ID   LRC53_MACFA             Reviewed;         510 AA.
AC   Q9BGY6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Leucine-rich repeat-containing protein 53;
GN   Name=LRRC53; ORFNames=QflA-11149;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RX   PubMed=11806829; DOI=10.1186/gb-2001-3-1-research0006;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Prediction of unidentified human genes on the basis of sequence similarity
RT   to novel cDNAs from cynomolgus monkey brain.";
RL   Genome Biol. 3:RESEARCH0006.1-RESEARCH0006.5(2002).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AB055271; BAB21895.1; -; mRNA.
DR   AlphaFoldDB; Q9BGY6; -.
DR   SMR; Q9BGY6; -.
DR   STRING; 9541.XP_005543078.1; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 6.
DR   PROSITE; PS51450; LRR; 7.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..510
FT                   /note="Leucine-rich repeat-containing protein 53"
FT                   /id="PRO_0000317368"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          34..55
FT                   /note="LRR 1"
FT   REPEAT          58..79
FT                   /note="LRR 2"
FT   REPEAT          82..102
FT                   /note="LRR 3"
FT   REPEAT          108..129
FT                   /note="LRR 4"
FT   REPEAT          132..153
FT                   /note="LRR 5"
FT   REPEAT          158..179
FT                   /note="LRR 6"
FT   REPEAT          182..203
FT                   /note="LRR 7"
FT   DOMAIN          214..271
FT                   /note="LRRCT"
SQ   SEQUENCE   510 AA;  56496 MW;  FF52698C2F9119E8 CRC64;
     MLQLVAACPE SCVVCTKDVT LCHQLTYIVA APMTTRVLII TDGYLSSIES TNLSLLFNLA
     LLSLSRNGIE DVQEDALDGL TMLRTLLLEH NQISSSSLTD HTFSKLHSLQ VLVLSNNALR
     TLRGSWFRNT RGLTRLQLDG NQITNLTDSS FGGTNLHSLR HLDLSNNFIS YIGKDAFRPL
     PQLQEVDLSR NRLAHMPDVF TPLKQLIHLS LDKNQWSCTC DLHPLARFLR NYIKSSAHTL
     RNAKDLNCQP STAAVAAAQS VLRLSETNCD PKAPNFTLVL KDRSPLLPGQ DVALLTVLGF
     AGAVGLTCLG LVVFNWKLQQ GKANEHTSEN LCCRTFDEPL CAHGARNYHT KGYCNCHLTQ
     ENEIKVMSIV GSRKEMPLLQ ENSHQATSAS ESTTLDGSFR NLKKKDHGVG STLFCQDGRL
     LHSRCSQSPG NTTAFNEAGL LTTYNSRKVQ KLRNLESGEV LPQTLPHHII RTEDISSDTF
     RRRYAIPTSA LAGESLEKHL TNESCLHTLN