LRC58_MOUSE
ID LRC58_MOUSE Reviewed; 366 AA.
AC Q3UGP9; B2RU81; Q8BX06;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Leucine-rich repeat-containing protein 58;
GN Name=Lrrc58;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK049274; BAC33650.1; -; mRNA.
DR EMBL; AK147818; BAE28158.1; -; mRNA.
DR EMBL; BC141007; AAI41008.1; -; mRNA.
DR CCDS; CCDS37340.1; -.
DR RefSeq; NP_796067.2; NM_177093.3.
DR AlphaFoldDB; Q3UGP9; -.
DR SMR; Q3UGP9; -.
DR BioGRID; 235824; 1.
DR STRING; 10090.ENSMUSP00000077779; -.
DR iPTMnet; Q3UGP9; -.
DR PhosphoSitePlus; Q3UGP9; -.
DR EPD; Q3UGP9; -.
DR MaxQB; Q3UGP9; -.
DR PaxDb; Q3UGP9; -.
DR PeptideAtlas; Q3UGP9; -.
DR PRIDE; Q3UGP9; -.
DR ProteomicsDB; 292356; -.
DR Antibodypedia; 58235; 20 antibodies from 12 providers.
DR DNASU; 320184; -.
DR Ensembl; ENSMUST00000078717; ENSMUSP00000077779; ENSMUSG00000034158.
DR GeneID; 320184; -.
DR KEGG; mmu:320184; -.
DR UCSC; uc007zek.1; mouse.
DR CTD; 116064; -.
DR MGI; MGI:2443542; Lrrc58.
DR VEuPathDB; HostDB:ENSMUSG00000034158; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000156556; -.
DR HOGENOM; CLU_000288_18_2_1; -.
DR InParanoid; Q3UGP9; -.
DR OMA; CKGVYFD; -.
DR OrthoDB; 892895at2759; -.
DR PhylomeDB; Q3UGP9; -.
DR TreeFam; TF351911; -.
DR BioGRID-ORCS; 320184; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Lrrc58; mouse.
DR PRO; PR:Q3UGP9; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q3UGP9; protein.
DR Bgee; ENSMUSG00000034158; Expressed in gonadal ridge and 251 other tissues.
DR Genevisible; Q3UGP9; MM.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 7.
DR PROSITE; PS51450; LRR; 8.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..366
FT /note="Leucine-rich repeat-containing protein 58"
FT /id="PRO_0000312018"
FT REPEAT 40..61
FT /note="LRR 1"
FT REPEAT 64..86
FT /note="LRR 2"
FT REPEAT 87..108
FT /note="LRR 3"
FT REPEAT 116..138
FT /note="LRR 4"
FT REPEAT 139..161
FT /note="LRR 5"
FT REPEAT 162..184
FT /note="LRR 6"
FT REPEAT 185..206
FT /note="LRR 7"
FT REPEAT 208..229
FT /note="LRR 8"
FT REPEAT 231..251
FT /note="LRR 9"
FT REGION 337..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96CX6"
FT CONFLICT 125
FT /note="N -> S (in Ref. 1; BAC33650)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 366 AA; 40139 MW; 32BFE6E94D30AA76 CRC64;
MEEAALGEAE LNWSRLSVSA EALESELEAR AEERRGAREA LLRLLLPYNR LTSLPRALGG
GFPHLQLLDV SGNSLTALGP ELLTLSGLRT LLARNNRLGG PGSLPKGLAQ SPLCRSLQVL
NLSGNCFQEL PASLLELRAL QTLSLGGNQL QSIPAEIENL RSLECLYLGG NFIKEIPPEL
ANLPSLNYLV LCDNKIQSVP PQLSQLHSLR SLSLHNNLLT YLPREILNLI HLEELSLRGN
PLVVRFVRDL TYDPPTLLEL AARTIKIRSI SYTPYDLPGN LLRYLGSASN CPNPKCGGVY
FDCCVRQIKF VDFCGKYRLP LMHYLCSPEC SSPCSSASHS STSQSESDSE DEASVAAHRM
QKVLLG
