ID   LRC69_HUMAN             Reviewed;         347 AA.
AC   Q6ZNQ3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Leucine-rich repeat-containing protein 69;
GN   Name=LRRC69;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6ZNQ3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZNQ3-2; Sequence=VSP_033810;
CC   -!- SIMILARITY: Belongs to the LRRC69 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK130865; BAC85448.1; -; mRNA.
DR   EMBL; AC087439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471060; EAW91678.1; -; Genomic_DNA.
DR   CCDS; CCDS87619.1; -. [Q6ZNQ3-2]
DR   RefSeq; NP_001123362.1; NM_001129890.1. [Q6ZNQ3-1]
DR   AlphaFoldDB; Q6ZNQ3; -.
DR   SMR; Q6ZNQ3; -.
DR   BioGRID; 934878; 1.
DR   IntAct; Q6ZNQ3; 1.
DR   STRING; 9606.ENSP00000400803; -.
DR   iPTMnet; Q6ZNQ3; -.
DR   PhosphoSitePlus; Q6ZNQ3; -.
DR   BioMuta; LRRC69; -.
DR   DMDM; 189037067; -.
DR   MassIVE; Q6ZNQ3; -.
DR   PaxDb; Q6ZNQ3; -.
DR   PeptideAtlas; Q6ZNQ3; -.
DR   PRIDE; Q6ZNQ3; -.
DR   Antibodypedia; 63550; 69 antibodies from 15 providers.
DR   DNASU; 100130742; -.
DR   Ensembl; ENST00000343709.7; ENSP00000343221.3; ENSG00000214954.8. [Q6ZNQ3-2]
DR   Ensembl; ENST00000448384.2; ENSP00000400803.2; ENSG00000214954.8. [Q6ZNQ3-1]
DR   GeneID; 100130742; -.
DR   KEGG; hsa:100130742; -.
DR   MANE-Select; ENST00000448384.3; ENSP00000400803.2; NM_001129890.2; NP_001123362.1.
DR   UCSC; uc003yev.2; human. [Q6ZNQ3-1]
DR   CTD; 100130742; -.
DR   DisGeNET; 100130742; -.
DR   GeneCards; LRRC69; -.
DR   HGNC; HGNC:34303; LRRC69.
DR   HPA; ENSG00000214954; Tissue enhanced (testis).
DR   neXtProt; NX_Q6ZNQ3; -.
DR   PharmGKB; PA162394619; -.
DR   VEuPathDB; HostDB:ENSG00000214954; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000164066; -.
DR   HOGENOM; CLU_101819_0_0_1; -.
DR   InParanoid; Q6ZNQ3; -.
DR   OMA; TWLECVK; -.
DR   OrthoDB; 713821at2759; -.
DR   PhylomeDB; Q6ZNQ3; -.
DR   TreeFam; TF327010; -.
DR   PathwayCommons; Q6ZNQ3; -.
DR   SignaLink; Q6ZNQ3; -.
DR   BioGRID-ORCS; 100130742; 5 hits in 245 CRISPR screens.
DR   ChiTaRS; LRRC69; human.
DR   Pharos; Q6ZNQ3; Tdark.
DR   PRO; PR:Q6ZNQ3; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q6ZNQ3; protein.
DR   Bgee; ENSG00000214954; Expressed in calcaneal tendon and 91 other tissues.
DR   ExpressionAtlas; Q6ZNQ3; baseline and differential.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 3.
DR   SMART; SM00369; LRR_TYP; 7.
DR   PROSITE; PS51450; LRR; 8.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..347
FT                   /note="Leucine-rich repeat-containing protein 69"
FT                   /id="PRO_0000336072"
FT   REPEAT          38..60
FT                   /note="LRR 1"
FT   REPEAT          61..82
FT                   /note="LRR 2"
FT   REPEAT          84..105
FT                   /note="LRR 3"
FT   REPEAT          108..129
FT                   /note="LRR 4"
FT   REPEAT          131..153
FT                   /note="LRR 5"
FT   REPEAT          154..175
FT                   /note="LRR 6"
FT   REPEAT          177..199
FT                   /note="LRR 7"
FT   REPEAT          200..222
FT                   /note="LRR 8"
FT   VAR_SEQ         62..217
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_033810"
FT   VARIANT         64
FT                   /note="T -> I (in dbSNP:rs11785003)"
FT                   /id="VAR_043481"
SQ   SEQUENCE   347 AA;  39592 MW;  E17CCDA84C9AFC84 CRC64;
     MTERLLIKAL SGGKNTKIIT LNGKKMTKMP SALGKLPGLK TLVLQNNLIP KVCPELCNLT
     QLTTLNLGNN LLEEVPEEMK YLTSLKNLHL SGNRICRFAP GACDGLQNLI LLNLNNNHLT
     QLPQEVSRLK SLTYMSINYN QLASIPRELC FLENLVELQL NYNQLICIPE EIKFLKKLQK
     LLLARNNIGV LPEELCDLKK LRILDIAGNI IQIFPSGFQD LKLREFYCEG NPLFLQQPVI
     STQQENVWSL QEITSRFVMN QLAENNPFLM DDIERYPQVR SMISQGKTCA ICGQYFITVW
     LECVRFVPPP KDWKISKNLK LVPLQVLICS YKCFTQRDPN LFGIAQV