LRC71_HUMAN
ID LRC71_HUMAN Reviewed; 559 AA.
AC Q8N4P6; Q96M24;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Leucine-rich repeat-containing protein 71;
GN Name=LRRC71; Synonyms=C1orf92;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N4P6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N4P6-2; Sequence=VSP_024560, VSP_024561, VSP_024562;
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DR EMBL; AK057446; BAB71490.1; -; mRNA.
DR EMBL; AL356104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC033790; AAH33790.1; -; mRNA.
DR CCDS; CCDS44249.1; -. [Q8N4P6-1]
DR RefSeq; NP_653303.2; NM_144702.2. [Q8N4P6-1]
DR AlphaFoldDB; Q8N4P6; -.
DR SMR; Q8N4P6; -.
DR BioGRID; 127220; 2.
DR IntAct; Q8N4P6; 2.
DR STRING; 9606.ENSP00000336661; -.
DR iPTMnet; Q8N4P6; -.
DR PhosphoSitePlus; Q8N4P6; -.
DR BioMuta; LRRC71; -.
DR DMDM; 74759883; -.
DR MassIVE; Q8N4P6; -.
DR PaxDb; Q8N4P6; -.
DR PeptideAtlas; Q8N4P6; -.
DR PRIDE; Q8N4P6; -.
DR ProteomicsDB; 71955; -. [Q8N4P6-1]
DR ProteomicsDB; 71956; -. [Q8N4P6-2]
DR Antibodypedia; 34229; 31 antibodies from 16 providers.
DR DNASU; 149499; -.
DR Ensembl; ENST00000337428.8; ENSP00000336661.7; ENSG00000160838.14. [Q8N4P6-1]
DR GeneID; 149499; -.
DR KEGG; hsa:149499; -.
DR MANE-Select; ENST00000337428.8; ENSP00000336661.7; NM_144702.3; NP_653303.2.
DR UCSC; uc001fqm.3; human. [Q8N4P6-1]
DR CTD; 149499; -.
DR DisGeNET; 149499; -.
DR GeneCards; LRRC71; -.
DR HGNC; HGNC:26556; LRRC71.
DR HPA; ENSG00000160838; Tissue enhanced (choroid plexus, fallopian tube, testis).
DR neXtProt; NX_Q8N4P6; -.
DR OpenTargets; ENSG00000160838; -.
DR PharmGKB; PA142672476; -.
DR VEuPathDB; HostDB:ENSG00000160838; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00440000034367; -.
DR HOGENOM; CLU_035960_0_0_1; -.
DR InParanoid; Q8N4P6; -.
DR OMA; IDFAELC; -.
DR OrthoDB; 1139284at2759; -.
DR PhylomeDB; Q8N4P6; -.
DR TreeFam; TF329605; -.
DR PathwayCommons; Q8N4P6; -.
DR SignaLink; Q8N4P6; -.
DR BioGRID-ORCS; 149499; 19 hits in 1066 CRISPR screens.
DR ChiTaRS; LRRC71; human.
DR GenomeRNAi; 149499; -.
DR Pharos; Q8N4P6; Tdark.
DR PRO; PR:Q8N4P6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N4P6; protein.
DR Bgee; ENSG00000160838; Expressed in right uterine tube and 122 other tissues.
DR Genevisible; Q8N4P6; HS.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..559
FT /note="Leucine-rich repeat-containing protein 71"
FT /id="PRO_0000284542"
FT REPEAT 172..193
FT /note="LRR 1"
FT REPEAT 196..216
FT /note="LRR 2"
FT REPEAT 221..241
FT /note="LRR 3"
FT REPEAT 253..266
FT /note="LRR 4"
FT REPEAT 281..302
FT /note="LRR 5"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..215
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024560"
FT VAR_SEQ 443
FT /note="E -> EQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024561"
FT VAR_SEQ 522..559
FT /note="KNCFAPQCPAYAIIQELMLPRDPIKAKLREDEAMAFFP -> VSPFHSLLLK
FT QTLPLSAVILDSCCRQLLSPHFQGRKIASPHNVLRTP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024562"
FT VARIANT 483
FT /note="R -> H (in dbSNP:rs12119908)"
FT /id="VAR_031773"
FT VARIANT 503
FT /note="S -> A (in dbSNP:rs822431)"
FT /id="VAR_031774"
FT VARIANT 533
FT /note="A -> T (in dbSNP:rs11264585)"
FT /id="VAR_059593"
SQ SEQUENCE 559 AA; 61825 MW; E7FA2674403C21DC CRC64;
MSSEQSAPGA SPRAPRPGTQ KSSGAVTKKG ERAAKEKPAT VLPPVGEEEP KSPEEYQCSG
VLETDFAELC TRWGYTDFPK VVNRPRPHPP FVPSASLSEK ATLDDPRLSG SCSLNSLESK
YVFFRPTIQV ELEQEDSKSV KEIYIRGWKV EERILGVFSK CLPPLTQLQA INLWKVGLTD
KTLTTFIELL PLCSSTLRKV SLEGNPLPEQ SYHKLMALDS TIAHLSLRNN NIDDRGAQLL
GQALSTLHSC NRTLVSLNLG FNHIGDEGAG YIADGLRLNR SLLWLSLAHN RIQDKGALKL
AEVLRAFELT HTEVVERRRL LLEKGTQERS RSPSSSRHGD SKTDREKSQM VGISNSALVD
KTDKTQTMKT PKGLGKKKEK SWELAKKEEK LGSGQSPTQG TPKKEDATKA GKGKVTIPEQ
KPSRAKGIKI GSREKRSILL ESELVVEATE VVNPLLEPVE HRDGKVFMPG NKVLLHLNLI
RNRITEVGLE GFLATVQYQM QFSKAKSASK GPVGLLWLSL AKNCFAPQCP AYAIIQELML
PRDPIKAKLR EDEAMAFFP
