LRC66_HUMAN
ID LRC66_HUMAN Reviewed; 880 AA.
AC Q68CR7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Leucine-rich repeat-containing protein 66;
GN Name=LRRC66;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon carcinoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; CR749811; CAH18671.1; -; mRNA.
DR CCDS; CCDS43229.1; -.
DR RefSeq; NP_001019782.1; NM_001024611.2.
DR AlphaFoldDB; Q68CR7; -.
DR SMR; Q68CR7; -.
DR BioGRID; 130975; 3.
DR IntAct; Q68CR7; 2.
DR STRING; 9606.ENSP00000341944; -.
DR GlyGen; Q68CR7; 4 sites.
DR iPTMnet; Q68CR7; -.
DR PhosphoSitePlus; Q68CR7; -.
DR BioMuta; LRRC66; -.
DR DMDM; 74757322; -.
DR MassIVE; Q68CR7; -.
DR MaxQB; Q68CR7; -.
DR PaxDb; Q68CR7; -.
DR PeptideAtlas; Q68CR7; -.
DR PRIDE; Q68CR7; -.
DR ProteomicsDB; 66026; -.
DR Antibodypedia; 3070; 57 antibodies from 15 providers.
DR DNASU; 339977; -.
DR Ensembl; ENST00000343457.3; ENSP00000341944.3; ENSG00000188993.4.
DR Ensembl; ENST00000682860.1; ENSP00000508002.1; ENSG00000188993.4.
DR GeneID; 339977; -.
DR KEGG; hsa:339977; -.
DR MANE-Select; ENST00000682860.1; ENSP00000508002.1; NM_001024611.3; NP_001019782.1.
DR UCSC; uc003gzi.4; human.
DR CTD; 339977; -.
DR GeneCards; LRRC66; -.
DR HGNC; HGNC:34299; LRRC66.
DR HPA; ENSG00000188993; Tissue enhanced (intestine, skeletal muscle).
DR neXtProt; NX_Q68CR7; -.
DR OpenTargets; ENSG00000188993; -.
DR PharmGKB; PA162394587; -.
DR VEuPathDB; HostDB:ENSG00000188993; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00390000014817; -.
DR HOGENOM; CLU_016612_0_0_1; -.
DR InParanoid; Q68CR7; -.
DR OMA; NAYSNEG; -.
DR OrthoDB; 364995at2759; -.
DR PhylomeDB; Q68CR7; -.
DR TreeFam; TF332577; -.
DR PathwayCommons; Q68CR7; -.
DR SignaLink; Q68CR7; -.
DR BioGRID-ORCS; 339977; 11 hits in 1065 CRISPR screens.
DR ChiTaRS; LRRC66; human.
DR GenomeRNAi; 339977; -.
DR Pharos; Q68CR7; Tdark.
DR PRO; PR:Q68CR7; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q68CR7; protein.
DR Bgee; ENSG00000188993; Expressed in jejunal mucosa and 98 other tissues.
DR Genevisible; Q68CR7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 5.
DR PROSITE; PS51450; LRR; 6.
PE 2: Evidence at transcript level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Phosphoprotein;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..880
FT /note="Leucine-rich repeat-containing protein 66"
FT /id="PRO_0000329433"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 86..107
FT /note="LRR 1"
FT REPEAT 110..130
FT /note="LRR 2"
FT REPEAT 149..171
FT /note="LRR 3"
FT REPEAT 172..193
FT /note="LRR 4"
FT REPEAT 196..217
FT /note="LRR 5"
FT REPEAT 220..241
FT /note="LRR 6"
FT REGION 319..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 855..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..880
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 723
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6TXF5"
FT MOD_RES 752
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K0B3"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 746
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 756
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 342
FT /note="G -> A (in dbSNP:rs17081784)"
FT /id="VAR_051124"
SQ SEQUENCE 880 AA; 97778 MW; 1C1C5C3CF4D33287 CRC64;
MKNLYFRVIT IVIGLYFTGI MTNASRKSNI LFNSECQWNE YILTNCSFTG KCDIPVDISQ
TAATVDVSFN FFRVLLQSHT KKEEWKIKHL DLSNNLISKI TLSPFAYLHA LEVLNLSNNA
IHSLSLDLLS PKSSWVKRHR SSFRNRFPLL KVLILQRNKL SDTPKGLWKL KSLQSLDLSF
NGILQIGWSD FHNCLQLENL CLKSNKIFKI PPQAFKDLKK LQVIDLSNNA LITILPMMII
ALEFPHLVVD LADNNWQCDD SVAVFQNFIS ESWRKKWNVI CNRSIGSEEA NGGTPQSRIS
RETRLPPIHL HRMKSLIRSK AERPQGGRHT GISTLGKKAK AGSGLRKKQR RLPRSVRSTR
DVQAAGKKED APQDLALAVC LSVFITFLVA FSLGAFTRPY VDRLWQKKCQ SKSPGLDNAY
SNEGFYDDME AAGHTPHPET HLRQVFPHLS LYENQTPFWV TQPHPHATVI PDRTLGRSRK
DPGSSQSPGQ CGDNTGAGSG NDGAVYSILQ RHPHAGNREL MSAAQDHIHR NDILGEWTYE
TVAQEEPLSA HSVGVSSVAG TSHAVSGSSR YDSNELDPSL SGEITASLCK MLTHAEAQRT
GDSKERGGTE QSLWDSQMEF SKERQVSSSI DLLSIQQPRL SGARAEEALS AHYSEVPYGD
PRDTGPSVFP PRWDSGLDVT PANKEPVQKS TPSDTCCELE SDCDSDEGSL FTLSSISSES
ARSKTEEAVP DEESLQDESS GASKDNVTAV DSLEENVTFQ TIPGKCKNQE DPFEKPLISA
PDSGMYKTHL ENASDTDRSE GLSPWPRSPG NSPLGDEFPG MFTYDYDTAL QSKAAEWHCS
LRDLEFSNVD VLQQTPPCSA EVPSDPDKAA FHERDSDILK
