LRC53_HUMAN
ID LRC53_HUMAN Reviewed; 1247 AA.
AC A6NM62;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Leucine-rich repeat-containing protein 53;
GN Name=LRRC53;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AC105271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016858569.1; XM_017003080.1.
DR AlphaFoldDB; A6NM62; -.
DR SMR; A6NM62; -.
DR iPTMnet; A6NM62; -.
DR PhosphoSitePlus; A6NM62; -.
DR BioMuta; LRRC53; -.
DR jPOST; A6NM62; -.
DR PaxDb; A6NM62; -.
DR PeptideAtlas; A6NM62; -.
DR PRIDE; A6NM62; -.
DR ProteomicsDB; 1517; -.
DR Antibodypedia; 66009; 7 antibodies from 3 providers.
DR Ensembl; ENST00000294635.5; ENSP00000294635.4; ENSG00000162621.7.
DR MANE-Select; ENST00000294635.5; ENSP00000294635.4; NM_001382280.1; NP_001369209.1.
DR UCSC; uc057hqj.1; human.
DR GeneCards; LRRC53; -.
DR HGNC; HGNC:25255; LRRC53.
DR HPA; ENSG00000162621; Tissue enriched (brain).
DR neXtProt; NX_A6NM62; -.
DR VEuPathDB; HostDB:ENSG00000162621; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000161095; -.
DR HOGENOM; CLU_280737_0_0_1; -.
DR InParanoid; A6NM62; -.
DR OMA; WKQQKNQ; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; A6NM62; -.
DR TreeFam; TF341942; -.
DR PathwayCommons; A6NM62; -.
DR SignaLink; A6NM62; -.
DR BioGRID-ORCS; 105378803; 2 hits in 124 CRISPR screens.
DR Pharos; A6NM62; Tdark.
DR PRO; PR:A6NM62; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A6NM62; protein.
DR Bgee; ENSG00000162621; Expressed in calcaneal tendon and 16 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 6.
DR PROSITE; PS51450; LRR; 7.
PE 4: Predicted;
KW Leucine-rich repeat; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1247
FT /note="Leucine-rich repeat-containing protein 53"
FT /id="PRO_0000317367"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 34..55
FT /note="LRR 1"
FT REPEAT 58..79
FT /note="LRR 2"
FT REPEAT 82..102
FT /note="LRR 3"
FT REPEAT 108..129
FT /note="LRR 4"
FT REPEAT 132..153
FT /note="LRR 5"
FT REPEAT 158..179
FT /note="LRR 6"
FT REPEAT 182..203
FT /note="LRR 7"
FT DOMAIN 214..271
FT /note="LRRCT"
FT REGION 828..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1223..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1247 AA; 140742 MW; A22DDB8BB3BEA9B3 CRC64;
MLRLVAACPE SCVVCTKDVT LCHQLTYIVA APMTTRVLII TDGYLSSIES TNLSLLFNLA
LLSLSRNGIE DVQEDALHGL TMLRTLLLEH NQISSSSLTD HTFSKLHSLQ VLVLSNNALR
TLRGSWFRNT SGLTRLQLDG NQITNLTDSS FGGTNLHSLR YLDLSNNFIS YIGKDAFRPL
PQLQEVDLSR NRLAHMPDVF TPLKQLILLS LDKNQWSCTC DLHPLARFLR NYIKSSAHTL
RNAKDLNCQP STAAVAAAQS VLRLSETNCD SKAPNFTLVL KDRSPLLPGP DVALLTVLGF
AGAVGLTCLG LVVFNWKLHQ GKANEHTSEN LCCRTFDEPL CAHEARNYHT KGYCNCHLTQ
ENEIKVMSTV GSRKEMPLLQ ENSHQATSAS ESATLDGSFR NLKKKDRGVG STLFCQDGRL
LHSECSEPPG NMRAFNEAGL LTTYNPRKVQ KLWNLEPGEV QPQTLQHHII RTEDISSDIF
RRRYATPASA LAGESLEKRL TNESWQPPIE KEDNGLHPHR QRHFITSSSS KPCEPEEHYV
QKIVQKNRSK YDDPCGLLKQ SKPRYFQPNN SLICKYVPCE QFEDYMKEKK PNRRQHSKPE
KEQIQINSAI EKFLMSEDNI DLSGLSTKTK KAYSPKRVIF HDPDLVEINR SMMSPKISTP
WKRQKNQSNQ LTKLDVKKFS NTGERNKGEK WFTNSWVLKR KRTPQSDLKG KIKGQNLKLN
LHPFRKVRVH PEKSLSSLPK QCKQVLLPPK KLSKTSETEA KINTVCSADF LQQSESSNYV
RLTSKRLPLK HDSKQTPYYQ RNTKRAPLLS ANNLRVVNQS SIESSCYSAG HIPDGNTSKL
PQPTPTDAEH RHSHSQFSTE QMEDATQLES KVLSYLATTW ENTGSDVLPF QHSRRATDQG
TTESTEHMGQ NVSKTSELNQ FSLSPRNQTQ LLDAHKTDSY NKEYTLDQNE ALQHREQNSS
HAQLENKEKT LMTKPQISHQ IVENCIMDKE ENDVEKKLSK TETYDSSLIP QTQSKNNLSF
MKTNSIPYQN RIELPKDIST SPVSSQAVWH LTNSSEKGID STNALPRNDG TEALEIKIVG
KEEKNMLDES KTDSSMLTQI SQMTLKGITK ERQQTWENGT SEKYILHDAS SAEETITAKD
LSITSSHETQ NRILCSEVDP EVNSNVHNFR EVQNIQPDKD SAHKEGAMTV ETHEALSFLP
GLKDSFEAEN EVFLVPSRIN EAENSAPKPV LYPPSAEYAT TSPLETE
