ID   LRC51_PROCO             Reviewed;         192 AA.
AC   B6CZ54; B6CZ55;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Leucine-rich repeat-containing protein 51 {ECO:0000250|UniProtKB:Q96E66};
DE   AltName: Full=Protein LRTOMT1 {ECO:0000303|PubMed:18953341};
GN   Name=LRRC51 {ECO:0000250|UniProtKB:Q96E66};
GN   Synonyms=LRTOMT {ECO:0000303|PubMed:18953341};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ACF40895.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain {ECO:0000312|EMBL:ACF40895.1};
RX   PubMed=18953341; DOI=10.1038/ng.245;
RA   Ahmed Z.M., Masmoudi S., Kalay E., Belyantseva I.A., Mosrati M.A.,
RA   Collin R.W.J., Riazuddin S., Hmani-Aifa M., Venselaar H., Kawar M.N.,
RA   Tlili A., van der Zwaag B., Khan S.Y., Ayadi L., Riazuddin S.A.,
RA   Morell R.J., Griffith A.J., Charfedine I., Caylan R., Oostrik J.,
RA   Karaguzel A., Ghorbel A., Riazuddin S., Friedman T.B., Ayadi H., Kremer H.;
RT   "Mutations of LRTOMT, a fusion gene with alternative reading frames, cause
RT   nonsyndromic deafness in humans.";
RL   Nat. Genet. 40:1335-1340(2008).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9DAK8}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1 {ECO:0000269|PubMed:18953341}; Synonyms=A
CC       {ECO:0000269|PubMed:18953341};
CC         IsoId=B6CZ54-1; Sequence=Displayed;
CC       Name=2 {ECO:0000269|PubMed:18953341}; Synonyms=B
CC       {ECO:0000269|PubMed:18953341};
CC         IsoId=B6CZ54-2; Sequence=VSP_053066, VSP_053067;
CC   -!- MISCELLANEOUS: LRRC51 and TOMT were originally considered as
CC       alternative reading frames, LRTOMT1 and LRTOMT2 of the same LRTOMT gene
CC       in primates. {ECO:0000303|PubMed:18953341}.
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DR   EMBL; EU627085; ACF40895.1; -; mRNA.
DR   EMBL; EU627086; ACF40896.1; -; mRNA.
DR   AlphaFoldDB; B6CZ54; -.
DR   SMR; B6CZ54; -.
DR   Proteomes; UP000233160; Whole Genome Shotgun Assembly.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR043196; LRTOMT1.
DR   PANTHER; PTHR46545; PTHR46545; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Leucine-rich repeat; Reference proteome;
KW   Repeat.
FT   CHAIN           1..192
FT                   /note="Leucine-rich repeat-containing protein 51"
FT                   /id="PRO_0000370743"
FT   REPEAT          49..71
FT                   /note="LRR 1"
FT   REPEAT          80..101
FT                   /note="LRR 2"
FT   REPEAT          103..124
FT                   /note="LRR 3"
FT   DOMAIN          137..175
FT                   /note="LRRCT"
FT   VAR_SEQ         25..52
FT                   /note="VIQDLVNEEPRTGLRPLKRSKSGKSLTQ -> IIQGPNNFLQPECPLSSRQQ
FT                   HPAPGGGE (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:18953341"
FT                   /id="VSP_053066"
FT   VAR_SEQ         53..192
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:18953341"
FT                   /id="VSP_053067"
SQ   SEQUENCE   192 AA;  22160 MW;  CD3A16A0DD1E82BD CRC64;
     MNKRDYMNTS VQEPPLDYSF RSIHVIQDLV NEEPRTGLRP LKRSKSGKSL TQSLWLNNNV
     LNDLRDFNQV ASQLLEHPEN LAWIDLSFND LTSIDPVLTT FFNLSVLYLH GNSIQHLGEV
     NKLAVLPRLR SLTLHGNPME EEKGYRQYVL CTLPHITTFD FSGVTKADRT TAEVWKRMNI
     KPKKARIKQN TL