LRC59_XENTR
ID LRC59_XENTR Reviewed; 308 AA.
AC Q6NX28;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Leucine-rich repeat-containing protein 59;
GN Name=lrrc59;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for nuclear import of FGF1. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SGO1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250}; Single-pass
CC type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
CC {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC Nucleus envelope {ECO:0000250}. Note=Localization in the nuclear
CC envelope depends upon the nuclear import machinery. {ECO:0000250}.
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DR EMBL; BC067310; AAH67310.1; -; mRNA.
DR RefSeq; NP_001001205.1; NM_001001205.1.
DR RefSeq; XP_017953180.1; XM_018097691.1.
DR AlphaFoldDB; Q6NX28; -.
DR SMR; Q6NX28; -.
DR STRING; 8364.ENSXETP00000041998; -.
DR PaxDb; Q6NX28; -.
DR DNASU; 407863; -.
DR GeneID; 407863; -.
DR KEGG; xtr:407863; -.
DR CTD; 55379; -.
DR Xenbase; XB-GENE-963187; lrrc59.
DR eggNOG; KOG0473; Eukaryota.
DR HOGENOM; CLU_062247_1_0_1; -.
DR InParanoid; Q6NX28; -.
DR OMA; SWIREQE; -.
DR OrthoDB; 1388480at2759; -.
DR PhylomeDB; Q6NX28; -.
DR TreeFam; TF316929; -.
DR Proteomes; UP000008143; Chromosome 10.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000006835; Expressed in neurula embryo and 12 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 4.
PE 2: Evidence at transcript level;
KW Coiled coil; Endoplasmic reticulum; Leucine-rich repeat; Membrane;
KW Microsome; Nucleus; Reference proteome; Repeat; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..308
FT /note="Leucine-rich repeat-containing protein 59"
FT /id="PRO_0000235165"
FT TOPO_DOM 1..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..308
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 10..31
FT /note="LRR 1"
FT REPEAT 40..61
FT /note="LRR 2"
FT REPEAT 63..84
FT /note="LRR 3"
FT REPEAT 86..107
FT /note="LRR 4"
FT REPEAT 109..128
FT /note="LRR 5"
FT REGION 170..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 154..223
FT /evidence="ECO:0000255"
FT COMPBIAS 170..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 308 AA; 35350 MW; 1CBD8AC7ED242875 CRC64;
MARANGRSQN LRDKLDGNEL DLSLSDLSEV PVRDLVAIPK ATALDLSCNK LTSLPDDFCN
LSYIVRLDLS KNQIAQLPSE FGRLVNLQHL DLLQNRIVAL PVSFAQLKSL KWLDLKDNPL
KPALAKVAGD CLDEKQCKEC AQGVLQYMKS VQSDHERELQ RKLQLDKDRK QRLEAQQRVK
EEQDRELRKR MKQQQKERKR RDYNAMQEAQ KALNNNKKKA EEEPSENHKP VPTPKEKKLA
RRQSRLRKIA CILLFGLMVA LLGVVACRFT DLKTFEVCRS VNAVYKETLS ALHSNPVLER
FLQDPSSQ
