LRC47_MOUSE
ID LRC47_MOUSE Reviewed; 581 AA.
AC Q505F5; Q3U380; Q6ZPW2; Q9CUZ0;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Leucine-rich repeat-containing protein 47;
GN Name=Lrrc47; Synonyms=Kiaa1185;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-581.
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK013512; BAB28889.1; -; mRNA.
DR EMBL; AK154897; BAE32909.1; -; mRNA.
DR EMBL; BC094573; AAH94573.1; -; mRNA.
DR EMBL; AK129306; BAC98116.1; -; mRNA.
DR CCDS; CCDS19006.1; -.
DR RefSeq; NP_957678.1; NM_201226.1.
DR AlphaFoldDB; Q505F5; -.
DR SMR; Q505F5; -.
DR BioGRID; 215663; 13.
DR IntAct; Q505F5; 5.
DR MINT; Q505F5; -.
DR STRING; 10090.ENSMUSP00000133124; -.
DR iPTMnet; Q505F5; -.
DR PhosphoSitePlus; Q505F5; -.
DR REPRODUCTION-2DPAGE; Q505F5; -.
DR EPD; Q505F5; -.
DR jPOST; Q505F5; -.
DR MaxQB; Q505F5; -.
DR PaxDb; Q505F5; -.
DR PRIDE; Q505F5; -.
DR ProteomicsDB; 252670; -.
DR Antibodypedia; 1623; 32 antibodies from 13 providers.
DR DNASU; 72946; -.
DR Ensembl; ENSMUST00000030894; ENSMUSP00000030894; ENSMUSG00000029028.
DR GeneID; 72946; -.
DR KEGG; mmu:72946; -.
DR UCSC; uc008way.1; mouse.
DR CTD; 57470; -.
DR MGI; MGI:1920196; Lrrc47.
DR VEuPathDB; HostDB:ENSMUSG00000029028; -.
DR eggNOG; KOG2472; Eukaryota.
DR GeneTree; ENSGT00530000063489; -.
DR HOGENOM; CLU_034522_0_0_1; -.
DR InParanoid; Q505F5; -.
DR OMA; YDVKPPT; -.
DR OrthoDB; 1021451at2759; -.
DR PhylomeDB; Q505F5; -.
DR BioGRID-ORCS; 72946; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q505F5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q505F5; protein.
DR Bgee; ENSMUSG00000029028; Expressed in secondary oocyte and 230 other tissues.
DR ExpressionAtlas; Q505F5; baseline and differential.
DR Genevisible; Q505F5; MM.
DR GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 3.50.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR005146; B3/B4_tRNA-bd.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR045060; Phe-tRNA-ligase_IIc_bsu.
DR InterPro; IPR020825; Phe-tRNA_synthase-like_B3/B4.
DR PANTHER; PTHR10947; PTHR10947; 1.
DR Pfam; PF03483; B3_4; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00873; B3_4; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR PROSITE; PS51450; LRR; 6.
PE 1: Evidence at protein level;
KW Coiled coil; Leucine-rich repeat; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..581
FT /note="Leucine-rich repeat-containing protein 47"
FT /id="PRO_0000223927"
FT REPEAT 78..97
FT /note="LRR 1"
FT REPEAT 102..123
FT /note="LRR 2"
FT REPEAT 132..154
FT /note="LRR 3"
FT REPEAT 156..177
FT /note="LRR 4"
FT REPEAT 182..204
FT /note="LRR 5"
FT REPEAT 205..227
FT /note="LRR 6"
FT REPEAT 228..248
FT /note="LRR 7"
FT REGION 262..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 401..436
FT /evidence="ECO:0000255"
FT COMPBIAS 265..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 314
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1G4"
FT MOD_RES 430
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1G4"
FT MOD_RES 519
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1G4"
FT CONFLICT 312
FT /note="H -> Y (in Ref. 1; BAE32909)"
FT /evidence="ECO:0000305"
FT CONFLICT 487
FT /note="S -> N (in Ref. 3; BAC98116)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 581 AA; 63590 MW; A82B2503E1E41EF0 CRC64;
MAAAAMAVSE AWPELELAER ERRRELLLTG PGLEERVKAA GGRLPPRLFT LPLLHYLEVS
GCGSLRAPGP GLAQGLPQLH SLVLRRNALG PGLSPELGPL PALRVLDLSG NALETLPPGE
GLGPAEPPGL PQLQSLNLSG NRLRELPADL ARCAPRLQSL NLTGNRLDAF PPELFRPGAL
PLLSELAAAD NCLRELSPDI AHLASLKTLD LSNNQLTEIP AELADCPKLK EINFRGNRLR
DKRLEKMVGG CQTKSILEYL RAGGRGGRSK GRQEASEKED RKKRRERKQH RESGEGEEEV
ADSARLMLKV LHVSENPTPL TVRVSPEVKD VRPYIVGAIV RGMDLQPGNA LRRFLNSQTK
LHDDLCEKRT AATIATHDLQ AVRGPLLYAA RPPEDLKIVP LGRKEAKAKE LVRQLQLEAE
EQRKQKKRQS VSGLHRYLHL LDGKENYPCL VDAEGDVISF PPITNSEKTK IKKTTCNLFL
EVTSATSLQL CKDIMDSLIL RMAELSKSTS ENKEEDMLSG TEADAGCGLS DPNLTLSSGK
DGQCPLVVEQ VRVVDLEGSL KVVYPSKTDL ITLPPHVTVV R
