ID   LRC55_RAT               Reviewed;         298 AA.
AC   Q4KLL3;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2018, sequence version 3.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Leucine-rich repeat-containing protein 55;
DE   AltName: Full=BK channel auxiliary gamma subunit LRRC55;
DE   Flags: Precursor;
GN   Name=Lrrc55;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Auxiliary protein of the large-conductance, voltage and
CC       calcium-activated potassium channel (BK alpha). Modulates gating
CC       properties by producing a marked shift in the BK channel's voltage
CC       dependence of activation in the hyperpolarizing direction, and in the
CC       absence of calcium (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with KCNMA1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}.
CC   -!- DOMAIN: The transmembrane domain is necessary for interaction with
CC       KCNMA1. {ECO:0000250}.
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DR   EMBL; BC099134; AAH99134.2; -; mRNA.
DR   RefSeq; NP_001116447.1; NM_001122975.1.
DR   RefSeq; XP_006234534.1; XM_006234472.3.
DR   RefSeq; XP_017447203.1; XM_017591714.1.
DR   AlphaFoldDB; Q4KLL3; -.
DR   SMR; Q4KLL3; -.
DR   STRING; 10116.ENSRNOP00000034072; -.
DR   PaxDb; Q4KLL3; -.
DR   GeneID; 311171; -.
DR   KEGG; rno:311171; -.
DR   UCSC; RGD:1561726; rat.
DR   CTD; 219527; -.
DR   RGD; 1561726; Lrrc55.
DR   eggNOG; KOG0619; Eukaryota.
DR   HOGENOM; CLU_000288_18_10_1; -.
DR   InParanoid; Q4KLL3; -.
DR   OrthoDB; 826997at2759; -.
DR   PhylomeDB; Q4KLL3; -.
DR   TreeFam; TF334689; -.
DR   PRO; PR:Q4KLL3; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; ISO:RGD.
DR   GO; GO:0099104; F:potassium channel activator activity; ISO:RGD.
DR   GO; GO:0044325; F:transmembrane transporter binding; ISO:RGD.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; ISO:RGD.
DR   GO; GO:1903818; P:positive regulation of voltage-gated potassium channel activity; ISO:RGD.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; ISO:RGD.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Ion channel; Ion transport;
KW   Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000250"
FT   CHAIN           35..298
FT                   /note="Leucine-rich repeat-containing protein 55"
FT                   /id="PRO_0000232915"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          35..65
FT                   /note="LRRNT"
FT   REPEAT          66..87
FT                   /note="LRR 1"
FT   REPEAT          90..111
FT                   /note="LRR 2"
FT   REPEAT          114..135
FT                   /note="LRR 3"
FT   REPEAT          138..160
FT                   /note="LRR 4"
FT   REPEAT          163..186
FT                   /note="LRR 5"
FT   DOMAIN          196..251
FT                   /note="LRRCT"
FT   DISULFID        38..44
FT                   /evidence="ECO:0000255"
FT   DISULFID        42..51
FT                   /evidence="ECO:0000255"
FT   DISULFID        200..227
FT                   /evidence="ECO:0000255"
FT   DISULFID        202..249
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   298 AA;  33000 MW;  E094A698B28E02E7 CRC64;
     MGDTWAQLPW PGPPHSALLL VFFLLAAGVM HSDAGASCPV LCTCRNQVVD CSNQRLFSVP
     PDLPMDTRNL SLAHNRIAAV PPGYLTCYME LRVLDLRNNS LMELPPGLFL HAKRLAHLDL
     SYNNLSHVPA DMFREAHGLV HIDLSHNPWL RRVHPQAFQG LVHLRDLDLS YGGLAFLSLE
     ALEGLPGLVT LQIGGNPWVC GCTMEPLLKW LRNRIQRCTA DSQLAECRGP PEVEGAPLFS
     LTEESFKACH LTLTLDDYLF IAFVGFVVSI ASVATNFLLG ITANCCHRWS KANEEEEI