LRCC1_HUMAN
ID LRCC1_HUMAN Reviewed; 1032 AA.
AC Q9C099; B4DYX6; B5RI11; Q8N768; Q96DK7; Q96N01;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Leucine-rich repeat and coiled-coil domain-containing protein 1;
DE AltName: Full=Centrosomal leucine-rich repeat and coiled-coil domain-containing protein;
GN Name=LRRCC1; Synonyms=CLERC, KIAA1764;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:347-355(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Gastric mucosa, Teratocarcinoma, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION, FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18728398; DOI=10.4161/cc.7.17.6591;
RA Muto Y., Yoshioka T., Kimura M., Matsunami M., Saya H., Okano Y.;
RT "An evolutionarily conserved leucine-rich repeat protein CLERC is a
RT centrosomal protein required for spindle pole integrity.";
RL Cell Cycle 7:2738-2748(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Required for the organization of the mitotic spindle.
CC Maintains the structural integrity of centrosomes during mitosis.
CC {ECO:0000269|PubMed:18728398}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000269|PubMed:18728398}.
CC Note=Associates with the centrosome throughout the cell cycle and
CC extensively accumulates during the mitotic phase.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9C099-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C099-2; Sequence=VSP_033868;
CC -!- SIMILARITY: Belongs to the LRRCC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH30701.3; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB21855.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB71115.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB71115.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown upstream of position 104 for unknown reason.; Evidence={ECO:0000305};
CC Sequence=BAB71626.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAG63888.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAG63888.1; Type=Miscellaneous discrepancy; Note=Readthrough of an in-frame TAG stop codon in position 34 translated as Gln.; Evidence={ECO:0000305};
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DR EMBL; AB051551; BAB21855.1; ALT_INIT; mRNA.
DR EMBL; AK302648; BAG63888.1; ALT_SEQ; mRNA.
DR EMBL; AK056185; BAB71115.1; ALT_SEQ; mRNA.
DR EMBL; AK057990; BAB71626.1; ALT_INIT; mRNA.
DR EMBL; AC011773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC083962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471068; EAW87121.1; -; Genomic_DNA.
DR EMBL; BC030701; AAH30701.3; ALT_SEQ; mRNA.
DR EMBL; BR000818; FAA00427.1; -; mRNA.
DR CCDS; CCDS43750.1; -. [Q9C099-1]
DR RefSeq; NP_208325.3; NM_033402.4. [Q9C099-1]
DR AlphaFoldDB; Q9C099; -.
DR SMR; Q9C099; -.
DR BioGRID; 124531; 30.
DR IntAct; Q9C099; 35.
DR MINT; Q9C099; -.
DR STRING; 9606.ENSP00000353538; -.
DR iPTMnet; Q9C099; -.
DR PhosphoSitePlus; Q9C099; -.
DR BioMuta; LRRCC1; -.
DR DMDM; 189028877; -.
DR EPD; Q9C099; -.
DR jPOST; Q9C099; -.
DR MassIVE; Q9C099; -.
DR MaxQB; Q9C099; -.
DR PaxDb; Q9C099; -.
DR PeptideAtlas; Q9C099; -.
DR PRIDE; Q9C099; -.
DR ProteomicsDB; 79973; -. [Q9C099-1]
DR ProteomicsDB; 79974; -. [Q9C099-2]
DR Antibodypedia; 2444; 14 antibodies from 10 providers.
DR DNASU; 85444; -.
DR Ensembl; ENST00000360375.8; ENSP00000353538.3; ENSG00000133739.16. [Q9C099-1]
DR Ensembl; ENST00000414626.2; ENSP00000394695.2; ENSG00000133739.16. [Q9C099-2]
DR GeneID; 85444; -.
DR KEGG; hsa:85444; -.
DR MANE-Select; ENST00000360375.8; ENSP00000353538.3; NM_033402.5; NP_208325.3.
DR UCSC; uc003ycw.4; human. [Q9C099-1]
DR CTD; 85444; -.
DR DisGeNET; 85444; -.
DR GeneCards; LRRCC1; -.
DR HGNC; HGNC:29373; LRRCC1.
DR HPA; ENSG00000133739; Tissue enhanced (testis).
DR MIM; 617791; gene.
DR neXtProt; NX_Q9C099; -.
DR OpenTargets; ENSG00000133739; -.
DR PharmGKB; PA142671519; -.
DR VEuPathDB; HostDB:ENSG00000133739; -.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00940000157414; -.
DR HOGENOM; CLU_011297_1_0_1; -.
DR InParanoid; Q9C099; -.
DR OMA; RKMKQPY; -.
DR OrthoDB; 747731at2759; -.
DR PhylomeDB; Q9C099; -.
DR TreeFam; TF329470; -.
DR PathwayCommons; Q9C099; -.
DR SignaLink; Q9C099; -.
DR BioGRID-ORCS; 85444; 16 hits in 1080 CRISPR screens.
DR ChiTaRS; LRRCC1; human.
