LRC73_HUMAN
ID LRC73_HUMAN Reviewed; 316 AA.
AC Q5JTD7;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Leucine-rich repeat-containing protein 73;
GN Name=LRRC73; Synonyms=C6orf154;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5JTD7; Q6UWV6: ENPP7; NbExp=3; IntAct=EBI-12003882, EBI-12047821;
CC Q5JTD7; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-12003882, EBI-372506;
CC Q5JTD7; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-12003882, EBI-739832;
CC Q5JTD7; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12003882, EBI-741158;
CC Q5JTD7; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-12003882, EBI-79165;
CC Q5JTD7; Q9BUL9: RPP25; NbExp=3; IntAct=EBI-12003882, EBI-366570;
CC Q5JTD7; Q63HK5: TSHZ3; NbExp=3; IntAct=EBI-12003882, EBI-9053916;
CC Q5JTD7; Q6ZN55-2: ZNF574; NbExp=3; IntAct=EBI-12003882, EBI-17189720;
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DR EMBL; AL355802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC108661; AAI08662.1; -; mRNA.
DR CCDS; CCDS34456.1; -.
DR RefSeq; NP_001012992.1; NM_001012974.2.
DR RefSeq; NP_001258811.1; NM_001271882.1.
DR AlphaFoldDB; Q5JTD7; -.
DR SMR; Q5JTD7; -.
DR BioGRID; 128724; 34.
DR IntAct; Q5JTD7; 10.
DR MINT; Q5JTD7; -.
DR STRING; 9606.ENSP00000361518; -.
DR iPTMnet; Q5JTD7; -.
DR PhosphoSitePlus; Q5JTD7; -.
DR BioMuta; LRRC73; -.
DR DMDM; 74742140; -.
DR MassIVE; Q5JTD7; -.
DR PaxDb; Q5JTD7; -.
DR PeptideAtlas; Q5JTD7; -.
DR PRIDE; Q5JTD7; -.
DR ProteomicsDB; 63217; -.
DR Antibodypedia; 46004; 78 antibodies from 14 providers.
DR DNASU; 221424; -.
DR Ensembl; ENST00000372441.1; ENSP00000361518.1; ENSG00000204052.4.
DR GeneID; 221424; -.
DR KEGG; hsa:221424; -.
DR MANE-Select; ENST00000372441.2; ENSP00000361518.1; NM_001012974.4; NP_001012992.1.
DR UCSC; uc003ovk.3; human.
DR CTD; 221424; -.
DR GeneCards; LRRC73; -.
DR HGNC; HGNC:21375; LRRC73.
DR HPA; ENSG00000204052; Tissue enriched (testis).
DR neXtProt; NX_Q5JTD7; -.
DR OpenTargets; ENSG00000204052; -.
DR PharmGKB; PA134973511; -.
DR VEuPathDB; HostDB:ENSG00000204052; -.
DR eggNOG; ENOG502QSR8; Eukaryota.
DR GeneTree; ENSGT00390000003256; -.
DR HOGENOM; CLU_079918_0_0_1; -.
DR InParanoid; Q5JTD7; -.
DR OMA; WICQSNS; -.
DR OrthoDB; 1345365at2759; -.
DR PhylomeDB; Q5JTD7; -.
DR TreeFam; TF328343; -.
DR PathwayCommons; Q5JTD7; -.
DR SignaLink; Q5JTD7; -.
DR BioGRID-ORCS; 221424; 11 hits in 1058 CRISPR screens.
DR GenomeRNAi; 221424; -.
DR Pharos; Q5JTD7; Tdark.
DR PRO; PR:Q5JTD7; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5JTD7; protein.
DR Bgee; ENSG00000204052; Expressed in left testis and 111 other tissues.
DR Genevisible; Q5JTD7; HS.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR039984; LRRC73.
DR PANTHER; PTHR24111:SF2; PTHR24111:SF2; 2.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..316
FT /note="Leucine-rich repeat-containing protein 73"
FT /id="PRO_0000252159"
FT REPEAT 57..78
FT /note="LRR 1"
FT REPEAT 86..106
FT /note="LRR 2"
FT REPEAT 114..137
FT /note="LRR 3"
FT REPEAT 145..166
FT /note="LRR 4"
FT REPEAT 174..187
FT /note="LRR 5"
FT REPEAT 202..223
FT /note="LRR 6"
FT REPEAT 231..250
FT /note="LRR 7"
FT REGION 257..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 316 AA; 33409 MW; 014D6BD27350EDD2 CRC64;
MLPSSIQISG EPLSGAEVRD ICRGLRDNAV RLLSLRGCRL CDRDFGRICR ALAGATSLAQ
LNLNLGVVSS PSRIKQLAEA LRTNRSIQSL FLHGSPLTDA GLALLNPALA LHPALVALDL
GDCMLGDEAI NLICGLLPPD GAKSGLKELT LSANPGITPK GWSRLAIAVA HSSQVRVLNL
DYNPLGDHVA GMLAVAVASS RTLEVLDLEG TGLTNQSAQT LLDMVENYPT ALRSLVLAEN
SISPELQQQI CDLLSEGEEE EEVAGGAGDT QEWERGREPA AHQRGSSSWM CPSDPSSQMV
LMTSGLGDSL LAETEM
