LRC66_RAT
ID LRC66_RAT Reviewed; 865 AA.
AC Q6TXF5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Leucine-rich repeat-containing protein 66;
DE AltName: Full=Liver regeneration-related protein LRRGT00044;
GN Name=Lrrc66;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RA Xu C.S., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J.,
RA Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B.,
RA Rahman S., Wang Q.N., Zhang J.B.;
RT "Liver regeneration after PH.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-714, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AY383699; AAQ96257.1; -; mRNA.
DR RefSeq; NP_001008763.1; NM_001008763.1.
DR RefSeq; XP_017454592.1; XM_017599103.1.
DR AlphaFoldDB; Q6TXF5; -.
DR STRING; 10116.ENSRNOP00000030477; -.
DR GlyGen; Q6TXF5; 3 sites.
DR iPTMnet; Q6TXF5; -.
DR PhosphoSitePlus; Q6TXF5; -.
DR PaxDb; Q6TXF5; -.
DR PRIDE; Q6TXF5; -.
DR GeneID; 289587; -.
DR KEGG; rno:289587; -.
DR UCSC; RGD:1306094; rat.
DR CTD; 339977; -.
DR RGD; 1306094; Lrrc66.
DR VEuPathDB; HostDB:ENSRNOG00000026585; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_016612_0_0_1; -.
DR InParanoid; Q6TXF5; -.
DR OMA; NAYSNEG; -.
DR OrthoDB; 364995at2759; -.
DR PhylomeDB; Q6TXF5; -.
DR TreeFam; TF332577; -.
DR PRO; PR:Q6TXF5; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000026585; Expressed in duodenum and 11 other tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Phosphoprotein;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..865
FT /note="Leucine-rich repeat-containing protein 66"
FT /id="PRO_0000329435"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 138..160
FT /note="LRR 1"
FT REPEAT 161..182
FT /note="LRR 2"
FT REPEAT 185..206
FT /note="LRR 3"
FT REPEAT 209..230
FT /note="LRR 4"
FT REPEAT 235..255
FT /note="LRR 5"
FT DOMAIN 728..759
FT /note="LRRNT"
FT REGION 463..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 714
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 748
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K0B3"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 248
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 787
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 865 AA; 95988 MW; 43BE96C199460485 CRC64;
MKDFYARVTV MVTGLCFVGT VTNPSRKSSL SLHQQDGDLL ANWSSTRHTS QKTDTVDRNS
YFFRVLFQPH TKERHTNHLD RTNHRLSKVT LSCLAHLRAL EMLNLGDDVI HSLCLDLSLP
SSSRQKRHRS RFRGRHPRLK VLLLQRNQLG PTPKGLWKLK PLCSLDLSFN RRVGIGLSGF
HGCLQLKSIY LKNNKILTIH PEAFKGLKKL QVVDLRSSAL TMLVPIVTIA LEWPNLELGL
ADNQWQCNES DANFQNIASV SWGEIWKAVC NTPVENEKPY VEASQIRISR DIHLPRSPSS
DLQSLIQSKA EKPRAGMDVH LSALEKKAQV GYGDLKGIWL QSPMELRDSQ GGPVTDRKDD
KPPDLALAVC LSVFITFVVA FCLGAFARPY IDRLRQQRCL NKRPGSENAY SNEGFHDDVE
AAQHVQHQGT DLCQTTHHLN LFENQDPSWG TEAIPHGAVL SERMLGSNGM DPSSQQSPGQ
FEDSGEARSG DGNMFPNGRV VHPAVHGLPS ADAQKPISPG QHHYDVPEES LYDTVAQEYS
LLDNAMDRSS VAGCLGTFPN SINSGRDELC PSQPRDVVAS FSKTLAHMST REAEESVERG
FPEPLGAMGS QIESSEERQV SNSIRELATQ QASFQEVDVE ERLAHVYSEA LYNDTPSHMP
RHSSGHDVAS ATEEAVQRDA SFDPHDDLVT NYESDSDEGS LFTLSSEGSQ DTRSLTEEQA
FVESGGDSQP LPSRNLGEYK DSVTSAESVE DITSQQTLEK REAQEAHLGN TLISGPDSCV
HETHLENDSS PLDPENVPTW TQPPDHKLAH HETLGTFVYG DIGPQSEAVD WLYSLRDLEF
PNIDSSPSPP CSDQDPSDPE EHDTK
