LRC66_MOUSE
ID LRC66_MOUSE Reviewed; 872 AA.
AC Q8K0B3;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Leucine-rich repeat-containing protein 66;
GN Name=Lrrc66;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-752, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK051875; BAC34797.1; -; mRNA.
DR EMBL; BC031901; AAH31901.1; -; mRNA.
DR CCDS; CCDS19343.1; -.
DR RefSeq; NP_705796.1; NM_153568.1.
DR RefSeq; XP_006504015.1; XM_006503952.3.
DR AlphaFoldDB; Q8K0B3; -.
DR STRING; 10090.ENSMUSP00000084423; -.
DR GlyGen; Q8K0B3; 3 sites.
DR iPTMnet; Q8K0B3; -.
DR PhosphoSitePlus; Q8K0B3; -.
DR PaxDb; Q8K0B3; -.
DR PRIDE; Q8K0B3; -.
DR ProteomicsDB; 292358; -.
DR Antibodypedia; 3070; 57 antibodies from 15 providers.
DR DNASU; 231296; -.
DR Ensembl; ENSMUST00000087177; ENSMUSP00000084423; ENSMUSG00000067206.
DR GeneID; 231296; -.
DR KEGG; mmu:231296; -.
DR UCSC; uc008xta.1; mouse.
DR CTD; 339977; -.
DR MGI; MGI:2387634; Lrrc66.
DR VEuPathDB; HostDB:ENSMUSG00000067206; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00390000014817; -.
DR HOGENOM; CLU_016612_0_0_1; -.
DR InParanoid; Q8K0B3; -.
DR OMA; NAYSNEG; -.
DR OrthoDB; 364995at2759; -.
DR PhylomeDB; Q8K0B3; -.
DR TreeFam; TF332577; -.
DR BioGRID-ORCS; 231296; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8K0B3; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8K0B3; protein.
DR Bgee; ENSMUSG00000067206; Expressed in paneth cell and 29 other tissues.
DR ExpressionAtlas; Q8K0B3; baseline and differential.
DR Genevisible; Q8K0B3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 5.
PE 1: Evidence at protein level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Phosphoprotein;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..872
FT /note="Leucine-rich repeat-containing protein 66"
FT /id="PRO_0000329434"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 142..164
FT /note="LRR 1"
FT REPEAT 165..186
FT /note="LRR 2"
FT REPEAT 189..210
FT /note="LRR 3"
FT REPEAT 213..234
FT /note="LRR 4"
FT REPEAT 239..259
FT /note="LRR 5"
FT REGION 339..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 718
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6TXF5"
FT MOD_RES 752
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 472
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 872 AA; 97626 MW; B6CD8084071C1E2D CRC64;
MRDFYVRVTI LVTGLCFVET VTTPSRKSSV SFNPEYQRNG DLLVNWSSIR HVSQNTDAMD
RSFYFFRVLF QPHTQKERHI KPPDRTHHRI SKVTLDPLAH LHALEILNLS NKAIHYFSLD
QPLPPSSHQK RHGGHSHSRL PRLQVLILQR NQLSGTPKGL WKLKSLRSLD LSFNRIVHIG
LSDFHGCLQL ESIYLKSNKI CTIHPKAFKG LKKLQVVDLR SNALTTLVPI VTIALELPHL
ELGLADNQWQ CSESNVNFQN ITSSSWREIW KAICNMSVEN KRPNAETHQI RKSRDTHLLL
SPPSDLKSLI QSKAERPQAG MDMHLSALGK EAKDGYGDLR GMWPQSPVEL RDSQDEQVTD
RKDDKPPALE LAICLSVFIT FVVAFCLGAF ARPYIDRLRQ QRCSNKRPGS DNAYSNKGFH
GDIEGAQHME YQGTDLHQTT HHLHLSENQN PSWVAEPIPH SAVQSEQMLG SNGTDPGHQQ
SPEQLKDSNE SRSGDSIVLP SGPVAHLALH GLPNADAHKA ISPVQHHHDF LEEAHYDTVA
QEYSLIDDVM DRSSITGPLG TFPSSVESRR DDLHPSQPRD VVASFSKTLA HANTREAEGS
METGCPEPLG AMDSQMGSSE ERQVSNSIRE LATQQPSFQG VDAEERLSHV YSEVLHNDPP
SLRPRWGSGH YVIPATGEPV ERDAPFDPHY DLVTNYESDS DEGSLFTLSS EGSEDTRSLA
EEQASVENDG TSQPLPSRNL GEYKDSVTSA ESVEDLTSQR IPEKCEAQEA HLRNTLISGP
DSCVCETNQE NDSSSLDPEN RSTWPQLPGH KLSHHETLGT YGDIEPQSEA VDWHYSLRDL
ESPNVDSSPS PPYSDEDLSG PEDRARKRSK HW
