LRC57_MOUSE
ID LRC57_MOUSE Reviewed; 239 AA.
AC Q9D1G5; Q9DC95;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Leucine-rich repeat-containing protein 57;
GN Name=Lrrc57;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8N9N7}; Lipid-
CC anchor {ECO:0000250|UniProtKB:Q8N9N7}.
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DR EMBL; AK003037; BAB22524.1; -; mRNA.
DR EMBL; AK003592; BAB22881.1; -; mRNA.
DR CCDS; CCDS16623.1; -.
DR AlphaFoldDB; Q9D1G5; -.
DR SMR; Q9D1G5; -.
DR STRING; 10090.ENSMUSP00000099555; -.
DR iPTMnet; Q9D1G5; -.
DR PhosphoSitePlus; Q9D1G5; -.
DR SwissPalm; Q9D1G5; -.
DR EPD; Q9D1G5; -.
DR MaxQB; Q9D1G5; -.
DR PaxDb; Q9D1G5; -.
DR PRIDE; Q9D1G5; -.
DR ProteomicsDB; 252510; -.
DR MGI; MGI:1913856; Lrrc57.
DR eggNOG; KOG0619; Eukaryota.
DR InParanoid; Q9D1G5; -.
DR PhylomeDB; Q9D1G5; -.
DR ChiTaRS; Lrrc57; mouse.
DR PRO; PR:Q9D1G5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9D1G5; protein.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR PROSITE; PS51450; LRR; 7.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Lipoprotein; Membrane; Myristate; Reference proteome;
KW Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8N9N7"
FT CHAIN 2..239
FT /note="Leucine-rich repeat-containing protein 57"
FT /id="PRO_0000227779"
FT REPEAT 39..60
FT /note="LRR 1"
FT REPEAT 63..85
FT /note="LRR 2"
FT REPEAT 86..107
FT /note="LRR 3"
FT REPEAT 109..130
FT /note="LRR 4"
FT REPEAT 132..153
FT /note="LRR 5"
FT REPEAT 154..175
FT /note="LRR 6"
FT REPEAT 177..197
FT /note="LRR 7"
FT REPEAT 202..222
FT /note="LRR 8"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9N7"
FT CONFLICT 209
FT /note="E -> G (in Ref. 1; BAB22524)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="F -> L (in Ref. 1; BAB22524)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 239 AA; 26760 MW; B74489961CB0ED70 CRC64;
MGNSALRAHV ETAQKTGVFQ LKDRGLTEFP SELQKLTSNL RTIDLSNNKI DSLPPLIIGK
FTLLKSLSLN NNKLTVLPDE LCNLKKLETL SLNNNHLREL PSTFGQLSAL KTLSLSGNQL
GALPPQLCCL RHLDVVDLSK NQIRSIPDTV GELQAIELNL NQNQISQLSV KISCCPRLKV
LRLEENCLEL SMLPQSILSD SQICLLAVEG NLFEIKKFRE LEGYDKYMER FTATKKKFA
