41.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR15354; PTHR15354; 1.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..812
FT                   /note="Leucine-rich repeat-containing protein 41"
FT                   /id="PRO_0000292658"
FT   REPEAT          487..507
FT                   /note="LRR 1"
FT   REPEAT          518..530
FT                   /note="LRR 2"
FT   REPEAT          531..555
FT                   /note="LRR 3"
FT   REPEAT          613..635
FT                   /note="LRR 4"
FT   REPEAT          636..659
FT                   /note="LRR 5"
FT   REPEAT          701..728
FT                   /note="LRR 6"
FT   REPEAT          731..752
FT                   /note="LRR 7"
FT   REGION          45..54
FT                   /note="Interaction with Elongin BC complex"
FT                   /evidence="ECO:0000250"
FT   REGION          268..408
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..379
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         155
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15345"
FT   MOD_RES         276
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15345"
FT   MOD_RES         326
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15345"
FT   MOD_RES         327
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15345"
FT   MOD_RES         357
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15345"
FT   MOD_RES         373
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15345"
FT   CONFLICT        482
FT                   /note="R -> H (in Ref. 1; CAH92369)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        497
FT                   /note="F -> Y (in Ref. 1; CAH92369)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   812 AA;  88623 MW;  362E250C08350D1F CRC64;
     MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP NAPPALFELC GRAVSAHMGV
     LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ AIWRRLWDEL MKTRPSSLES
     VTCWRAKFME AFFSHVLRGT IDVSSDRRLC DQRFSPLLHS SRHVRQLTIC NMLQGATELV
     AEPNRRVLET LASSLHTLKF RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES
     ALFILILTMS AGFWQPGPGG PPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA
     LMASRRKSEA KQMPRAAPAA RVTRRSTQES LTAGGTDLKR ELHPPATSHE APGTKRSPSA
     PAATSSASSS TSSYKRAPAS SAPQPKPLKR FKRAAGKKGA RTRQGPGAES EDLYDFVFIV
     AGEKEDGEEM EIGEVACGAL DGSDPSCLGL PALEASQRFR SISTLELFTV PLSTEAALTL
     CRLLSSWVSL ESLTLSFNGL GSNIFRLLDS LRALSGQAGC RLRALHLSDL FSPLPILELT
     RAIVRALPLL RVLSIRVDHP SQRDNPGVPG NAGPPSHIIG DEEIPENCLE QLEMGFPRGA
     QPAPLLCSVL KASGSLQQLS LDSATFASPQ DFGLVLQTLK EYNLALKRLS FHDMNLADCQ
     SEVLFLLQNL TLQEITFSFC RLFEKRPAQF LPEMVAAMKG NSTLKGLRLP GNRLGNAGLL
     ALADVFSEDS SSSLCQLDIS SNCIKPDGLL EFAKRLERWG RGAFGHLRLF QNWLDQDAVT
     AREAIRRLRA TCHVVSDSWD SSQAFADYVS TM