LRC59_CHICK
ID LRC59_CHICK Reviewed; 339 AA.
AC Q5F334;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Leucine-rich repeat-containing protein 59;
GN Name=LRRC59; ORFNames=RCJMB04_38i14;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Required for nuclear import of FGF1. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SGO1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250}; Single-pass
CC type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
CC {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC Nucleus envelope {ECO:0000250}. Note=Localization in the nuclear
CC envelope depends upon the nuclear import machinery. {ECO:0000250}.
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DR EMBL; AJ851816; CAH65450.1; -; mRNA.
DR RefSeq; NP_001012588.1; NM_001012570.1.
DR AlphaFoldDB; Q5F334; -.
DR SMR; Q5F334; -.
DR STRING; 9031.ENSGALP00000012427; -.
DR PaxDb; Q5F334; -.
DR GeneID; 422103; -.
DR KEGG; gga:422103; -.
DR CTD; 55379; -.
DR VEuPathDB; HostDB:geneid_422103; -.
DR eggNOG; KOG0473; Eukaryota.
DR InParanoid; Q5F334; -.
DR OrthoDB; 1388480at2759; -.
DR PhylomeDB; Q5F334; -.
DR PRO; PR:Q5F334; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 3.
PE 2: Evidence at transcript level;
KW Coiled coil; Endoplasmic reticulum; Leucine-rich repeat; Membrane;
KW Microsome; Nucleus; Reference proteome; Repeat; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..339
FT /note="Leucine-rich repeat-containing protein 59"
FT /id="PRO_0000235162"
FT TOPO_DOM 1..282
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..339
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 10..31
FT /note="LRR 1"
FT REPEAT 40..61
FT /note="LRR 2"
FT REPEAT 63..84
FT /note="LRR 3"
FT REPEAT 86..107
FT /note="LRR 4"
FT REGION 186..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 181..254
FT /evidence="ECO:0000255"
FT COMPBIAS 186..258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 339 AA; 38666 MW; 897553DFFFD1CE81 CRC64;
MARGGGKSGS LKDKLDGNEL DLSLCGLSEV PVRELAALPK ATVLDLSCNS LVSLPSDFCS
LTHLVKLDLS KNRLQQLPVD FGRLVSLQHL DLLNNRLVTL PVSFAQLKLS LHHSPVEILS
RLLGTPSSLL VFHSFHSWEN QNLKWLDLKD NPLDPVLAKV AGDCLDEKQC KQAAVRVLQH
MKVIQSEQDR ERQRKLQAER EMEKKREAEQ RAREAQEREL RKREKAEEKE RRRREYDAQR
AAKQEMEKKT KKETVQTRKL ASSSRPPQPA RHKHSWSRSV LRALLLVLLC ILCTLAVCKL
TELQHQPLCV SVNTLYEDVV AAVQNHKTLQ NMLQQNSQQ
