LRC63_HUMAN
ID LRC63_HUMAN Reviewed; 580 AA.
AC Q05C16; Q5TBN0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Leucine-rich repeat-containing protein 63;
GN Name=LRRC63;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-506.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH30276.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AL137141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL139801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC030276; AAH30276.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001269389.1; NM_001282460.1.
DR AlphaFoldDB; Q05C16; -.
DR SMR; Q05C16; -.
DR BioGRID; 128644; 1.
DR IntAct; Q05C16; 1.
DR STRING; 9606.ENSP00000469337; -.
DR GlyGen; Q05C16; 2 sites.
DR iPTMnet; Q05C16; -.
DR PhosphoSitePlus; Q05C16; -.
DR BioMuta; LRRC63; -.
DR DMDM; 190359060; -.
DR MassIVE; Q05C16; -.
DR PaxDb; Q05C16; -.
DR PeptideAtlas; Q05C16; -.
DR PRIDE; Q05C16; -.
DR DNASU; 220416; -.
DR Ensembl; ENST00000378805.7; ENSP00000368082.3; ENSG00000173988.13.
DR GeneID; 220416; -.
DR KEGG; hsa:220416; -.
DR UCSC; uc058wwl.1; human.
DR CTD; 220416; -.
DR DisGeNET; 220416; -.
DR GeneCards; LRRC63; -.
DR HGNC; HGNC:34296; LRRC63.
DR neXtProt; NX_Q05C16; -.
DR VEuPathDB; HostDB:ENSG00000173988; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_027651_0_0_1; -.
DR InParanoid; Q05C16; -.
DR PhylomeDB; Q05C16; -.
DR PathwayCommons; Q05C16; -.
DR SignaLink; Q05C16; -.
DR BioGRID-ORCS; 220416; 5 hits in 943 CRISPR screens.
DR ChiTaRS; LRRC63; human.
DR GenomeRNAi; 220416; -.
DR Pharos; Q05C16; Tdark.
DR PRO; PR:Q05C16; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q05C16; protein.
DR Bgee; ENSG00000173988; Expressed in C1 segment of cervical spinal cord and 86 other tissues.
DR ExpressionAtlas; Q05C16; baseline and differential.
DR Genevisible; Q05C16; HS.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..580
FT /note="Leucine-rich repeat-containing protein 63"
FT /id="PRO_0000320628"
FT REPEAT 323..343
FT /note="LRR 1"
FT REPEAT 344..367
FT /note="LRR 2"
FT REPEAT 368..390
FT /note="LRR 3"
FT REPEAT 392..413
FT /note="LRR 4"
FT REPEAT 414..436
FT /note="LRR 5"
FT REPEAT 437..459
FT /note="LRR 6"
FT REPEAT 460..486
FT /note="LRR 7"
FT REPEAT 487..510
FT /note="LRR 8"
FT VARIANT 137
FT /note="M -> V (in dbSNP:rs7338697)"
FT /id="VAR_039236"
FT VARIANT 206
FT /note="M -> V (in dbSNP:rs6561303)"
FT /id="VAR_039237"
FT VARIANT 281
FT /note="K -> R (in dbSNP:rs12865423)"
FT /id="VAR_039238"
FT VARIANT 282
FT /note="T -> A (in dbSNP:rs12865424)"
FT /id="VAR_039239"
SQ SEQUENCE 580 AA; 66309 MW; EB954B85506605F4 CRC64;
MQKPPLLLRR PLPPKFTKLS LHEKKTHTAK TGKIESLHVA FTEDETTSIK MDRTRFPDVL
RNQSLTPINI QNIFLDHCVQ ERVTAISSPQ KSTKHVREQI PDTATGSIFF PHCNSASTRI
FGKQTNKMES SRKFKTMKDV YTEKRLENIL ILSSKFSKPK STPGSVIAQK LEKMHPKHQP
LPESPGYTYQ HISRDLSATV PSPPPMTVSM KPEGQWPEHF KSTATLTLRV TEFPGFVSLP
TPVLPRKPHR QSVIETLVTE NGNIESVPKQ IPPRPPEGLT KTEKIESEIH VVRGEGFKTV
AATRYETITA MTNLAIVNCQ VYGRNALNLK GFFILNCPDL TPLAFQLIYL NLSFNDLHYF
PTEILCLKNL QILKLRNNPI KEIPSEIQQL EFLRIFTIAF NLITVLPIGL FSLSYLEELD
VSYNELTFIP NEIQKLRSLE KLTVDGNELS FFPHGILKLN LTKIQFENNF THPCFWRDNY
LNNPQQLTQI ISLFIVQNKL HKFYDKIPVE VQKLLKWGAQ FLTELAPLSI YSSRKAITEG
YIAVELPKFE ESKNITEGLL TQKRYEEVMV KCINATTVTS
