ID   LRC72_HUMAN             Reviewed;         287 AA.
AC   A6NJI9;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Leucine-rich repeat-containing protein 72;
GN   Name=LRRC72;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-76.
RA   Ebert L., Heil O., Hennig S., Neubert P., Partsch E., Peters M.,
RA   Radelof U., Schneider D., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BX102126; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR   EMBL; AC005014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX102126; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS56464.1; -.
DR   RefSeq; NP_001182209.1; NM_001195280.1.
DR   AlphaFoldDB; A6NJI9; -.
DR   SMR; A6NJI9; -.
DR   STRING; 9606.ENSP00000384971; -.
DR   iPTMnet; A6NJI9; -.
DR   PhosphoSitePlus; A6NJI9; -.
DR   BioMuta; LRRC72; -.
DR   MassIVE; A6NJI9; -.
DR   PaxDb; A6NJI9; -.
DR   PeptideAtlas; A6NJI9; -.
DR   PRIDE; A6NJI9; -.
DR   ProteomicsDB; 1339; -.
DR   Antibodypedia; 6444; 42 antibodies from 11 providers.
DR   DNASU; 100506049; -.
DR   Ensembl; ENST00000401542.3; ENSP00000384971.2; ENSG00000205858.10.
DR   GeneID; 100506049; -.
DR   KEGG; hsa:100506049; -.
DR   MANE-Select; ENST00000401542.3; ENSP00000384971.2; NM_001195280.2; NP_001182209.1.
DR   UCSC; uc022aaf.2; human.
DR   CTD; 100506049; -.
DR   GeneCards; LRRC72; -.
DR   HGNC; HGNC:42972; LRRC72.
DR   HPA; ENSG00000205858; Tissue enriched (testis).
DR   neXtProt; NX_A6NJI9; -.
DR   VEuPathDB; HostDB:ENSG00000205858; -.
DR   eggNOG; ENOG502S0DQ; Eukaryota.
DR   GeneTree; ENSGT00940000153289; -.
DR   HOGENOM; CLU_061027_4_0_1; -.
DR   InParanoid; A6NJI9; -.
DR   OMA; ITIFNHR; -.
DR   OrthoDB; 1447031at2759; -.
DR   PhylomeDB; A6NJI9; -.
DR   TreeFam; TF328384; -.
DR   PathwayCommons; A6NJI9; -.
DR   BioGRID-ORCS; 100506049; 9 hits in 1058 CRISPR screens.
DR   Pharos; A6NJI9; Tdark.
DR   PRO; PR:A6NJI9; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; A6NJI9; protein.
DR   Bgee; ENSG00000205858; Expressed in left testis and 20 other tissues.
DR   ExpressionAtlas; A6NJI9; baseline and differential.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR042655; LRC72.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR46759; PTHR46759; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..287
FT                   /note="Leucine-rich repeat-containing protein 72"
FT                   /id="PRO_0000346430"
FT   REPEAT          46..67
FT                   /note="LRR 1"
FT   REPEAT          68..89
FT                   /note="LRR 2"
FT   REPEAT          90..111
FT                   /note="LRR 3"
FT   REPEAT          112..133
FT                   /note="LRR 4"
FT   DOMAIN          147..185
FT                   /note="LRRCT"
SQ   SEQUENCE   287 AA;  33656 MW;  E6142E2FD3241815 CRC64;
     MSWDPNPVPR TLRCWRLRRA SETALQSSRR AVEDQLKICG HRRDADVFEL FLSKKELTEV
     IDLSRFKKLK YLWLHHNKLH GITFLTRNYC LTELYLNNNA IFEIEGLHYL PSLHILLLHH
     NELTNIDATV KELKGMLNLK ILSLYQNPLC QYNLYRLYII YHLPGVELLD RNQVTEKERR
     SMITIFNHKK AHIVQSIAFG GKVDASWDPK SPFKQKPAQR VPSDFAFANN VDKTVLDDPE
     DAVFVRSMKR SVMTLTSMNW DTVPTREERY LEEEGTETAQ MLTVTLR