ID   LRC45_CHICK             Reviewed;         670 AA.
AC   Q5ZI11;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Leucine-rich repeat-containing protein 45;
GN   Name=LRRC45; ORFNames=RCJMB04_31i7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the proteinaceous fiber-like linker between two
CC       centrioles, required for centrosome cohesion.
CC       {ECO:0000250|UniProtKB:Q96CN5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q96CN5}. Note=Localizes to
CC       the proteinaceous linker between the proximal ends of the centrioles.
CC       {ECO:0000250|UniProtKB:Q96CN5}.
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DR   EMBL; AJ720973; CAG32632.1; -; mRNA.
DR   RefSeq; NP_001073224.1; NM_001079756.2.
DR   AlphaFoldDB; Q5ZI11; -.
DR   SMR; Q5ZI11; -.
DR   STRING; 9031.ENSGALP00000004528; -.
DR   PaxDb; Q5ZI11; -.
DR   PRIDE; Q5ZI11; -.
DR   GeneID; 770573; -.
DR   KEGG; gga:770573; -.
DR   CTD; 201255; -.
DR   VEuPathDB; HostDB:geneid_770573; -.
DR   eggNOG; KOG4308; Eukaryota.
DR   InParanoid; Q5ZI11; -.
DR   OrthoDB; 1456539at2759; -.
DR   PhylomeDB; Q5ZI11; -.
DR   PRO; PR:Q5ZI11; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 3.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Leucine-rich repeat;
KW   Reference proteome; Repeat.
FT   CHAIN           1..670
FT                   /note="Leucine-rich repeat-containing protein 45"
FT                   /id="PRO_0000223925"
FT   REPEAT          87..108
FT                   /note="LRR 1"
FT   REPEAT          115..136
FT                   /note="LRR 2"
FT   REPEAT          145..166
FT                   /note="LRR 3"
FT   REPEAT          173..194
FT                   /note="LRR 4"
FT   REPEAT          201..223
FT                   /note="LRR 5"
FT   COILED          234..645
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   670 AA;  76068 MW;  A885BD469B0CAE7B CRC64;
     MEEFRRAYAK LCAAPQEAVL RRLRERGEAP GRARLDLAEQ SLSLETCGAL GRLLPGAAHF
     AEVALGDCGL SEDGVKLLLH GLCSNSTVKS LDLKGNNLRT TGAEALGKLL RQNKSIRSLI
     LEWNSLGVWE EGFSFFCQGL GANNFLQRLD LRNNQINHHG AGELAMALKR NASLQELDLR
     WNNIGLLGGR ALLNCLQSNK TLKKLELAGN NVPSDILKAV EQAMDHNRDR QTILSETQNR
     TSVLSKEILN LKDEKTKQFL DLMDTIDKQR EEIARSGRIS AGRVSQLQEA LNEQHSIMNS
     LKAKLQMTEA ALALSEQKVH NLGELLSATK QEQASMAERH FAELQQQKQE GADREGKLFR
     DLSASNEKNL FLRNQVDELE KKCKVQQDQI FQLKQDLTNT TAELKLRAVQ AEERLEMEKR
     RFKQSLEDME SLRLKEVDHL TQHMEASERS MQDRVQRLEA IRIALEEELS QVKAAALTER
     GHAEEELIKV RNQARLEEQQ RVEHLEEKLR LMTEARDEAQ NCCLKQKQMV GEAQVKANQL
     NLHADGLRRR IEELQQDLNS KEQEKVTEVN KVKVELQEQI GHLQAERTAQ EGLREKIAAL
     ERQLKVLSSN HREALLDKEG EISMLMEKLR MKEADISRMK EEEAQRASIL QNAIMAYVQG
     SSLGTHSLRK