ID   LRC59_DANRE             Reviewed;         314 AA.
AC   Q6NWG1;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Leucine-rich repeat-containing protein 59;
GN   Name=lrrc59; ORFNames=zgc:85752;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for nuclear import of FGF1. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SGO1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250}; Single-pass
CC       type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
CC       {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC       Nucleus envelope {ECO:0000250}. Note=Localization in the nuclear
CC       envelope depends upon the nuclear import machinery. {ECO:0000250}.
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DR   EMBL; BC067603; AAH67603.1; -; mRNA.
DR   RefSeq; NP_998097.1; NM_212932.1.
DR   AlphaFoldDB; Q6NWG1; -.
DR   SMR; Q6NWG1; -.
DR   STRING; 7955.ENSDARP00000096361; -.
DR   PaxDb; Q6NWG1; -.
DR   GeneID; 405868; -.
DR   KEGG; dre:405868; -.
DR   CTD; 55379; -.
DR   ZFIN; ZDB-GENE-040426-2547; lrrc59.
DR   eggNOG; KOG0473; Eukaryota.
DR   InParanoid; Q6NWG1; -.
DR   OrthoDB; 1388480at2759; -.
DR   PRO; PR:Q6NWG1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endoplasmic reticulum; Leucine-rich repeat; Membrane;
KW   Microsome; Nucleus; Reference proteome; Repeat; Signal-anchor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Leucine-rich repeat-containing protein 59"
FT                   /id="PRO_0000235163"
FT   TOPO_DOM        1..247
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..314
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REPEAT          14..35
FT                   /note="LRR 1"
FT   REPEAT          38..60
FT                   /note="LRR 2"
FT   REPEAT          61..82
FT                   /note="LRR 3"
FT   REPEAT          84..106
FT                   /note="LRR 4"
FT   REPEAT          107..126
FT                   /note="LRR 5"
FT   REGION          165..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          146..216
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        212..229
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  35904 MW;  A42605C6CA549EBB CRC64;
     MNKGKIENIK DKIDGNELDL SLSNLTEVPV KELAAFPKAT FLDLSCNNLI TLTPEFCSLT
     HLIKIDLNKN QLVCLPEEIG QLVNLQHLDL YNNKLKMLPI GFSQLKSLKW LDLKDNPLEP
     TLAKAAGDCL DEKQCRQCAS RVLQHMKVLQ EEAEKELERR LLKEREQEKK KEAKQREKEA
     REKEAQKKKK AEEKERKRKE YQAQVAAVAA QEQQKKKKEE KKKKAAQNQG KKAAPESVPK
     AKRSICSLFF SLLLKLVLLL VIGVSSVVAV CQLTELRKEA FCIPLNVHFE ETVRWAQGLD
     VVQQVIQKMS DLRT