LRC63_MOUSE
ID LRC63_MOUSE Reviewed; 637 AA.
AC A6H694; Q9D5X5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Leucine-rich repeat-containing protein 63;
GN Name=Lrrc63;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-637.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB29582.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC145796; AAI45797.1; -; mRNA.
DR EMBL; AK014850; BAB29582.1; ALT_INIT; mRNA.
DR RefSeq; NP_081857.1; NM_027581.1.
DR AlphaFoldDB; A6H694; -.
DR SMR; A6H694; -.
DR STRING; 10090.ENSMUSP00000022574; -.
DR iPTMnet; A6H694; -.
DR PhosphoSitePlus; A6H694; -.
DR PaxDb; A6H694; -.
DR PRIDE; A6H694; -.
DR ProteomicsDB; 292030; -.
DR GeneID; 70859; -.
DR KEGG; mmu:70859; -.
DR CTD; 220416; -.
DR MGI; MGI:1918109; Lrrc63.
DR eggNOG; KOG0619; Eukaryota.
DR InParanoid; A6H694; -.
DR OrthoDB; 1295759at2759; -.
DR PhylomeDB; A6H694; -.
DR BioGRID-ORCS; 70859; 6 hits in 71 CRISPR screens.
DR ChiTaRS; Lrrc63; mouse.
DR PRO; PR:A6H694; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; A6H694; protein.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..637
FT /note="Leucine-rich repeat-containing protein 63"
FT /id="PRO_0000320629"
FT REPEAT 388..411
FT /note="LRR 1"
FT REPEAT 412..434
FT /note="LRR 2"
FT REPEAT 436..457
FT /note="LRR 3"
FT REPEAT 459..480
FT /note="LRR 4"
FT REPEAT 481..503
FT /note="LRR 5"
FT REPEAT 504..530
FT /note="LRR 6"
FT REPEAT 531..555
FT /note="LRR 7"
FT REGION 220..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 290..294
FT /note="AAAAA -> TTTTT (in Ref. 2; BAB29582)"
FT /evidence="ECO:0000305"
FT CONFLICT 302..303
FT /note="AA -> TAV (in Ref. 2; BAB29582)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 637 AA; 71451 MW; 06990F21BED883DF CRC64;
MKKSIYRSLK TQQHPLLLRR PLPPKLPKVP LLKKKVRIVH TVKAREPKEE TYGKFDPDES
AFVKMDQNVS QSQRPTSTQT ICLDYDHKAL ERVVNIFPHQ HRVRRFHWKV PKSTAGSMFI
PRCLSASSRI FKNTLSQMKK RAKKSSKKEV KEDGYLTKKT FNTLVLSKEF SKPSPTSYSR
FIASKFKPLG TQFHPAPKIS GYSQELPLLR DVKRAALSPV PSTSSVIPEP QWSERTHPSA
APSKVVLNTG SLPPARSLPT PVLPRKPLRQ AMIENAAAAA AAAAAAAAAA AAAATTTTTT
TAATTTAAVS GKTEAHKPPE TVQRTTRTIG PDAHVLRGEG FKAVAATRSE TVLALTTLAI
INCQIYGRNA LNLKGFFLAN CPDLTPVAFQ LVYLNLSFND LNQFPIEILY LQNLQVLKLR
NNPIKEIPSE IHLLTYLRIF SIAFNYITKL PDGLFCLNYL EELDVSYNEI ENISNEIQKL
RSLEKLIVDG NPITSFPPGI LKLNLIKLQI ENTFTCSQFW LESSWNDPQQ LTQICSLFLV
KNKLLDYIPD AVRKSLKSTS ECDWCHGPKF GEGFRIIRSC DIFGVSHVPI MFHVCSSTCY
RDIRETSFVL EGFPSRRIAL HMDWVKESKV SNVSFYL
