LRC42_HUMAN
ID LRC42_HUMAN Reviewed; 428 AA.
AC Q9Y546; D3DQ46; Q8N2Q8;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Leucine-rich repeat-containing protein 42;
GN Name=LRRC42;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
CC -!- SIMILARITY: Belongs to the LRRC42 family. {ECO:0000305}.
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DR EMBL; AK075201; BAC11466.1; ALT_TERM; mRNA.
DR EMBL; AK074521; BAC11038.1; -; mRNA.
DR EMBL; CH471059; EAX06713.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX06714.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX06715.1; -; Genomic_DNA.
DR EMBL; BC013101; AAH13101.1; -; mRNA.
DR CCDS; CCDS585.1; -.
DR RefSeq; NP_001243338.1; NM_001256409.1.
DR RefSeq; NP_443172.1; NM_052940.4.
DR RefSeq; XP_006710390.1; XM_006710327.3.
DR RefSeq; XP_006710391.1; XM_006710328.3.
DR AlphaFoldDB; Q9Y546; -.
DR BioGRID; 125429; 19.
DR IntAct; Q9Y546; 7.
DR MINT; Q9Y546; -.
DR STRING; 9606.ENSP00000360421; -.
DR iPTMnet; Q9Y546; -.
DR PhosphoSitePlus; Q9Y546; -.
DR BioMuta; LRRC42; -.
DR DMDM; 74762064; -.
DR EPD; Q9Y546; -.
DR jPOST; Q9Y546; -.
DR MassIVE; Q9Y546; -.
DR MaxQB; Q9Y546; -.
DR PaxDb; Q9Y546; -.
DR PeptideAtlas; Q9Y546; -.
DR PRIDE; Q9Y546; -.
DR ProteomicsDB; 86287; -.
DR Antibodypedia; 46891; 125 antibodies from 22 providers.
DR DNASU; 115353; -.
DR Ensembl; ENST00000319223.8; ENSP00000318185.4; ENSG00000116212.15.
DR Ensembl; ENST00000371370.8; ENSP00000360421.3; ENSG00000116212.15.
DR GeneID; 115353; -.
DR KEGG; hsa:115353; -.
DR MANE-Select; ENST00000371370.8; ENSP00000360421.3; NM_001256409.2; NP_001243338.1.
DR UCSC; uc001cwj.3; human.
DR CTD; 115353; -.
DR DisGeNET; 115353; -.
DR GeneCards; LRRC42; -.
DR HGNC; HGNC:28792; LRRC42.
DR HPA; ENSG00000116212; Low tissue specificity.
DR neXtProt; NX_Q9Y546; -.
DR OpenTargets; ENSG00000116212; -.
DR PharmGKB; PA142671530; -.
DR VEuPathDB; HostDB:ENSG00000116212; -.
DR eggNOG; ENOG502QQJZ; Eukaryota.
DR GeneTree; ENSGT00390000002727; -.
DR InParanoid; Q9Y546; -.
DR OMA; QMPKQKK; -.
DR OrthoDB; 1204825at2759; -.
DR PhylomeDB; Q9Y546; -.
DR TreeFam; TF331102; -.
DR PathwayCommons; Q9Y546; -.
DR SignaLink; Q9Y546; -.
DR BioGRID-ORCS; 115353; 13 hits in 1076 CRISPR screens.
DR GenomeRNAi; 115353; -.
DR Pharos; Q9Y546; Tdark.
DR PRO; PR:Q9Y546; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9Y546; protein.
DR Bgee; ENSG00000116212; Expressed in oocyte and 140 other tissues.
DR ExpressionAtlas; Q9Y546; baseline and differential.
DR Genevisible; Q9Y546; HS.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR039631; LRRC42.
DR PANTHER; PTHR31994; PTHR31994; 1.
DR Pfam; PF13516; LRR_6; 3.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..428
FT /note="Leucine-rich repeat-containing protein 42"
FT /id="PRO_0000223622"
FT REPEAT 149..170
FT /note="LRR 1"
FT REPEAT 174..195
FT /note="LRR 2"
FT REPEAT 202..222
FT /note="LRR 3"
FT REPEAT 234..255
FT /note="LRR 4"
FT REPEAT 259..280
FT /note="LRR 5"
FT REGION 379..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 406
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R2U7"
FT MOD_RES 407
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17525332"
FT CONFLICT 362
FT /note="K -> R (in Ref. 1; BAC11038)"
FT /evidence="ECO:0000305"
FT CONFLICT 395
FT /note="P -> S (in Ref. 1; BAC11038)"
FT /evidence="ECO:0000305"
FT CONFLICT 413..428
FT /note="KYVCLAVEDWDLLNSY -> IFLLLWCGRGMLWKYVIISNVYFQYIVIFSNK
FT HFCCP (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 428 AA; 48571 MW; EC22D6E407E36B87 CRC64;
MSYYLSSENH LDPGPIYMRE NGQLHMVNLA LDGVRSSLQK PRPFRLFPKG FSVELCMNRE
DDTARKEKTD HFIFTYTREG NLRYSAKSLF SLVLGFISDN VDHIDSLIGF PEQIAEKLFS
AAEARQKFTE PGAGLRALQK FTEAYGSLVL CSLCLRNRYL VISEKLEEIK SFRELTCLDL
SCCKLGDEHE LLEHLTNEAL SSVTQLHLKD NCLSDAGVRK MTAPVRVMKR GLENLTLLDL
SCNPEITDAG IGYLFSFRKL NCLDISGTGL KDIKTVKHKL QTHIGLVHSK VPLKEFDHSN
CKTEGWADQI VLQWERVTAE AVKPRETSEP RAAAQRFYGK RSRAEAPLKC PLADTHMNSS
EKLQFYKEKA PDCHGPVLKH EAISSQESKK SKKRPFEESE TEQNNSSQPS KQKYVCLAVE
DWDLLNSY
