ID   LRC56_RAT               Reviewed;         548 AA.
AC   Q4V8C9;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Leucine-rich repeat-containing protein 56;
GN   Name=Lrrc56;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for the assembly of dynein arms.
CC       {ECO:0000250|UniProtKB:Q387Y5}.
CC   -!- SUBUNIT: Interacts with IFT88. {ECO:0000250|UniProtKB:Q8IYG6}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q387Y5}.
CC   -!- SIMILARITY: Belongs to the LRRC56 family. {ECO:0000305}.
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DR   EMBL; BC097444; AAH97444.1; -; mRNA.
DR   RefSeq; NP_001020073.1; NM_001024902.1.
DR   RefSeq; XP_006230626.1; XM_006230564.3.
DR   RefSeq; XP_006230627.1; XM_006230565.3.
DR   RefSeq; XP_006230628.1; XM_006230566.3.
DR   AlphaFoldDB; Q4V8C9; -.
DR   SMR; Q4V8C9; -.
DR   STRING; 10116.ENSRNOP00000022867; -.
DR   PaxDb; Q4V8C9; -.
DR   Ensembl; ENSRNOT00000022867; ENSRNOP00000022867; ENSRNOG00000016697.
DR   GeneID; 365389; -.
DR   KEGG; rno:365389; -.
DR   UCSC; RGD:1311654; rat.
DR   CTD; 115399; -.
DR   RGD; 1311654; Lrrc56.
DR   eggNOG; KOG0531; Eukaryota.
DR   GeneTree; ENSGT00390000001545; -.
DR   InParanoid; Q4V8C9; -.
DR   OMA; NPTKGLW; -.
DR   OrthoDB; 1557546at2759; -.
DR   PhylomeDB; Q4V8C9; -.
DR   TreeFam; TF326690; -.
DR   PRO; PR:Q4V8C9; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000016697; Expressed in testis and 19 other tissues.
DR   ExpressionAtlas; Q4V8C9; baseline and differential.
DR   Genevisible; Q4V8C9; RN.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR040091; LRRC56.
DR   PANTHER; PTHR22708; PTHR22708; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..548
FT                   /note="Leucine-rich repeat-containing protein 56"
FT                   /id="PRO_0000229925"
FT   REPEAT          94..115
FT                   /note="LRR 1"
FT   REPEAT          117..138
FT                   /note="LRR 2"
FT   REPEAT          139..160
FT                   /note="LRR 3"
FT   REPEAT          161..182
FT                   /note="LRR 4"
FT   REPEAT          186..206
FT                   /note="LRR 5"
FT   DOMAIN          207..249
FT                   /note="LRRCT"
FT   REGION          405..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..433
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   548 AA;  60488 MW;  2F7CF97ED29146B2 CRC64;
     MDPAWDGSQG SRPGTASIRV RELSWQGLNN PQPQNKRLGS HGDIYRERRV EEHLSPARLQ
     ALAQVDDLQL VRVLEMCVDT RKNSLGNFGM HLPNLIQLKL NHSCLGSLRD LGTSLGQLQV
     LWLARCGLTD LDGIGSFLAL KELYVSYNNI SDLSPLCLLE QLEVLDLEGN NVEDLGQMRY
     LQLCPRLTTL TLEGNLVCLK PDPGPSNKAP QDYNYRAEVK KLIPQLHILD EVPTTCTNLP
     APQKLSQDWL MVKEAIKEGN VLDILLPRLE CSHGATIRKF DPTLPVPETQ PWALSLLVPE
     GPLPEGLLSE NPAAEDHASN LTHGPGQVLC GNPTKGLRER RNQYQEWAPL EQLPPHRPDL
     AIRPSTLRPD PAESCDLSMT GLRAWREPGL RPLLQRQLEF QQERLTHVQA QDPQKAPIEQ
     EDQTGPKTSL TPLRLASELS RTSGFHLIPS PPKYPMPPES GISSLGRSAD LPFRGRRLRV
     LGSLGPSLGE GSVLGERLAL RALEVSSDPS HRAQGCPDPK PSLGPATCPL GLHCLHHLNP
     IPPAHPFP