ID   LRC42_RAT               Reviewed;         421 AA.
AC   Q4KM95;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Leucine-rich repeat-containing protein 42;
GN   Name=Lrrc42;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- SIMILARITY: Belongs to the LRRC42 family. {ECO:0000305}.
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DR   EMBL; BC098685; AAH98685.1; -; mRNA.
DR   RefSeq; NP_001020824.1; NM_001025653.1.
DR   RefSeq; XP_006238565.1; XM_006238503.3.
DR   AlphaFoldDB; Q4KM95; -.
DR   STRING; 10116.ENSRNOP00000013575; -.
DR   PaxDb; Q4KM95; -.
DR   PRIDE; Q4KM95; -.
DR   Ensembl; ENSRNOT00000013575; ENSRNOP00000013575; ENSRNOG00000009983.
DR   GeneID; 298309; -.
DR   KEGG; rno:298309; -.
DR   CTD; 115353; -.
DR   RGD; 1308919; Lrrc42.
DR   eggNOG; ENOG502QQJZ; Eukaryota.
DR   GeneTree; ENSGT00390000002727; -.
DR   HOGENOM; CLU_053705_0_0_1; -.
DR   InParanoid; Q4KM95; -.
DR   OMA; QMPKQKK; -.
DR   OrthoDB; 1204825at2759; -.
DR   PhylomeDB; Q4KM95; -.
DR   TreeFam; TF331102; -.
DR   PRO; PR:Q4KM95; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000009983; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q4KM95; RN.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR039631; LRRC42.
DR   PANTHER; PTHR31994; PTHR31994; 1.
DR   Pfam; PF13516; LRR_6; 3.
PE   1: Evidence at protein level;
KW   Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..421
FT                   /note="Leucine-rich repeat-containing protein 42"
FT                   /id="PRO_0000223472"
FT   REPEAT          149..170
FT                   /note="LRR 1"
FT   REPEAT          174..195
FT                   /note="LRR 2"
FT   REPEAT          202..222
FT                   /note="LRR 3"
FT   REPEAT          234..255
FT                   /note="LRR 4"
FT   REPEAT          259..280
FT                   /note="LRR 5"
FT   REGION          374..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..394
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         399
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R2U7"
SQ   SEQUENCE   421 AA;  47914 MW;  6DE81AE13A68E228 CRC64;
     MAYYLNSEAH LDPGPIYVRE NGQLHMVSLA LDGVKNSLQK PRPFRLFPKG FSVELCMNRE
     DDTAQKEKTD HFIFTYTREG NLRYSAKSLF SLVLGFISDN VDHIDSLIGF PEQIAEKLFS
     AAEARQKFTE PGAGLRALQK FTEAYGSLVL CSLCLRNRYL VVAEKLEEIK SFRELTRLDL
     SCCWLGDEHE LLEHLTNEAL SSVTQLHLKD NCLSDAGIRK MTAPVRVLKR GLENLTLLDL
     SCNPEITDAG IGYLFSFRKL NCLDISGTGL KDIKAVKDKL RTHIGLVHSK VPLKEFDHSN
     CKTEGWADQI VLQWERVSVE AVRQRKDPEP RKAAQYFYQK RALTEASRKC PLAETHMNSS
     GKLQFYREKA PDCHEPLLSQ ESKKSKKRAF EESEQEQSSP QSAKQKCVCL AVEDWDLLNS
     Y