ID   LRC58_HUMAN             Reviewed;         371 AA.
AC   Q96CX6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Leucine-rich repeat-containing protein 58;
GN   Name=LRRC58;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH13757.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC013757; AAH13757.1; ALT_INIT; mRNA.
DR   CCDS; CCDS46892.1; -.
DR   RefSeq; NP_001093148.1; NM_001099678.1.
DR   AlphaFoldDB; Q96CX6; -.
DR   SMR; Q96CX6; -.
DR   BioGRID; 125468; 9.
DR   IntAct; Q96CX6; 6.
DR   MINT; Q96CX6; -.
DR   STRING; 9606.ENSP00000295628; -.
DR   GlyGen; Q96CX6; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q96CX6; -.
DR   PhosphoSitePlus; Q96CX6; -.
DR   BioMuta; LRRC58; -.
DR   DMDM; 162416229; -.
DR   EPD; Q96CX6; -.
DR   jPOST; Q96CX6; -.
DR   MassIVE; Q96CX6; -.
DR   MaxQB; Q96CX6; -.
DR   PaxDb; Q96CX6; -.
DR   PeptideAtlas; Q96CX6; -.
DR   PRIDE; Q96CX6; -.
DR   ProteomicsDB; 76240; -.
DR   Antibodypedia; 58235; 20 antibodies from 12 providers.
DR   DNASU; 116064; -.
DR   Ensembl; ENST00000295628.4; ENSP00000295628.3; ENSG00000163428.4.
DR   GeneID; 116064; -.
DR   KEGG; hsa:116064; -.
DR   MANE-Select; ENST00000295628.4; ENSP00000295628.3; NM_001099678.2; NP_001093148.1.
DR   UCSC; uc003edr.3; human.
DR   CTD; 116064; -.
DR   DisGeNET; 116064; -.
DR   GeneCards; LRRC58; -.
DR   HGNC; HGNC:26968; LRRC58.
DR   HPA; ENSG00000163428; Low tissue specificity.
DR   neXtProt; NX_Q96CX6; -.
DR   OpenTargets; ENSG00000163428; -.
DR   PharmGKB; PA142671517; -.
DR   VEuPathDB; HostDB:ENSG00000163428; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000156556; -.
DR   HOGENOM; CLU_000288_18_2_1; -.
DR   InParanoid; Q96CX6; -.
DR   OMA; CKGVYFD; -.
DR   OrthoDB; 892895at2759; -.
DR   PhylomeDB; Q96CX6; -.
DR   TreeFam; TF351911; -.
DR   PathwayCommons; Q96CX6; -.
DR   SignaLink; Q96CX6; -.
DR   BioGRID-ORCS; 116064; 14 hits in 1074 CRISPR screens.
DR   ChiTaRS; LRRC58; human.
DR   GenomeRNAi; 116064; -.
DR   Pharos; Q96CX6; Tdark.
DR   PRO; PR:Q96CX6; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q96CX6; protein.
DR   Bgee; ENSG00000163428; Expressed in upper arm skin and 195 other tissues.
DR   Genevisible; Q96CX6; HS.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 3.
DR   SMART; SM00369; LRR_TYP; 7.
DR   PROSITE; PS51450; LRR; 8.
PE   1: Evidence at protein level;
KW   Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..371
FT                   /note="Leucine-rich repeat-containing protein 58"
FT                   /id="PRO_0000312017"
FT   REPEAT          45..66
FT                   /note="LRR 1"
FT   REPEAT          69..91
FT                   /note="LRR 2"
FT   REPEAT          92..113
FT                   /note="LRR 3"
FT   REPEAT          121..143
FT                   /note="LRR 4"
FT   REPEAT          144..166
FT                   /note="LRR 5"
FT   REPEAT          167..189
FT                   /note="LRR 6"
FT   REPEAT          190..211
FT                   /note="LRR 7"
FT   REPEAT          213..234
FT                   /note="LRR 8"
FT   REPEAT          236..256
FT                   /note="LRR 9"
FT   REGION          340..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..355
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19690332"
SQ   SEQUENCE   371 AA;  40586 MW;  89C66EAD62CBE55C CRC64;
     MEEAGAAVVT AGEAELNWSR LSVSTETLES ELEARGEERR GAREALLRLL LPHNRLVSLP
     RALGSGFPHL QLLDVSGNAL TALGPELLAL RGLRTLLAKN NRLGGPSALP KGLAQSPLCR
     SLQVLNLSGN CFQEVPASLL ELRALQTLSL GGNQLQSIPA EIENLQSLEC LYLGGNFIKE
     IPPELGNLPS LNYLVLCDNK IQSIPPQLSQ LHSLRSLSLH NNLLTYLPRE ILNLIHLEEL
     SLRGNPLVVR FVRDLTYDPP TLLELAARTI KIRNISYTPY DLPGNLLRYL GSASNCPNPK
     CGGVYFDCCV RQIKFVDFCG KYRLPLMHYL CSPECSSPCS SASHSSTSQS ESDSEDEASV
     AARRMQKVLL G