LRC51_MOUSE
ID LRC51_MOUSE Reviewed; 192 AA.
AC Q9DAK8; B6CZ58; B6CZ59; Q8R171;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Leucine-rich repeat-containing protein 51 {ECO:0000305};
GN Name=Lrrc51 {ECO:0000312|MGI:MGI:1916608};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=18953341; DOI=10.1038/ng.245;
RA Ahmed Z.M., Masmoudi S., Kalay E., Belyantseva I.A., Mosrati M.A.,
RA Collin R.W.J., Riazuddin S., Hmani-Aifa M., Venselaar H., Kawar M.N.,
RA Tlili A., van der Zwaag B., Khan S.Y., Ayadi L., Riazuddin S.A.,
RA Morell R.J., Griffith A.J., Charfedine I., Caylan R., Oostrik J.,
RA Karaguzel A., Ghorbel A., Riazuddin S., Friedman T.B., Ayadi H., Kremer H.;
RT "Mutations of LRTOMT, a fusion gene with alternative reading frames, cause
RT nonsyndromic deafness in humans.";
RL Nat. Genet. 40:1335-1340(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18953341}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=A;
CC IsoId=Q9DAK8-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=Q9DAK8-2; Sequence=VSP_036897;
CC -!- TISSUE SPECIFICITY: Widely expressed in adult and embryonic tissues.
CC Expressed in the developing choroid plexus from 12.5 dpc and in the
CC epithelium of the developing airway tract from 14.5 dpc. Also expressed
CC in the postnatal inner ear. {ECO:0000269|PubMed:18953341}.
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DR EMBL; EU627089; ACF40899.1; -; mRNA.
DR EMBL; EU627090; ACF40900.1; -; mRNA.
DR EMBL; AK005758; BAB24223.1; -; mRNA.
DR EMBL; CH466531; EDL16549.1; -; Genomic_DNA.
DR EMBL; CH466531; EDL16550.1; -; Genomic_DNA.
DR EMBL; CH466531; EDL16551.1; -; Genomic_DNA.
DR EMBL; BC025128; AAH25128.1; -; mRNA.
DR CCDS; CCDS52331.1; -. [Q9DAK8-2]
DR CCDS; CCDS52332.1; -. [Q9DAK8-1]
DR RefSeq; NP_001156446.1; NM_001162974.1. [Q9DAK8-2]
DR RefSeq; NP_081329.1; NM_027053.1.
DR AlphaFoldDB; Q9DAK8; -.
DR SMR; Q9DAK8; -.
DR STRING; 10090.ENSMUSP00000077543; -.
DR PhosphoSitePlus; Q9DAK8; -.
DR PaxDb; Q9DAK8; -.
DR PRIDE; Q9DAK8; -.
DR ProteomicsDB; 252507; -. [Q9DAK8-1]
DR ProteomicsDB; 252508; -. [Q9DAK8-2]
DR Antibodypedia; 34978; 61 antibodies from 17 providers.
DR DNASU; 69358; -.
DR Ensembl; ENSMUST00000098236; ENSMUSP00000095838; ENSMUSG00000064307. [Q9DAK8-2]
DR Ensembl; ENSMUST00000106963; ENSMUSP00000102576; ENSMUSG00000064307. [Q9DAK8-2]
DR Ensembl; ENSMUST00000106964; ENSMUSP00000102577; ENSMUSG00000064307. [Q9DAK8-2]
DR Ensembl; ENSMUST00000163903; ENSMUSP00000129333; ENSMUSG00000064307. [Q9DAK8-2]
DR GeneID; 69358; -.
DR KEGG; mmu:69358; -.
DR UCSC; uc009ipx.2; mouse. [Q9DAK8-1]
DR CTD; 120356739; -.
DR MGI; MGI:1916608; Lrrc51.
DR VEuPathDB; HostDB:ENSMUSG00000064307; -.
DR eggNOG; KOG1644; Eukaryota.
DR GeneTree; ENSGT00510000047925; -.
DR HOGENOM; CLU_095080_1_1_1; -.
DR InParanoid; Q9DAK8; -.
DR OMA; HQSNSRC; -.
DR OrthoDB; 1447031at2759; -.
DR PhylomeDB; Q9DAK8; -.
DR BioGRID-ORCS; 69358; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Lrrc51; mouse.
DR PRO; PR:Q9DAK8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9DAK8; protein.
DR Bgee; ENSMUSG00000064307; Expressed in seminiferous tubule of testis and 147 other tissues.
DR ExpressionAtlas; Q9DAK8; baseline and differential.
DR Genevisible; Q9DAK8; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043196; LRTOMT1.
DR PANTHER; PTHR46545; PTHR46545; 1.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Leucine-rich repeat; Reference proteome;
KW Repeat.
FT CHAIN 1..192
FT /note="Leucine-rich repeat-containing protein 51"
FT /id="PRO_0000225501"
FT REPEAT 49..71
FT /note="LRR 1"
FT REPEAT 80..101
FT /note="LRR 2"
FT REPEAT 103..124
FT /note="LRR 3"
FT DOMAIN 137..175
FT /note="LRRCT"
FT VAR_SEQ 147..192
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:18953341"
FT /id="VSP_036897"
SQ SEQUENCE 192 AA; 22008 MW; 8AA9D7074874AD52 CRC64;
MSSRDYMNTS VQEPPLDYSF KSVQMVQDLV TEEPRTGLRP VRHSKSGKSL TQSLWLNNNV
LNDLKDFNQV VSQLLQHPEN LAWIDLSFND LTTIDPVLTT FFNLSVLYLH GNGIHRLGEV
NKLAVLPRLR SLTLHGNPIE EEKGYRQYVL CNLPRITTFD FSGVTRADRS TAEVWKRMGI
KPKKVRAKQD VL
