ID   LRC46_RAT               Reviewed;         323 AA.
AC   Q6AXZ2;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Leucine-rich repeat-containing protein 46;
GN   Name=Lrrc46;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-178; SER-179 AND SER-303, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
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DR   EMBL; BC079258; AAH79258.1; -; mRNA.
DR   RefSeq; NP_001004201.1; NM_001004201.1.
DR   AlphaFoldDB; Q6AXZ2; -.
DR   SMR; Q6AXZ2; -.
DR   STRING; 10116.ENSRNOP00000013542; -.
DR   iPTMnet; Q6AXZ2; -.
DR   PhosphoSitePlus; Q6AXZ2; -.
DR   PaxDb; Q6AXZ2; -.
DR   PRIDE; Q6AXZ2; -.
DR   GeneID; 287653; -.
DR   KEGG; rno:287653; -.
DR   UCSC; RGD:1303311; rat.
DR   CTD; 90506; -.
DR   RGD; 1303311; Lrrc46.
DR   eggNOG; KOG0531; Eukaryota.
DR   InParanoid; Q6AXZ2; -.
DR   OrthoDB; 1445923at2759; -.
DR   PhylomeDB; Q6AXZ2; -.
DR   PRO; PR:Q6AXZ2; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR   GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0035307; P:positive regulation of protein dephosphorylation; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PROSITE; PS51450; LRR; 5.
PE   1: Evidence at protein level;
KW   Coiled coil; Leucine-rich repeat; Phosphoprotein; Reference proteome;
KW   Repeat.
FT   CHAIN           1..323
FT                   /note="Leucine-rich repeat-containing protein 46"
FT                   /id="PRO_0000223922"
FT   REPEAT          49..70
FT                   /note="LRR 1"
FT   REPEAT          71..92
FT                   /note="LRR 2"
FT   REPEAT          93..114
FT                   /note="LRR 3"
FT   REPEAT          115..135
FT                   /note="LRR 4"
FT   DOMAIN          146..188
FT                   /note="LRRCT"
FT   REGION          252..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          203..228
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        267..289
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..323
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         178
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         179
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         185
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DAP0"
FT   MOD_RES         186
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DAP0"
FT   MOD_RES         303
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   323 AA;  36003 MW;  DB552AED76CD2CFA CRC64;
     MPGDKQEAKN ATQKTEEGVH ITEALITKRN LTFPEDEDLS EKMFHTLDDL ETVRLDGEGI
     TCIGNLERLR NIHSLYLQSN KIQRIENLAC ITSLRFLSLA GNQIRHVENL LDLQYLQFLD
     LSENLIETLK LDELPQSLLI LNLCGNPCTN QDGYRKMVIG ALPLLLDLDK QPILERWTSD
     EEDKSSDEEE EFPELNGPFC AERGFFKDLE QELHQHQERR QQAALTEHLS RMETQPVLTD
     LPLLPAVPMA GDCSPAVTEE PGKEAAPKAT SSTQMASSSK KQVPRNQKGS VQARKGALAA
     TASKTSLAAA PSMTKSTNKR GTK