LRC69_MOUSE
ID LRC69_MOUSE Reviewed; 347 AA.
AC Q9D9Q0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Leucine-rich repeat-containing protein 69;
GN Name=Lrrc69;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SIMILARITY: Belongs to the LRRC69 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK006601; BAB24669.1; -; mRNA.
DR EMBL; AK161371; BAE36353.1; -; mRNA.
DR EMBL; AL772236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS38696.1; -.
DR RefSeq; NP_082775.1; NM_028499.2.
DR AlphaFoldDB; Q9D9Q0; -.
DR SMR; Q9D9Q0; -.
DR STRING; 10090.ENSMUSP00000023917; -.
DR PhosphoSitePlus; Q9D9Q0; -.
DR PaxDb; Q9D9Q0; -.
DR PRIDE; Q9D9Q0; -.
DR ProteomicsDB; 252511; -.
DR Antibodypedia; 63550; 69 antibodies from 15 providers.
DR Ensembl; ENSMUST00000023917; ENSMUSP00000023917; ENSMUSG00000023151.
DR Ensembl; ENSMUST00000108276; ENSMUSP00000103911; ENSMUSG00000023151.
DR GeneID; 73314; -.
DR KEGG; mmu:73314; -.
DR UCSC; uc008sba.1; mouse.
DR CTD; 100130742; -.
DR MGI; MGI:1920564; Lrrc69.
DR VEuPathDB; HostDB:ENSMUSG00000023151; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000164066; -.
DR HOGENOM; CLU_000288_18_15_1; -.
DR InParanoid; Q9D9Q0; -.
DR OMA; TWLECVK; -.
DR OrthoDB; 713821at2759; -.
DR PhylomeDB; Q9D9Q0; -.
DR TreeFam; TF327010; -.
DR BioGRID-ORCS; 73314; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Lrrc69; mouse.
DR PRO; PR:Q9D9Q0; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9D9Q0; protein.
DR Bgee; ENSMUSG00000023151; Expressed in seminiferous tubule of testis and 12 other tissues.
DR Genevisible; Q9D9Q0; MM.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 8.
DR PROSITE; PS51450; LRR; 9.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..347
FT /note="Leucine-rich repeat-containing protein 69"
FT /id="PRO_0000336073"
FT REPEAT 15..37
FT /note="LRR 1"
FT REPEAT 38..60
FT /note="LRR 2"
FT REPEAT 61..82
FT /note="LRR 3"
FT REPEAT 84..105
FT /note="LRR 4"
FT REPEAT 108..129
FT /note="LRR 5"
FT REPEAT 131..152
FT /note="LRR 6"
FT REPEAT 154..175
FT /note="LRR 7"
FT REPEAT 177..198
FT /note="LRR 8"
FT REPEAT 200..222
FT /note="LRR 9"
SQ SEQUENCE 347 AA; 40066 MW; 86BDCC40705C3E3E CRC64;
MAERLLVTAL KGGKNTKILT LNGKRITKMP STLEKLPNLK TLDLQNNSIS KVCPELRTLT
QLTLLNLGNN HLQEVPEEIK YLTSLKNLHL FGNRICRIAP GVFNGLHRLI MLNLNDNRLT
SLPQEIGRLR SLTYLSLNRN NLTVIPKELC SLEHLSELHL NYNQIVYIPE EIKFLKNLQQ
LFLVRNNIEE LPEEICHLEK LRVLDIAGNV IQIFPAGFQN LRLTEFYCEG NPLFLKRPFF
AVQPKDLWTL REIAARFVLS LLEENDPLIM NVIESYPEVK DKLSKAKKCS ICRKPFLTEW
LECVYFVAPS KNWKISRNLK LIPVQTSVCS YQCFDQRDPD VFGIAQE
