LRC42_MOUSE
ID LRC42_MOUSE Reviewed; 421 AA.
AC Q8R2U7; Q3TE62; Q9CTP9;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Leucine-rich repeat-containing protein 42;
GN Name=Lrrc42;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Retina, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Eye, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the LRRC42 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE41386.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK020847; BAB32227.3; -; mRNA.
DR EMBL; AK169814; BAE41386.1; ALT_INIT; mRNA.
DR EMBL; BC027203; AAH27203.1; -; mRNA.
DR EMBL; BC031894; AAH31894.1; -; mRNA.
DR CCDS; CCDS18434.1; -.
DR RefSeq; NP_084261.1; NM_029985.2.
DR AlphaFoldDB; Q8R2U7; -.
DR BioGRID; 218940; 1.
DR IntAct; Q8R2U7; 1.
DR STRING; 10090.ENSMUSP00000030360; -.
DR iPTMnet; Q8R2U7; -.
DR PhosphoSitePlus; Q8R2U7; -.
DR EPD; Q8R2U7; -.
DR MaxQB; Q8R2U7; -.
DR PaxDb; Q8R2U7; -.
DR PeptideAtlas; Q8R2U7; -.
DR PRIDE; Q8R2U7; -.
DR ProteomicsDB; 287269; -.
DR Antibodypedia; 46891; 125 antibodies from 22 providers.
DR DNASU; 77809; -.
DR Ensembl; ENSMUST00000030360; ENSMUSP00000030360; ENSMUSG00000028617.
DR GeneID; 77809; -.
DR KEGG; mmu:77809; -.
DR UCSC; uc008tzm.1; mouse.
DR CTD; 115353; -.
DR MGI; MGI:1925059; Lrrc42.
DR VEuPathDB; HostDB:ENSMUSG00000028617; -.
DR eggNOG; ENOG502QQJZ; Eukaryota.
DR GeneTree; ENSGT00390000002727; -.
DR HOGENOM; CLU_053705_0_0_1; -.
DR InParanoid; Q8R2U7; -.
DR OMA; QMPKQKK; -.
DR OrthoDB; 1204825at2759; -.
DR PhylomeDB; Q8R2U7; -.
DR TreeFam; TF331102; -.
DR BioGRID-ORCS; 77809; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Lrrc42; mouse.
DR PRO; PR:Q8R2U7; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8R2U7; protein.
DR Bgee; ENSMUSG00000028617; Expressed in ear vesicle and 261 other tissues.
DR ExpressionAtlas; Q8R2U7; baseline and differential.
DR Genevisible; Q8R2U7; MM.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR039631; LRRC42.
DR PANTHER; PTHR31994; PTHR31994; 1.
DR Pfam; PF13516; LRR_6; 3.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..421
FT /note="Leucine-rich repeat-containing protein 42"
FT /id="PRO_0000223471"
FT REPEAT 149..170
FT /note="LRR 1"
FT REPEAT 174..195
FT /note="LRR 2"
FT REPEAT 202..222
FT /note="LRR 3"
FT REPEAT 234..255
FT /note="LRR 4"
FT REPEAT 259..280
FT /note="LRR 5"
FT REGION 376..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 399
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 421 AA; 47949 MW; 154A267B78C732BD CRC64;
MAYYLNSEAH LDPGPIYVRE NGQLHMVNLA LDGVKNSLQK PRPFRLFPKG FSVELCMNRE
DDTAQKEKTD HFIFTYTREG NLRYSAKSLF SLVLGFISDN VDHIDSLIGF PEQIAEKLFS
AAEARQKFTE PGAGLRALQK FTEAYGSLVL CSLCLRNRYL VVAEKLEEIK SFRELTRLDL
SCCWLGDEHE LLEHLTNEAL SSVTQLHLKD NCLSDAGIRK MTAPVRVMKR GLENLALLDL
SCNPEITDAG IGYLFSFRKL NCLDISGTGL KDIKAVKDKL RANIGLVHSK VPLKEFDHSN
CKTEGWADQI VLQWERVSVE AVRQRKDVEP RKAAQYFYQN RARTEVTRKC PLAETHMNSS
GKLQFYREEA PDCHEPLLSQ ESKKSKKRAF KESEQEQSSP QSAKQKCVCL AVEDWDLLNS
Y
