LRC46_MOUSE
ID LRC46_MOUSE Reviewed; 323 AA.
AC Q9DAP0; Q8R1Z3;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2006, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Leucine-rich repeat-containing protein 46;
GN Name=Lrrc46;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-178; SER-179; SER-185 AND
RP SER-186, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK005668; BAB24177.1; -; mRNA.
DR EMBL; AK158517; BAE34541.1; -; mRNA.
DR EMBL; BC022723; AAH22723.1; -; mRNA.
DR CCDS; CCDS25311.1; -.
DR RefSeq; NP_081302.2; NM_027026.2.
DR AlphaFoldDB; Q9DAP0; -.
DR SMR; Q9DAP0; -.
DR STRING; 10090.ENSMUSP00000021251; -.
DR iPTMnet; Q9DAP0; -.
DR PhosphoSitePlus; Q9DAP0; -.
DR PaxDb; Q9DAP0; -.
DR PRIDE; Q9DAP0; -.
DR ProteomicsDB; 290156; -.
DR Antibodypedia; 17777; 83 antibodies from 15 providers.
DR DNASU; 69297; -.
DR Ensembl; ENSMUST00000021251; ENSMUSP00000021251; ENSMUSG00000020878.
DR GeneID; 69297; -.
DR KEGG; mmu:69297; -.
DR UCSC; uc007ldl.1; mouse.
DR CTD; 90506; -.
DR MGI; MGI:1916547; Lrrc46.
DR VEuPathDB; HostDB:ENSMUSG00000020878; -.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00940000161315; -.
DR HOGENOM; CLU_075587_0_0_1; -.
DR InParanoid; Q9DAP0; -.
DR OMA; VSERWAS; -.
DR OrthoDB; 1445923at2759; -.
DR PhylomeDB; Q9DAP0; -.
DR TreeFam; TF324815; -.
DR BioGRID-ORCS; 69297; 5 hits in 74 CRISPR screens.
DR PRO; PR:Q9DAP0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9DAP0; protein.
DR Bgee; ENSMUSG00000020878; Expressed in seminiferous tubule of testis and 72 other tissues.
DR Genevisible; Q9DAP0; MM.
DR GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IBA:GO_Central.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PROSITE; PS51450; LRR; 5.
PE 1: Evidence at protein level;
KW Coiled coil; Leucine-rich repeat; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..323
FT /note="Leucine-rich repeat-containing protein 46"
FT /id="PRO_0000223921"
FT REPEAT 49..70
FT /note="LRR 1"
FT REPEAT 71..92
FT /note="LRR 2"
FT REPEAT 93..114
FT /note="LRR 3"
FT REPEAT 115..135
FT /note="LRR 4"
FT DOMAIN 146..188
FT /note="LRRCT"
FT REGION 249..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 203..228
FT /evidence="ECO:0000255"
FT COMPBIAS 253..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 178
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 179
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 185
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 186
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 303
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXZ2"
FT CONFLICT 234
FT /note="T -> K (in Ref. 1; BAB24177)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 323 AA; 36048 MW; 1E7408543E4A53CF CRC64;
MPGDEQEAKK AAQRTEEGVH ITEALITKRN LTFPGDEDLS EKMFHTLGEL ETVRLDGEGI
TCIGNLEKLR NIHSLYLQSN KIQRIENLAC ITSLRFLSLA RNQIRHVENL LDLQYLQFLD
LSENLIETLK LDELPESLLI LNLCGNPCTN QEGYRKMVIG ALPLLLDLDK QPILERWTSD
EEDKSSDDDD EFPELNGPFC AERGFFKDLE QELHQHQERR QQAALTEHLS RMETQPVLTD
LPLLPAVPMA GDCSSTATDQ PGKESAPKAT SSTQTASTTK KQVSKNQKSS VQARKGALAA
TTSKTSQAAT PSMTKMTNKK STK
