LRC61_MOUSE
ID LRC61_MOUSE Reviewed; 259 AA.
AC Q8R2R5; Q3TB45; Q3UPT0;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=Leucine-rich repeat-containing protein 61;
GN Name=Lrrc61;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Diencephalon, and Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK136901; BAE23163.1; -; mRNA.
DR EMBL; AK143222; BAE25315.1; -; mRNA.
DR EMBL; AK171463; BAE42469.1; -; mRNA.
DR EMBL; BC027309; AAH27309.1; -; mRNA.
DR CCDS; CCDS39478.1; -.
DR RefSeq; NP_001103630.1; NM_001110160.1.
DR RefSeq; NP_808404.2; NM_177736.3.
DR RefSeq; XP_006506135.1; XM_006506072.2.
DR RefSeq; XP_006506136.1; XM_006506073.2.
DR RefSeq; XP_006506137.1; XM_006506074.2.
DR RefSeq; XP_006506138.1; XM_006506075.2.
DR RefSeq; XP_006506139.1; XM_006506076.2.
DR AlphaFoldDB; Q8R2R5; -.
DR SMR; Q8R2R5; -.
DR STRING; 10090.ENSMUSP00000110192; -.
DR PhosphoSitePlus; Q8R2R5; -.
DR MaxQB; Q8R2R5; -.
DR PaxDb; Q8R2R5; -.
DR PRIDE; Q8R2R5; -.
DR ProteomicsDB; 290159; -.
DR DNASU; 243371; -.
DR GeneID; 243371; -.
DR KEGG; mmu:243371; -.
DR UCSC; uc009buq.2; mouse.
DR CTD; 65999; -.
DR MGI; MGI:2652848; Lrrc61.
DR eggNOG; KOG0531; Eukaryota.
DR InParanoid; Q8R2R5; -.
DR OrthoDB; 1411446at2759; -.
DR PhylomeDB; Q8R2R5; -.
DR TreeFam; TF329333; -.
DR BioGRID-ORCS; 243371; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Lrrc61; mouse.
DR PRO; PR:Q8R2R5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8R2R5; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PROSITE; PS51450; LRR; 3.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..259
FT /note="Leucine-rich repeat-containing protein 61"
FT /id="PRO_0000236797"
FT REPEAT 54..75
FT /note="LRR 1"
FT REPEAT 76..97
FT /note="LRR 2"
FT REPEAT 98..119
FT /note="LRR 3"
FT DOMAIN 138..178
FT /note="LRRCT"
FT CONFLICT 47
FT /note="G -> V (in Ref. 1; BAE42469)"
FT /evidence="ECO:0000305"
FT CONFLICT 151
FT /note="R -> Q (in Ref. 1; BAE23163/BAE25315/BAE42469)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 259 AA; 27964 MW; B62B77E25F906FA1 CRC64;
MEPPGEKPGE AEALSITPQL LKSHSGEFAL DSILLLKLRG LGVVDLGCLG ECLNLEWLDL
SGNALTHLGP LASLRQLAVL NVSNNRLTGL EPLAACENLQ SLNAAGNLLT TPGQLQCLAG
LQALEHLRLR DPLARLSNPL CANASYWAVV RELLPGLKVI DGERVSGRGS ELYQLCRDLD
SSLRSGSSPG PRAIEAQPWV EPGYWESWPI RSSSILEEAC RQFQDTLQEC LDLDRQASDS
LAQAQQALSP AETTSSFVF
