LRC46_HUMAN
ID LRC46_HUMAN Reviewed; 321 AA.
AC Q96FV0; A8K9Q0;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Leucine-rich repeat-containing protein 46;
GN Name=LRRC46;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK292765; BAF85454.1; -; mRNA.
DR EMBL; AK315665; BAG38031.1; -; mRNA.
DR EMBL; CH471109; EAW94793.1; -; Genomic_DNA.
DR EMBL; BC010412; AAH10412.1; -; mRNA.
DR CCDS; CCDS11518.1; -.
DR RefSeq; NP_219481.1; NM_033413.3.
DR AlphaFoldDB; Q96FV0; -.
DR SMR; Q96FV0; -.
DR BioGRID; 124725; 25.
DR IntAct; Q96FV0; 22.
DR STRING; 9606.ENSP00000269025; -.
DR iPTMnet; Q96FV0; -.
DR PhosphoSitePlus; Q96FV0; -.
DR BioMuta; LRRC46; -.
DR DMDM; 74760826; -.
DR jPOST; Q96FV0; -.
DR MassIVE; Q96FV0; -.
DR PaxDb; Q96FV0; -.
DR PeptideAtlas; Q96FV0; -.
DR PRIDE; Q96FV0; -.
DR ProteomicsDB; 76558; -.
DR Antibodypedia; 17777; 83 antibodies from 15 providers.
DR DNASU; 90506; -.
DR Ensembl; ENST00000269025.9; ENSP00000269025.4; ENSG00000141294.10.
DR GeneID; 90506; -.
DR KEGG; hsa:90506; -.
DR MANE-Select; ENST00000269025.9; ENSP00000269025.4; NM_033413.4; NP_219481.1.
DR UCSC; uc002ima.3; human.
DR CTD; 90506; -.
DR DisGeNET; 90506; -.
DR GeneCards; LRRC46; -.
DR HGNC; HGNC:25047; LRRC46.
DR HPA; ENSG00000141294; Group enriched (fallopian tube, testis).
DR neXtProt; NX_Q96FV0; -.
DR OpenTargets; ENSG00000141294; -.
DR PharmGKB; PA142671506; -.
DR VEuPathDB; HostDB:ENSG00000141294; -.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00940000161315; -.
DR HOGENOM; CLU_075587_0_0_1; -.
DR InParanoid; Q96FV0; -.
DR OMA; VSERWAS; -.
DR OrthoDB; 1445923at2759; -.
DR PhylomeDB; Q96FV0; -.
DR TreeFam; TF324815; -.
DR PathwayCommons; Q96FV0; -.
DR SignaLink; Q96FV0; -.
DR BioGRID-ORCS; 90506; 19 hits in 1077 CRISPR screens.
DR GenomeRNAi; 90506; -.
DR Pharos; Q96FV0; Tdark.
DR PRO; PR:Q96FV0; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q96FV0; protein.
DR Bgee; ENSG00000141294; Expressed in right uterine tube and 137 other tissues.
DR ExpressionAtlas; Q96FV0; baseline and differential.
DR Genevisible; Q96FV0; HS.
DR GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IBA:GO_Central.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 2.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW Coiled coil; Leucine-rich repeat; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..321
FT /note="Leucine-rich repeat-containing protein 46"
FT /id="PRO_0000223919"
FT REPEAT 45..66
FT /note="LRR 1"
FT REPEAT 67..88
FT /note="LRR 2"
FT REPEAT 89..110
FT /note="LRR 3"
FT REPEAT 111..132
FT /note="LRR 4"
FT DOMAIN 142..184
FT /note="LRRCT"
FT REGION 235..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 201..221
FT /evidence="ECO:0000255"
FT COMPBIAS 249..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 175
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9DAP0"
FT MOD_RES 182
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9DAP0"
SQ SEQUENCE 321 AA; 35340 MW; 04788DD11D410BB5 CRC64;
MSGGKSAQGP EEGGVCITEA LITKRNLTFP EDGELSEKMF HTLDELQTVR LDREGITTIR
NLEGLQNLHS LYLQGNKIQQ IENLACIPSL RFLSLAGNQI RQVENLLDLP CLQFLDLSEN
LIETLKLDEF PQSLLILNLS GNSCTNQDGY RELVTEALPL LLDLDGQPVV ERWISDEEDE
ASSDEEFPEL SGPFCSERGF LKELEQELSR HREHRQQTAL TEHLLRMEMQ PTLTDLPLLP
GVPMAGDSSP SATPAQGEET VPEAVSSPQA SSPTKKPCSL IPRGHQSSFW GRKGARAATA
PKASVAEAPS TTKTTAKRSK K
