LRCC1_MOUSE
ID LRCC1_MOUSE Reviewed; 1026 AA.
AC Q69ZB0; B2RS58; Q4FZD6; Q6P8L1; Q9CUE1; Q9DC06;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Leucine-rich repeat and coiled-coil domain-containing protein 1;
GN Name=Lrrcc1; Synonyms=Kiaa1764;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryonic tail;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-870 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Lung, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-1012 (ISOFORM 2).
RC TISSUE=Brain, Eye, and Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for the organization of the mitotic spindle.
CC Maintains the structural integrity of centrosomes during mitosis (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole. Note=Associates with the centrosome
CC throughout the cell cycle and extensively accumulates during the
CC mitotic phase. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q69ZB0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q69ZB0-2; Sequence=VSP_033869;
CC Name=3;
CC IsoId=Q69ZB0-3; Sequence=VSP_033870, VSP_033871;
CC -!- SIMILARITY: Belongs to the LRRCC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH61202.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=AAH99680.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAH99680.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAB30303.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAD32534.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK173256; BAD32534.1; ALT_INIT; mRNA.
DR EMBL; AK004646; BAB23437.1; -; mRNA.
DR EMBL; AK016559; BAB30303.1; ALT_FRAME; mRNA.
DR EMBL; CH466577; EDL05143.1; -; Genomic_DNA.
DR EMBL; BC061202; AAH61202.1; ALT_SEQ; mRNA.
DR EMBL; BC099680; AAH99680.1; ALT_SEQ; mRNA.
DR EMBL; BC138734; AAI38735.1; -; mRNA.
DR CCDS; CCDS38390.1; -. [Q69ZB0-3]
DR CCDS; CCDS50865.1; -. [Q69ZB0-2]
DR CCDS; CCDS50866.1; -. [Q69ZB0-1]
DR RefSeq; NP_001157051.1; NM_001163579.1.
DR RefSeq; NP_001157052.1; NM_001163580.1.
DR RefSeq; NP_083191.2; NM_028915.3.
DR AlphaFoldDB; Q69ZB0; -.
DR SMR; Q69ZB0; -.
DR BioGRID; 214872; 32.
DR STRING; 10090.ENSMUSP00000126560; -.
DR iPTMnet; Q69ZB0; -.
DR PhosphoSitePlus; Q69ZB0; -.
DR MaxQB; Q69ZB0; -.
DR PaxDb; Q69ZB0; -.
DR PRIDE; Q69ZB0; -.
DR ProteomicsDB; 290161; -. [Q69ZB0-1]
DR ProteomicsDB; 290162; -. [Q69ZB0-2]
DR ProteomicsDB; 290163; -. [Q69ZB0-3]
DR DNASU; 71710; -.
DR GeneID; 71710; -.
DR KEGG; mmu:71710; -.
DR CTD; 85444; -.
DR MGI; MGI:1918960; Lrrcc1.
DR eggNOG; KOG0531; Eukaryota.
DR InParanoid; Q69ZB0; -.
DR OrthoDB; 747731at2759; -.
DR PhylomeDB; Q69ZB0; -.
DR BioGRID-ORCS; 71710; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Lrrcc1; mouse.
DR PRO; PR:Q69ZB0; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q69ZB0; protein.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Leucine-rich repeat; Mitosis; Reference proteome; Repeat.
FT CHAIN 1..1026
FT /note="Leucine-rich repeat and coiled-coil domain-
FT containing protein 1"
FT /id="PRO_0000337082"
FT REPEAT 39..60
FT /note="LRR 1"
FT REPEAT 61..82
FT /note="LRR 2"
FT REPEAT 83..104
FT /note="LRR 3"
FT REPEAT 105..126
FT /note="LRR 4"
FT REPEAT 131..152
FT /note="LRR 5"
FT DOMAIN 170..212
FT /note="LRRCT"
FT REGION 310..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 428..641
FT /evidence="ECO:0000255"
FT COMPBIAS 313..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 286..301
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033869"
FT VAR_SEQ 987..993
FT /note="VQQVEDE -> GDYARGD (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_033870"
FT VAR_SEQ 994..1026
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_033871"
FT CONFLICT 28
FT /note="L -> P (in Ref. 2; BAB30303)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="P -> S (in Ref. 2; BAB23437/BAB30303, 3; EDL05143
FT and 4; AAH61202/AAH99680/AAI38735)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="Q -> K (in Ref. 2; BAB30303)"
FT /evidence="ECO:0000305"
FT CONFLICT 351
FT /note="A -> S (in Ref. 2; BAB23437/BAB30303, 3; EDL05143
FT and 4; AAH61202/AAH99680/AAI38735)"
FT /evidence="ECO:0000305"
FT CONFLICT 530
FT /note="A -> V (in Ref. 4; AAH99680)"
FT /evidence="ECO:0000305"
FT CONFLICT 857
FT /note="S -> P (in Ref. 2; BAB23437)"
FT /evidence="ECO:0000305"
FT CONFLICT 1002
FT /note="C -> S (in Ref. 4; AAH61202)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1026 AA; 119169 MW; A4E69B2A339B880D CRC64;
MEAAVCSEIE REDGDSSCGD VCFMDKGLHS ISELSLDSSI HAINLHCNNI SKISSIDHIW
NLRHLDLSSN QISQIEGLNT LTKLCTLNLS CNLITRVEGL EALVNLTKLN LSYNHINDLS
GLMPLHGLKY KLRYIDLHSN YIDSIHHLLQ CTVGLHFLTN LILEKDGEGN PICLIPGYRA
IILQTLPQLR ILDCKNIFGE PVSLEEINSS HLQCLEGLLD NLVSSDSPLN ISEDEVNDDV
PAPPMDVLPS LKEFKSTPED NVLASLLSVC PSSEPEKINQ ENDFQNEVKL QKLDDQILQL
LNETNNSLID NVPEKDLRPK RDTDITSESD YGNRRECSRK VPRRTKIPYY ARTIQTIKHH
NKNNGAFVSC NRKMRQPYLR DLYVRSSLVN CNNLRDLDEQ KTGVIKVDKN FSDNSTYRSL
VEQLDQEREM RWKAEQTEKK LMDYIDELHK QADEKKDVHS QALITTDRLK DAIFKERHCK
AQLEIIVHRL QNEVKKLTIE LMKARDQQED HIRHLRTLER ALEKMEKQKA QQQAAQIRLI
QEVELKASAA DREINLLRTS LHQEKQQVQQ LHELLALKEQ EHRQEIETRQ FFTDAEFQDA
LTKRLCKEER KHEQEVKEYQ EKIDILNQQY LDLENEFRIA LTVEARRFKD VQDGFEDVAT
ELAKSKHALI WAQRKENESS SLIKDLTCMV KEQKTKLSEV CKLKQEAAAN LQNQINTLEI
LIEDDKQKSI QIELLKHEKT QLISELAAKE SLIYGLRTER KVWGQELACQ SSTLSQSRGK
LEAQIESLCR ENESLRKSHE SDCDALRIKC KIIEDQNETI RKLKDSLQEK DGQIKLLQEQ
IALIEKCSQE QLNEKSSQLD SIVEKLERHN ERKEKLKQQL KAKELELEEI RKAYSTLNKK
WHDKGELLSH LEMQVKEVKE KFEDKERKLK AERDKSLELQ KDAMEKLQNM DDAFRRQVDE
IVEAHQAEIM QLANEKQKYI DCANLKVQQV EDEMRGLLDE TCKNKKMMEE KIKQLACAIS
EIQKEM
