LRC42_DANRE
ID LRC42_DANRE Reviewed; 407 AA.
AC Q6P5J6; Q7ZWF1;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Leucine-rich repeat-containing protein 42;
GN Name=lrrc42; ORFNames=si:dkey-181m9.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the LRRC42 family. {ECO:0000305}.
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DR EMBL; BX248497; CAQ14065.1; -; Genomic_DNA.
DR EMBL; BC049443; AAH49443.1; -; mRNA.
DR EMBL; BC062861; AAH62861.1; -; mRNA.
DR RefSeq; NP_956041.2; NM_199747.2.
DR AlphaFoldDB; Q6P5J6; -.
DR STRING; 7955.ENSDARP00000045055; -.
DR PaxDb; Q6P5J6; -.
DR Ensembl; ENSDART00000045056; ENSDARP00000045055; ENSDARG00000030591.
DR GeneID; 326793; -.
DR KEGG; dre:326793; -.
DR CTD; 115353; -.
DR ZFIN; ZDB-GENE-030131-4992; lrrc42.
DR eggNOG; ENOG502QQJZ; Eukaryota.
DR GeneTree; ENSGT00390000002727; -.
DR HOGENOM; CLU_053705_0_0_1; -.
DR InParanoid; Q6P5J6; -.
DR OMA; QMPKQKK; -.
DR OrthoDB; 1204825at2759; -.
DR PhylomeDB; Q6P5J6; -.
DR TreeFam; TF331102; -.
DR PRO; PR:Q6P5J6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 2.
DR Bgee; ENSDARG00000030591; Expressed in ovary and 29 other tissues.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR039631; LRRC42.
DR PANTHER; PTHR31994; PTHR31994; 1.
DR PROSITE; PS51450; LRR; 3.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..407
FT /note="Leucine-rich repeat-containing protein 42"
FT /id="PRO_0000360041"
FT REPEAT 138..159
FT /note="LRR 1"
FT REPEAT 163..184
FT /note="LRR 2"
FT REPEAT 191..211
FT /note="LRR 3"
FT REPEAT 223..243
FT /note="LRR 4"
FT REPEAT 247..268
FT /note="LRR 5"
FT REGION 360..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 53
FT /note="S -> T (in Ref. 1; AAH49443)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="L -> I (in Ref. 1; AAH49443)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="M -> T (in Ref. 1; AAH49443)"
FT /evidence="ECO:0000305"
FT CONFLICT 270
FT /note="M -> MK (in Ref. 1; AAH49443)"
FT /evidence="ECO:0000305"
FT CONFLICT 387
FT /note="A -> T (in Ref. 1; AAH49443)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 407 AA; 46403 MW; 60B2888F16A1C225 CRC64;
MYLGEDCGAV YVRENGELRC VSAVKTVDPP PQNRLFTRDF TFQLCIDTLP SASRAERRDH
FIFTYNKQGS LRYSVKTLFD ISLQFIADHV EHVDSLVGFP EQMADKLFSA AEERGKFAEL
RTASRALQLF CEAYGELVLK SLCLRNRYLL ISERLEEIRQ FQSLECLDLY GCRLGDNHEL
FKYITSEALS SLVKLFMGAN CLSDAGLQRL TAPVRVMKKG LENLQLLDLS ENHITEKGLR
YLTCFKTLQK LDLSGTKVMM DVSLKGFFRM MGMALSETPL MDFTHTACKT EGWAEQVINQ
WEITAAEVPK KDPKPRTNAL RFYGREKFVR EMLNSWSETS DATNKDKAVP IHFCKVDDCV
QSSPSGETHS THKSRKRRLS TEEEQSAAPV AKRLPLSVED LHLLNSY
