LRC43_MOUSE
ID LRC43_MOUSE Reviewed; 667 AA.
AC Q3V0L5; Q3TIS6; Q3TJS5;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Leucine-rich repeat-containing protein 43;
GN Name=Lrrc43; Synonyms=Gm1061;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Placenta, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3V0L5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3V0L5-2; Sequence=VSP_029638;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE39420.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK133051; BAE21489.1; -; mRNA.
DR EMBL; AK167318; BAE39420.1; ALT_INIT; mRNA.
DR EMBL; AK167729; BAE39770.1; -; mRNA.
DR CCDS; CCDS19664.1; -. [Q3V0L5-1]
DR CCDS; CCDS71662.1; -. [Q3V0L5-2]
DR RefSeq; NP_001028633.1; NM_001033461.3. [Q3V0L5-1]
DR RefSeq; NP_001276750.1; NM_001289821.1. [Q3V0L5-2]
DR RefSeq; NP_001276751.1; NM_001289822.1.
DR AlphaFoldDB; Q3V0L5; -.
DR SMR; Q3V0L5; -.
DR STRING; 10090.ENSMUSP00000091885; -.
DR iPTMnet; Q3V0L5; -.
DR PhosphoSitePlus; Q3V0L5; -.
DR PaxDb; Q3V0L5; -.
DR PRIDE; Q3V0L5; -.
DR ProteomicsDB; 290154; -. [Q3V0L5-1]
DR ProteomicsDB; 290155; -. [Q3V0L5-2]
DR Antibodypedia; 52948; 26 antibodies from 14 providers.
DR Ensembl; ENSMUST00000094327; ENSMUSP00000091885; ENSMUSG00000063409. [Q3V0L5-1]
DR Ensembl; ENSMUST00000121444; ENSMUSP00000113933; ENSMUSG00000063409. [Q3V0L5-2]
DR GeneID; 381741; -.
DR KEGG; mmu:381741; -.
DR UCSC; uc008znu.2; mouse. [Q3V0L5-1]
DR UCSC; uc008znv.2; mouse. [Q3V0L5-2]
DR CTD; 254050; -.
DR MGI; MGI:2685907; Lrrc43.
DR VEuPathDB; HostDB:ENSMUSG00000063409; -.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00390000008994; -.
DR HOGENOM; CLU_028116_0_0_1; -.
DR InParanoid; Q3V0L5; -.
DR OMA; STAHKPW; -.
DR OrthoDB; 428855at2759; -.
DR PhylomeDB; Q3V0L5; -.
DR TreeFam; TF330806; -.
DR BioGRID-ORCS; 381741; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Lrrc43; mouse.
DR PRO; PR:Q3V0L5; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q3V0L5; protein.
DR Bgee; ENSMUSG00000063409; Expressed in testis and 16 other tissues.
DR ExpressionAtlas; Q3V0L5; baseline and differential.
DR GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IBA:GO_Central.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..667
FT /note="Leucine-rich repeat-containing protein 43"
FT /id="PRO_0000311910"
FT REPEAT 148..169
FT /note="LRR 1"
FT REPEAT 170..191
FT /note="LRR 2"
FT REPEAT 194..213
FT /note="LRR 3"
FT REPEAT 221..242
FT /note="LRR 4"
FT DOMAIN 256..294
FT /note="LRRCT"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 515..521
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029638"
SQ SEQUENCE 667 AA; 74942 MW; 12D64594105C6FD4 CRC64;
METSESSTSD YRQTEGEGEG VPGTLSTAVC EHLRKLCLRE FPCGIGSWNK SRFLPQKCRV
WRELVPKEEE TLVPEEETVE ALLGLVRSNH SPWAMLKDAS AEDRFLRELA IQNPLMIKDT
FFYSYFRSLR VVNKGVSLVD KDLLKFLKLE ELVLSANKIE EIDANNLPPT LKVLELYGNL
IASMECLCSA PPPRLQHLGL GHNKLLGPLE SLYVTSHNWP QLVSLDLGFN NLTDLQNMIL
GLSTLRHLRL LVLQGNPLSL VPYYRGFTID SLAHLCVLDD ITVSPNEKHQ FRGLNIHGDL
LAREAQFVVT IGNVRGVLDS SILDPEPGPD GPFISYSYYV TYDFVEDEDM ERNVSGLVEA
THHDSVLDEI DKHFSGTDEE DQQEDPLDGR HRHRGRQRFH PGSTEEMSKE LSEFIAKEMS
QMAEGSVESG ITEVDWSETS ISIHSAPLPQ SIDSSEELAK LRPKIDIQLC PSPGTVLFNT
VHKPWSDVIP CTYEMKHTLK ELIRVKAFLL AGTTVSIVEE KILSWPVVPT PVESPLPAKK
GKDNNKKKEP AKDKVHKKKK EPPRELRQDP PVLTVLGSGL VYLEPLLAGE AVVSTVCNFG
VVRTLETDRL THARDSKKVK KSLKKDRSKT VPPTMESGYQ PEPLSVEVQI QLHQYRSVEE
AFLSLID
