LRC57_HUMAN
ID LRC57_HUMAN Reviewed; 239 AA.
AC Q8N9N7; Q7Z2Z6; Q8N1T6;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Leucine-rich repeat-containing protein 57;
GN Name=LRRC57;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Corpus callosum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Endometrium, and Uterine endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP MYRISTOYLATION AT GLY-2, CLEAVAGE OF INITIATOR METHIONINE, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=25255805; DOI=10.1038/ncomms5919;
RA Thinon E., Serwa R.A., Broncel M., Brannigan J.A., Brassat U., Wright M.H.,
RA Heal W.P., Wilkinson A.J., Mann D.J., Tate E.W.;
RT "Global profiling of co- and post-translationally N-myristoylated proteomes
RT in human cells.";
RL Nat. Commun. 5:4919-4919(2014).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
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DR EMBL; AK094131; BAC04294.1; -; mRNA.
DR EMBL; AK094891; BAC04451.1; -; mRNA.
DR EMBL; CR749223; CAH18079.1; -; mRNA.
DR EMBL; BX538324; CAD98097.1; -; mRNA.
DR EMBL; BC058935; AAH58935.1; -; mRNA.
DR CCDS; CCDS10089.1; -.
DR RefSeq; NP_694992.2; NM_153260.2.
DR AlphaFoldDB; Q8N9N7; -.
DR SMR; Q8N9N7; -.
DR BioGRID; 129089; 41.
DR IntAct; Q8N9N7; 10.
DR MINT; Q8N9N7; -.
DR STRING; 9606.ENSP00000326817; -.
DR iPTMnet; Q8N9N7; -.
DR PhosphoSitePlus; Q8N9N7; -.
DR BioMuta; LRRC57; -.
DR DMDM; 74760039; -.
DR EPD; Q8N9N7; -.
DR jPOST; Q8N9N7; -.
DR MassIVE; Q8N9N7; -.
DR MaxQB; Q8N9N7; -.
DR PaxDb; Q8N9N7; -.
DR PeptideAtlas; Q8N9N7; -.
DR PRIDE; Q8N9N7; -.
DR ProteomicsDB; 72569; -.
DR Antibodypedia; 23691; 147 antibodies from 18 providers.
DR DNASU; 255252; -.
DR Ensembl; ENST00000323443.6; ENSP00000326817.2; ENSG00000180979.10.
DR Ensembl; ENST00000397130.8; ENSP00000380319.3; ENSG00000180979.10.
DR Ensembl; ENST00000563454.5; ENSP00000455445.1; ENSG00000180979.10.
DR GeneID; 255252; -.
DR KEGG; hsa:255252; -.
DR MANE-Select; ENST00000397130.8; ENSP00000380319.3; NM_153260.3; NP_694992.2.
DR UCSC; uc001zqc.4; human.
DR CTD; 255252; -.
DR DisGeNET; 255252; -.
DR GeneCards; LRRC57; -.
DR HGNC; HGNC:26719; LRRC57.
DR HPA; ENSG00000180979; Low tissue specificity.
DR neXtProt; NX_Q8N9N7; -.
DR OpenTargets; ENSG00000180979; -.
DR PharmGKB; PA142671516; -.
DR VEuPathDB; HostDB:ENSG00000180979; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157393; -.
DR InParanoid; Q8N9N7; -.
DR OMA; CCASNQG; -.
DR OrthoDB; 1348484at2759; -.
DR PhylomeDB; Q8N9N7; -.
DR TreeFam; TF326481; -.
DR PathwayCommons; Q8N9N7; -.
DR SignaLink; Q8N9N7; -.
DR BioGRID-ORCS; 255252; 22 hits in 1082 CRISPR screens.
DR ChiTaRS; LRRC57; human.
DR GeneWiki; LRRC57; -.
DR GenomeRNAi; 255252; -.
DR Pharos; Q8N9N7; Tdark.
DR PRO; PR:Q8N9N7; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q8N9N7; protein.
DR Bgee; ENSG00000180979; Expressed in amniotic fluid and 176 other tissues.
DR ExpressionAtlas; Q8N9N7; baseline and differential.
DR Genevisible; Q8N9N7; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 5.
DR PROSITE; PS51450; LRR; 7.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Lipoprotein; Membrane; Myristate; Reference proteome;
KW Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:25255805"
FT CHAIN 2..239
FT /note="Leucine-rich repeat-containing protein 57"
FT /id="PRO_0000227778"
FT REPEAT 39..60
FT /note="LRR 1"
FT REPEAT 63..84
FT /note="LRR 2"
FT REPEAT 86..107
FT /note="LRR 3"
FT REPEAT 109..131
FT /note="LRR 4"
FT REPEAT 132..153
FT /note="LRR 5"
FT REPEAT 154..175
FT /note="LRR 6"
FT REPEAT 177..197
FT /note="LRR 7"
FT REPEAT 202..222
FT /note="LRR 8"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000269|PubMed:25255805"
FT CONFLICT 71
FT /note="N -> S (in Ref. 2; CAD98097)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="K -> N (in Ref. 1; BAC04451)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 239 AA; 26754 MW; 8CA6E06075D10E3D CRC64;
MGNSALRAHV ETAQKTGVFQ LKDRGLTEFP ADLQKLTSNL RTIDLSNNKI ESLPPLLIGK
FTLLKSLSLN NNKLTVLPDE ICNLKKLETL SLNNNHLREL PSTFGQLSAL KTLSLSGNQL
GALPPQLCSL RHLDVMDLSK NQIRSIPDSV GELQVIELNL NQNQISQISV KISCCPRLKI
LRLEENCLEL SMLPQSILSD SQICLLAVEG NLFEIKKLRE LEGYDKYMER FTATKKKFA
