LRC71_MOUSE
ID LRC71_MOUSE Reviewed; 558 AA.
AC Q9D3W5; Q8C0S9;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Leucine-rich repeat-containing protein 71;
GN Name=Lrrc71;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC26688.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK016993; BAB30543.1; -; mRNA.
DR EMBL; AK029938; BAC26688.1; ALT_SEQ; mRNA.
DR CCDS; CCDS50946.1; -.
DR RefSeq; NP_083247.1; NM_028971.1.
DR AlphaFoldDB; Q9D3W5; -.
DR SMR; Q9D3W5; -.
DR BioGRID; 216790; 1.
DR STRING; 10090.ENSMUSP00000023846; -.
DR iPTMnet; Q9D3W5; -.
DR PhosphoSitePlus; Q9D3W5; -.
DR MaxQB; Q9D3W5; -.
DR PaxDb; Q9D3W5; -.
DR PRIDE; Q9D3W5; -.
DR ProteomicsDB; 252512; -.
DR Antibodypedia; 34229; 31 antibodies from 16 providers.
DR Ensembl; ENSMUST00000023846; ENSMUSP00000023846; ENSMUSG00000023084.
DR GeneID; 74485; -.
DR KEGG; mmu:74485; -.
DR UCSC; uc008psp.2; mouse.
DR CTD; 149499; -.
DR MGI; MGI:1921735; Lrrc71.
DR VEuPathDB; HostDB:ENSMUSG00000023084; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00440000034367; -.
DR HOGENOM; CLU_035960_0_0_1; -.
DR InParanoid; Q9D3W5; -.
DR OMA; IDFAELC; -.
DR OrthoDB; 1139284at2759; -.
DR PhylomeDB; Q9D3W5; -.
DR TreeFam; TF329605; -.
DR BioGRID-ORCS; 74485; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q9D3W5; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9D3W5; protein.
DR Bgee; ENSMUSG00000023084; Expressed in spermatocyte and 49 other tissues.
DR ExpressionAtlas; Q9D3W5; baseline and differential.
DR Genevisible; Q9D3W5; MM.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 3.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..558
FT /note="Leucine-rich repeat-containing protein 71"
FT /id="PRO_0000284543"
FT REPEAT 196..216
FT /note="LRR 1"
FT REPEAT 221..241
FT /note="LRR 2"
FT REPEAT 253..274
FT /note="LRR 3"
FT REPEAT 281..302
FT /note="LRR 4"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 558 AA; 61351 MW; F3487BC5359B0874 CRC64;
MSSEPSTTGT SPRTPRPGAQ KSSGAVTKKG DRAAKDKTAS TLPPVGEDEP KNPEEYQCTG
VLETDFAELC TRSGYVDFPK VVTRPRVQQS SVPSASTSEK PVLDDQRPSA SCSQSSLESK
YVFFRPTIQV ELEQEDSKAV KEIYIRGWKV EDRILGIFSK CLPSLSQLQA INLWKVGLTD
KTLTTFIALL PLCSSTLRKV SLEGNPIPEQ SFSKLMGLDS TIVHLSLRNN NINDHGAQLL
GQALSTLQNS NRTLVSLNLA FNHIGDVGAG YIADGLRLNR SLLWLSLAHN HIQDKGALKL
AEVLRPFELT HREVVERRRL LLVKGTQERS RSPSSSRYGD SKAEREKSQT LGISNVTLVD
KQEKMQSLKA PKTISKKKEK TGEVVKKEEK LGSGQSPTQG TPKKEDAAKA GKGKVTIPEQ
KMSKGKATKM GAKEKRSILL ESEQLVVEAT EMVNPLLEPV EHRDGKVFLP GNKVLLHLNL
LRNQITEVGL EGFLTAVQYQ VQVSKPKTSP KAPLGLLWLS LAKNCFDPQC PTHVMIQELM
LPRDPVKAKA REEEAAAT
