ID   LRC56_MOUSE             Reviewed;         552 AA.
AC   Q8K375; Q571F2;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Leucine-rich repeat-containing protein 56;
GN   Name=Lrrc56;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pancreatic islet;
RA   Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA   Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT   complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT   screening of terminal sequences of cDNA clones randomly sampled from size-
RT   fractionated libraries.";
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for the assembly of dynein arms.
CC       {ECO:0000250|UniProtKB:Q387Y5}.
CC   -!- SUBUNIT: Interacts with IFT88. {ECO:0000250|UniProtKB:Q8IYG6}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q387Y5}.
CC   -!- SIMILARITY: Belongs to the LRRC56 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD90162.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK220237; BAD90162.1; ALT_INIT; mRNA.
DR   EMBL; BC027807; AAH27807.1; -; mRNA.
DR   CCDS; CCDS22004.1; -.
DR   RefSeq; NP_001165535.1; NM_001172064.1.
DR   RefSeq; NP_722472.1; NM_153777.2.
DR   RefSeq; XP_006536306.1; XM_006536243.2.
DR   AlphaFoldDB; Q8K375; -.
DR   SMR; Q8K375; -.
DR   STRING; 10090.ENSMUSP00000063912; -.
DR   iPTMnet; Q8K375; -.
DR   PhosphoSitePlus; Q8K375; -.
DR   PaxDb; Q8K375; -.
DR   PRIDE; Q8K375; -.
DR   ProteomicsDB; 290158; -.
DR   Antibodypedia; 22521; 34 antibodies from 15 providers.
DR   DNASU; 70552; -.
DR   Ensembl; ENSMUST00000047093; ENSMUSP00000048691; ENSMUSG00000038637.
DR   Ensembl; ENSMUST00000070458; ENSMUSP00000063912; ENSMUSG00000038637.
DR   GeneID; 70552; -.
DR   KEGG; mmu:70552; -.
DR   UCSC; uc009kjx.2; mouse.
DR   CTD; 115399; -.
DR   MGI; MGI:1917802; Lrrc56.
DR   VEuPathDB; HostDB:ENSMUSG00000038637; -.
DR   eggNOG; KOG0531; Eukaryota.
DR   GeneTree; ENSGT00390000001545; -.
DR   HOGENOM; CLU_031382_2_0_1; -.
DR   InParanoid; Q8K375; -.
DR   OMA; NPTKGLW; -.
DR   OrthoDB; 1557546at2759; -.
DR   PhylomeDB; Q8K375; -.
DR   TreeFam; TF326690; -.
DR   BioGRID-ORCS; 70552; 3 hits in 71 CRISPR screens.
DR   ChiTaRS; Lrrc56; mouse.
DR   PRO; PR:Q8K375; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q8K375; protein.
DR   Bgee; ENSMUSG00000038637; Expressed in spermatocyte and 152 other tissues.
DR   ExpressionAtlas; Q8K375; baseline and differential.
DR   Genevisible; Q8K375; MM.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR040091; LRRC56.
DR   PANTHER; PTHR22708; PTHR22708; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..552
FT                   /note="Leucine-rich repeat-containing protein 56"
FT                   /id="PRO_0000229924"
FT   REPEAT          94..115
FT                   /note="LRR 1"
FT   REPEAT          117..138
FT                   /note="LRR 2"
FT   REPEAT          139..160
FT                   /note="LRR 3"
FT   REPEAT          161..182
FT                   /note="LRR 4"
FT   REPEAT          186..206
FT                   /note="LRR 5"
FT   REGION          348..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          401..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   552 AA;  60483 MW;  EBEFB7A91D237874 CRC64;
     MDPAWDGSQG SRPGTASIRV RELSWQGLNN PHPQNKRLGS HGDIHRERWV EERLSPARLQ
     ALAQVDDLQL VRVLEMCVDT RKNSLGNFGL YLPNLIQLKL NHSYLGSLRD LGTSLGHLQV
     LWLARCGLTD LDGIGSFLEL KELYVSYNNI SDLSPLCLLE QLEVLDLEGN NVEDLGQMRY
     LQLCPRLAML TLEGNLVCLK PDPGPSNKAP QGYNYRAEVK KLIPQLHVLD EVPTTCTSAP
     APQTLSQDWL MVKEAIKEGS VLDILLPRLD DPHGATIRKF DPTLPVPETQ PWALSLLVPG
     GPLPEGLLSE NPATEDHASN LTHGPGQVLC GNPTKGLRKR RNQYQEWAPL EQMPPHRPDL
     AIRPSTPRPD PAESCDLAMT GLRAWTEPGL RPLLQRQLEF QQERSAQVQA QDPQKDPVEQ
     EDQTGPKTSL TPPRLVSELS RTSGFHLIPS PPKYPMPPES GISSLGRSAD LPFRGRRLRV
     LGSLGPSLGE GSVLGERLAA VTALRALEAS SGPSHRAQGC PDPKPALGPA ACPPGLHCLH
     HLNPIPPAHS LP