DR GenomeRNAi; 85444; -.
DR Pharos; Q9C099; Tdark.
DR PRO; PR:Q9C099; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9C099; protein.
DR Bgee; ENSG00000133739; Expressed in calcaneal tendon and 122 other tissues.
DR ExpressionAtlas; Q9C099; baseline and differential.
DR Genevisible; Q9C099; HS.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PROSITE; PS51450; LRR; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Leucine-rich repeat; Mitosis; Reference proteome; Repeat.
FT CHAIN 1..1032
FT /note="Leucine-rich repeat and coiled-coil domain-
FT containing protein 1"
FT /id="PRO_0000337081"
FT REPEAT 44..65
FT /note="LRR 1"
FT REPEAT 66..87
FT /note="LRR 2"
FT REPEAT 88..109
FT /note="LRR 3"
FT REPEAT 110..131
FT /note="LRR 4"
FT REPEAT 136..157
FT /note="LRR 5"
FT DOMAIN 175..218
FT /note="LRRCT"
FT REGION 316..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 421..647
FT /evidence="ECO:0000255"
FT COMPBIAS 317..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..34
FT /note="MEAAAAVVAAEAEVENEDGDSSCGDVCFMDKGLQ -> MLLKSIFIVYIFFY
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11214970"
FT /id="VSP_033868"
FT VARIANT 69
FT /note="H -> Q (in dbSNP:rs16913589)"
FT /id="VAR_043584"
FT VARIANT 210
FT /note="T -> A (in dbSNP:rs3736038)"
FT /id="VAR_043585"
FT VARIANT 613
FT /note="K -> N (in dbSNP:rs6985225)"
FT /id="VAR_043586"
FT CONFLICT 90
FT /note="C -> Y (in Ref. 1; BAB21855 and 2; BAG63888)"
FT /evidence="ECO:0000305"
FT CONFLICT 121
FT /note="I -> V (in Ref. 5; AAH30701)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="C -> Y (in Ref. 5; AAH30701)"
FT /evidence="ECO:0000305"
FT CONFLICT 483
FT /note="R -> G (in Ref. 2; BAG63888)"
FT /evidence="ECO:0000305"
FT CONFLICT 687
FT /note="S -> P (in Ref. 2; BAB71626)"
FT /evidence="ECO:0000305"
FT CONFLICT 799
FT /note="E -> K (in Ref. 2; BAG63888)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1032 AA; 119596 MW; 4DC916268FBB12AB CRC64;
MEAAAAVVAA EAEVENEDGD SSCGDVCFMD KGLQSISELS LDSTLHAVNL HCNNISKIEA
IDHIWNLQHL DLSSNQISRI EGLNTLTKLC TLNLSCNLIT KVEGLEELIN LTRLNVSYNH
IDDLSGLIPL HGIKHKLRYI DLHSNRIDSI HHLLQCMVGL HFLTNLILEK DGDDNPVCRL
PGYRAVILQT LPQLRILDCK NIFGEPVNLT EINSSQLQCL EGLLDNLVSS DSPLNISEDE
IIDRMPVITA PIDELVPLEQ FASTPSDAVL TSFMSVCQSS EPEKNNHEND LQNEIKLQKL
DDQILQLLNE TSNSIDNVLE KDPRPKRDTD ITSESDYGNR KECNRKVPRR SKIPYDAKTI
QTIKHHNKNY NSFVSCNRKM KPPYLKELYV SSSLANCPML QESEKPKTEI IKVDQSHSED
NTYQSLVEQL DQEREKRWRA EQAENKLMDY IDELHKHANE KEDIHSLALL TTDRLKEIIF
RERNSKGQLE VMVHKLQNEI KKLTVELMKA KDQQEDHLKH LRTLEKTLEK MERQKRQQQA
AQIRLIQEVE LKASAADREI YLLRTSLHRE REQAQQLHQL LALKEQEHRK ELETREFFTD
ADFQDALAKE IAKEEKKHEQ MIKEYQEKID VLSQQYMDLE NEFRIALTVE ARRFQDVKDG
FENVATELAK SKHALIWAQR KENESSSLIK DLTCMVKEQK TKLAEVSKLK QETAANLQNQ
INTLEILIED DKQKSIQIEL LKHEKVQLIS ELAAKESLIF GLRTERKVWG HELAQQGSSL
AQNRGKLEAQ IESLSRENEC LRKTNESDSD ALRIKCKIID DQTETIRKLK DCLQEKDEHI
KRLQEKITEI EKCTQEQLDE KSSQLDEVLE KLERHNERKE KLKQQLKGKE VELEEIRKAY
STLNRKWHDK GELLCHLETQ VKEVKEKFEN KEKKLKAERD KSIELQKNAM EKLHSMDDAF
KRQVDAIVEA HQAEIAQLAN EKQKCIDSAN LKVHQIEKEM RELLEETCKN KKTMEAKIKQ
LAFALNEIQQ DM
