ID   LRC51_RAT               Reviewed;         192 AA.
AC   B6CZ61;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Leucine-rich repeat-containing protein 51 {ECO:0000312|RGD:1565856};
GN   Name=Lrrc51 {ECO:0000312|RGD:1565856};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:ACF40902.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:ACF40902.1};
RC   TISSUE=Brain {ECO:0000312|EMBL:ACF40902.1};
RX   PubMed=18953341; DOI=10.1038/ng.245;
RA   Ahmed Z.M., Masmoudi S., Kalay E., Belyantseva I.A., Mosrati M.A.,
RA   Collin R.W.J., Riazuddin S., Hmani-Aifa M., Venselaar H., Kawar M.N.,
RA   Tlili A., van der Zwaag B., Khan S.Y., Ayadi L., Riazuddin S.A.,
RA   Morell R.J., Griffith A.J., Charfedine I., Caylan R., Oostrik J.,
RA   Karaguzel A., Ghorbel A., Riazuddin S., Friedman T.B., Ayadi H., Kremer H.;
RT   "Mutations of LRTOMT, a fusion gene with alternative reading frames, cause
RT   nonsyndromic deafness in humans.";
RL   Nat. Genet. 40:1335-1340(2008).
RN   [2] {ECO:0000312|EMBL:EDM18240.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9DAK8}.
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DR   EMBL; EU627092; ACF40902.1; -; mRNA.
DR   EMBL; CH473956; EDM18240.1; -; Genomic_DNA.
DR   RefSeq; NP_001099754.1; NM_001106284.1.
DR   RefSeq; XP_006229932.1; XM_006229870.3.
DR   RefSeq; XP_006229933.1; XM_006229871.3.
DR   RefSeq; XP_006229934.1; XM_006229872.3.
DR   RefSeq; XP_006229935.1; XM_006229873.3.
DR   RefSeq; XP_006229936.1; XM_006229874.3.
DR   RefSeq; XP_006229937.1; XM_006229875.3.
DR   RefSeq; XP_017444456.1; XM_017588967.1.
DR   AlphaFoldDB; B6CZ61; -.
DR   SMR; B6CZ61; -.
DR   STRING; 10116.ENSRNOP00000027261; -.
DR   PaxDb; B6CZ61; -.
DR   Ensembl; ENSRNOT00000027261; ENSRNOP00000027261; ENSRNOG00000020124.
DR   GeneID; 293156; -.
DR   KEGG; rno:293156; -.
DR   UCSC; RGD:1565856; rat.
DR   CTD; 120356739; -.
DR   RGD; 1565856; Lrrc51.
DR   eggNOG; KOG1644; Eukaryota.
DR   GeneTree; ENSGT00510000047925; -.
DR   HOGENOM; CLU_095080_1_1_1; -.
DR   InParanoid; B6CZ61; -.
DR   OMA; HQSNSRC; -.
DR   OrthoDB; 1447031at2759; -.
DR   PhylomeDB; B6CZ61; -.
DR   TreeFam; TF329158; -.
DR   PRO; PR:B6CZ61; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Proteomes; UP000234681; Chromosome 1.
DR   Bgee; ENSRNOG00000020124; Expressed in testis and 19 other tissues.
DR   Genevisible; B6CZ61; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR043196; LRTOMT1.
DR   PANTHER; PTHR46545; PTHR46545; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..192
FT                   /note="Leucine-rich repeat-containing protein 51"
FT                   /id="PRO_0000370744"
FT   REPEAT          49..71
FT                   /note="LRR 1"
FT   REPEAT          80..101
FT                   /note="LRR 2"
FT   REPEAT          103..124
FT                   /note="LRR 3"
FT   DOMAIN          137..175
FT                   /note="LRRCT"
SQ   SEQUENCE   192 AA;  22162 MW;  818824CC7D76A591 CRC64;
     MSKRDYMNTS VQEPPLDYSF KSVQMIQDLI SEEPRTGLRP VKYSKSGKSL TQSLWLNNNV
     LNDLKDFNQV VSQLLQHPEN LAWIDLSFND LTTIDPVLTT FFNLSVLYLH GNSIHRLGEV
     NKLAVLPRLR SLTLHGNPIE EEKGYRQYVL CNLPRITTFD FSGVTKADRS TAEVWKRMNI
     KPKKVRIKQD VL