ID   LRC59_XENLA             Reviewed;         307 AA.
AC   Q8AVS8;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Leucine-rich repeat-containing protein 59;
GN   Name=lrrc59;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for nuclear import of FGF1. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SGO1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250}; Single-pass
CC       type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
CC       {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC       Nucleus envelope {ECO:0000250}. Note=Localization in the nuclear
CC       envelope depends upon the nuclear import machinery. {ECO:0000250}.
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DR   EMBL; BC041285; AAH41285.1; -; mRNA.
DR   RefSeq; NP_001079394.1; NM_001085925.1.
DR   AlphaFoldDB; Q8AVS8; -.
DR   SMR; Q8AVS8; -.
DR   DNASU; 379081; -.
DR   GeneID; 379081; -.
DR   KEGG; xla:379081; -.
DR   CTD; 379081; -.
DR   Xenbase; XB-GENE-963192; lrrc59.S.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 379081; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endoplasmic reticulum; Leucine-rich repeat; Membrane;
KW   Microsome; Nucleus; Reference proteome; Repeat; Signal-anchor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..307
FT                   /note="Leucine-rich repeat-containing protein 59"
FT                   /id="PRO_0000235164"
FT   TOPO_DOM        1..247
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..307
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REPEAT          10..31
FT                   /note="LRR 1"
FT   REPEAT          40..61
FT                   /note="LRR 2"
FT   REPEAT          63..84
FT                   /note="LRR 3"
FT   REPEAT          86..107
FT                   /note="LRR 4"
FT   REPEAT          109..131
FT                   /note="LRR 5"
FT   REGION          170..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          156..222
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        170..191
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..238
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  35431 MW;  4D950D6DA2D5914F CRC64;
     MARANGRSQN LRDKLDGNEL DLSLSDLSEV PVRDLVAIPK ATALDLSCNK LTTLPDDFCN
     LSHIVRLDLS KNQIVQLPSE FGRLMNLQHL DLLQNHLMSL PVSFAQLKSL KWLDLKDNPL
     KPDLAKVAGD CLDEKQCKEC AQRVLQYMKS VQSDHEIELQ RKLQLDKERK KKLEAKQRVK
     EEQEREMRKR KKQQQKERKR RDYNAMQEAE RALNSNKKAE EEPTENHKRM ATPKEKKLAQ
     RQSRLRKIAC ILLFGLLVVL LVVVACRFTD LKAINMCTSV NAIYKETLSA LHSNPVLERF
     LQDPSSQ