LRC61_HUMAN
ID LRC61_HUMAN Reviewed; 259 AA.
AC Q9BV99; B3KUW0; D3DWY8;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Leucine-rich repeat-containing protein 61;
GN Name=LRRC61;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-143.
RC TISSUE=Ovary;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9BV99; P46379-2: BAG6; NbExp=3; IntAct=EBI-2350424, EBI-10988864;
CC Q9BV99; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-2350424, EBI-747505;
CC Q9BV99; Q96A83-2: COL26A1; NbExp=3; IntAct=EBI-2350424, EBI-21553822;
CC Q9BV99; O14645: DNALI1; NbExp=3; IntAct=EBI-2350424, EBI-395638;
CC Q9BV99; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-2350424, EBI-743105;
CC Q9BV99; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-2350424, EBI-744099;
CC Q9BV99; Q8WU58: FAM222B; NbExp=3; IntAct=EBI-2350424, EBI-2807642;
CC Q9BV99; O14964: HGS; NbExp=3; IntAct=EBI-2350424, EBI-740220;
CC Q9BV99; Q9UMF0: ICAM5; NbExp=3; IntAct=EBI-2350424, EBI-6398041;
CC Q9BV99; O14901: KLF11; NbExp=3; IntAct=EBI-2350424, EBI-948266;
CC Q9BV99; Q13449: LSAMP; NbExp=3; IntAct=EBI-2350424, EBI-4314821;
CC Q9BV99; P28331-2: NDUFS1; NbExp=3; IntAct=EBI-2350424, EBI-6190702;
CC Q9BV99; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-2350424, EBI-2811583;
CC Q9BV99; Q16512: PKN1; NbExp=3; IntAct=EBI-2350424, EBI-602382;
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DR EMBL; AK098061; BAG53572.1; -; mRNA.
DR EMBL; AC005586; AAS00383.1; -; Genomic_DNA.
DR EMBL; CH471173; EAW54123.1; -; Genomic_DNA.
DR EMBL; CH471173; EAW54124.1; -; Genomic_DNA.
DR EMBL; CH471173; EAW54125.1; -; Genomic_DNA.
DR EMBL; BC001354; AAH01354.1; -; mRNA.
DR CCDS; CCDS5901.1; -.
DR RefSeq; NP_001136400.1; NM_001142928.1.
DR RefSeq; NP_076431.1; NM_023942.2.
DR RefSeq; XP_006716158.1; XM_006716095.2.
DR AlphaFoldDB; Q9BV99; -.
DR SMR; Q9BV99; -.
DR BioGRID; 122446; 89.
DR IntAct; Q9BV99; 16.
DR STRING; 9606.ENSP00000352642; -.
DR iPTMnet; Q9BV99; -.
DR PhosphoSitePlus; Q9BV99; -.
DR BioMuta; LRRC61; -.
DR DMDM; 74761282; -.
DR MassIVE; Q9BV99; -.
DR MaxQB; Q9BV99; -.
DR PaxDb; Q9BV99; -.
DR PeptideAtlas; Q9BV99; -.
DR PRIDE; Q9BV99; -.
DR ProteomicsDB; 79188; -.
DR Antibodypedia; 18601; 58 antibodies from 16 providers.
DR DNASU; 65999; -.
DR Ensembl; ENST00000323078.7; ENSP00000339047.6; ENSG00000127399.15.
DR Ensembl; ENST00000359623.9; ENSP00000352642.4; ENSG00000127399.15.
DR Ensembl; ENST00000493307.1; ENSP00000420560.1; ENSG00000127399.15.
DR GeneID; 65999; -.
DR KEGG; hsa:65999; -.
DR MANE-Select; ENST00000359623.9; ENSP00000352642.4; NM_001142928.2; NP_001136400.1.
DR UCSC; uc003wgw.4; human.
DR CTD; 65999; -.
DR DisGeNET; 65999; -.
DR GeneCards; LRRC61; -.
DR HGNC; HGNC:21704; LRRC61.
DR HPA; ENSG00000127399; Low tissue specificity.
DR neXtProt; NX_Q9BV99; -.
DR OpenTargets; ENSG00000127399; -.
DR PharmGKB; PA143485530; -.
DR VEuPathDB; HostDB:ENSG00000127399; -.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00390000006479; -.
DR HOGENOM; CLU_1073482_0_0_1; -.
DR InParanoid; Q9BV99; -.
DR OMA; YWESWPT; -.
DR OrthoDB; 1411446at2759; -.
DR PhylomeDB; Q9BV99; -.
DR TreeFam; TF329333; -.
DR PathwayCommons; Q9BV99; -.
DR SignaLink; Q9BV99; -.
DR BioGRID-ORCS; 65999; 5 hits in 1072 CRISPR screens.
DR ChiTaRS; LRRC61; human.
DR GenomeRNAi; 65999; -.
DR Pharos; Q9BV99; Tdark.
DR PRO; PR:Q9BV99; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9BV99; protein.
DR Bgee; ENSG00000127399; Expressed in right uterine tube and 150 other tissues.
DR ExpressionAtlas; Q9BV99; baseline and differential.
DR Genevisible; Q9BV99; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR PROSITE; PS51450; LRR; 3.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..259
FT /note="Leucine-rich repeat-containing protein 61"
FT /id="PRO_0000236796"
FT REPEAT 32..53
FT /note="LRR 1"
FT REPEAT 54..75
FT /note="LRR 2"
FT REPEAT 76..97
FT /note="LRR 3"
FT REPEAT 98..119
FT /note="LRR 4"
FT DOMAIN 138..178
FT /note="LRRCT"
FT VARIANT 143
FT /note="N -> S (in dbSNP:rs3735169)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_051123"
SQ SEQUENCE 259 AA; 28014 MW; 7B63B0DFE743847A CRC64;
MDPPAEKPGE AGGLQITPQL LKSRTGEFSL ESILLLKLRG LGLADLGCLG ECLGLEWLDL
SGNALTHLGP LASLRQLAVL NVSNNRLTGL EPLATCENLQ SLNAAGNLLA TPGQLQCLAG
LPCLEYLRLR DPLARLSNPL CANPSYWAAV RELLPGLKVI DGERVIGRGS EFYQLCRDLD
SSLRPSSSPG PRATEAQPWV EPGYWESWPS RSSSILEEAC RQFQDTLQEC WDLDRQASDS
LAQAEQVLSS AGPTSSFVF
