LRC41_RAT
ID LRC41_RAT Reviewed; 808 AA.
AC Q5M9H1;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Leucine-rich repeat-containing protein 41;
GN Name=Lrrc41;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable substrate recognition component of an ECS (Elongin
CC BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates
CC the ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of an E3 ubiquitin-protein ligase complex with Elongin BC
CC (ELOB and ELOC), RBX1 and CUL5. Component of a probable ECS(LRRC41)
CC complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41.
CC Interacts with CUL5, RNF7, ELOB and ELOC (By similarity).
CC {ECO:0000250}.
CC -!- DOMAIN: The Elongin BC complex binding domain is also known as BC-box
CC with the consensus [APST]-L-x(3)-C-x(3)-[AILV]. {ECO:0000250}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-23 is the initiator.
CC {ECO:0000305}.
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DR EMBL; BC087037; AAH87037.1; -; mRNA.
DR RefSeq; NP_001009710.1; NM_001009710.1.
DR AlphaFoldDB; Q5M9H1; -.
DR SMR; Q5M9H1; -.
DR BioGRID; 263543; 2.
DR CORUM; Q5M9H1; -.
DR STRING; 10116.ENSRNOP00000018506; -.
DR iPTMnet; Q5M9H1; -.
DR PhosphoSitePlus; Q5M9H1; -.
DR PaxDb; Q5M9H1; -.
DR PRIDE; Q5M9H1; -.
DR Ensembl; ENSRNOT00000018506; ENSRNOP00000018506; ENSRNOG00000013642.
DR GeneID; 362566; -.
DR KEGG; rno:362566; -.
DR UCSC; RGD:1311221; rat.
DR CTD; 10489; -.
DR RGD; 1311221; Lrrc41.
DR eggNOG; ENOG502R5T0; Eukaryota.
DR GeneTree; ENSGT00390000015908; -.
DR HOGENOM; CLU_021836_0_0_1; -.
DR InParanoid; Q5M9H1; -.
DR OMA; PECRFRV; -.
DR OrthoDB; 322569at2759; -.
DR PhylomeDB; Q5M9H1; -.
DR TreeFam; TF335481; -.
DR Reactome; R-RNO-8951664; Neddylation.
DR Reactome; R-RNO-9706019; RHOBTB3 ATPase cycle.
DR Reactome; R-RNO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q5M9H1; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000013642; Expressed in ovary and 19 other tissues.
DR Genevisible; Q5M9H1; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR026137; Leu_rpt_41.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR15354; PTHR15354; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..808
FT /note="Leucine-rich repeat-containing protein 41"
FT /id="PRO_0000292659"
FT REPEAT 483..503
FT /note="LRR 1"
FT REPEAT 514..526
FT /note="LRR 2"
FT REPEAT 527..551
FT /note="LRR 3"
FT REPEAT 609..631
FT /note="LRR 4"
FT REPEAT 632..655
FT /note="LRR 5"
FT REPEAT 697..724
FT /note="LRR 6"
FT REPEAT 727..748
FT /note="LRR 7"
FT REGION 45..54
FT /note="Interaction with Elongin BC complex"
FT /evidence="ECO:0000250"
FT REGION 269..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 155
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q15345"
FT MOD_RES 276
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q15345"
FT MOD_RES 326
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q15345"
FT MOD_RES 327
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q15345"
FT MOD_RES 369
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q15345"
SQ SEQUENCE 808 AA; 88508 MW; B2634B486F4207DD CRC64;
MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP SAPPALFELC GRAVSAHMGV
LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ AIWRRLWDEL MKTRPSSLES
VTCWRAKFME AFFSHVLRGT IDVSSDKRLC DQRFSPLLHS SRHVRQLTIC NMLQGATELV
AEPNRRVLET LASSLHTLKF RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES
ALFILILTMS AGFWQPGPGS LPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA
LMATRRKSEV KQVPRALPTS RVTRRSTQES LTIGGTDSKR ELYPPATSYE ASGTKQPSSA
PTAASSSTSS KRAPASSVSQ PKPLKRFKRA TGKKGPRTRQ GSGAESEDLY DFVFIVAGEK
EDGEEMEIGE VACGALDGSD PSCLGLPALE ASQRFRSIST LELFTVPLST EAALTLCHLL
SSWVSLESLT LSYNGLGSNI FRLLDSLRVL SGQAGCRLRA LHLSDLFSPL PILELTRAIV
RALPLLRVLS IRVDHPSQRD NPAVPENAGP PGHIIGDEEI PENCLEQLEM GFPRGAQPAP
LLCSVLKASG SLQQLSLDSA TFASPQDFGL VLQTLKEYNL SLKRLSFHDM NLADCQSEVL
FLLKNLTLQE ITFSFCRLFE KRPAQFLPEM VAAMKGNSTL KGLRLPGNRL GNAGLLALAD
VFSEDSSSSL CQLDISSNCI KPDGLLEFAK RLERWGRGAF GHLRLFQNWL DQDAVTAREA
IRRLRATCHV VSDSWDSTQA FADYVSTM
