ID   LRCC1_XENLA             Reviewed;        1030 AA.
AC   Q6NRC9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Leucine-rich repeat and coiled-coil domain-containing protein 1;
GN   Name=lrrcc1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the organization of the mitotic spindle.
CC       Maintains the structural integrity of centrosomes during mitosis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LRRCC1 family. {ECO:0000305}.
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DR   EMBL; BC070827; AAH70827.1; -; mRNA.
DR   RefSeq; NP_001084885.1; NM_001091416.1.
DR   AlphaFoldDB; Q6NRC9; -.
DR   SMR; Q6NRC9; -.
DR   DNASU; 431936; -.
DR   GeneID; 431936; -.
DR   KEGG; xla:431936; -.
DR   CTD; 431936; -.
DR   Xenbase; XB-GENE-992691; lrrcc1.L.
DR   OrthoDB; 747731at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 431936; Expressed in egg cell and 16 other tissues.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF12799; LRR_4; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Leucine-rich repeat; Mitosis; Reference proteome; Repeat.
FT   CHAIN           1..1030
FT                   /note="Leucine-rich repeat and coiled-coil domain-
FT                   containing protein 1"
FT                   /id="PRO_0000337083"
FT   REPEAT          7..28
FT                   /note="LRR 1"
FT   REPEAT          29..50
FT                   /note="LRR 2"
FT   REPEAT          51..72
FT                   /note="LRR 3"
FT   REPEAT          73..94
FT                   /note="LRR 4"
FT   REPEAT          95..116
FT                   /note="LRR 5"
FT   REPEAT          121..142
FT                   /note="LRR 6"
FT   DOMAIN          160..200
FT                   /note="LRRCT"
FT   REGION          298..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          432..645
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        300..330
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..365
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1030 AA;  118742 MW;  79688251E723EE7A CRC64;
     MAGTDPRNRE LSLMDKQISS LLEICLNSNL YSINLHCNQI SKIEGLRHLC YLQHLDLSSN
     LITKIEGLDS LASLQSLNLS CNKLTRVEGL EKLFNLKKLN LSYNSIQDLT GLIPLHGWNH
     KLSHLYLHSN CINSIDEVLQ STVGLNCLLH LTLEQNAKGN PVCHALGYRE IILENLPQLN
     SLDGLDRSGD PVTAHEVDSM DLANLDFLEY LITFDSGRKE VKESLTGPVK TARIDEVLTK
     YRKHRDSSEA INLNTDGTSS SEHDVVRFQD NSNMLREMRI KKLEDQISEL LVKASCPKSE
     QTKLKAKRDT DITTESDSES TKENRKGSTT KRTPGCHKTS QTSKQQANQQ LKGRTSYSEL
     KQNVSRKQSL SKRKTDIETS LSSGRTDTDS TGQILGKPHA IGGSLKKKGE LVRNSIEEST
     YRALVQELDQ ERERRWKAEQ VVLKLTENIK ELQSQAKEEK GINSMAVYTT DRIKELLLKE
     KNAKSKLQEL IHHLREENEK LMDELKKLKC KEEDYQKAYK SMEDTLAKLE TQNIQKQALE
     MKQVQETERK VSASQREIDL LRVALRQQKE KVNQLHEVLT SKEQLHRKEL ESRVALNGPE
     FQYALAQEMA KEEHHHSQQI HSFQEKINLL TQQYADLEDE FRAALIIEAE RFKEVKDGFD
     NVASELAEHK ETVHRCRQKE KQSATLMQEL TTMVKEQKAR IAEITKAKQE IISDLKSKIH
     SLEKVAEEGR QKTVQTELLK KEKSKLISQL TAQESLIDGL KAERKIWGQE LTQQGVSLAQ
     DRGRLEAKIE VLSNEIESLK KQNERDADAL RIKTKIVDDQ TETIRKLKEG LQERDERIRK
     LREENIELEK VLQEQSDERT AQLEELKQKL ERQTERKEEV KQLLEEKEAE LEDVKKAYSA
     MNKKWQDKAE LLSHLETQVR QMKENFDAKE NKLIEERDKS LQCQKVITEK LRSVDDAFRR
     QLESVLSAHQ AELIKLASDK QKEIEAANER VYQVEEEMRH LLKETANSKK IMEEKIKRLT
     GALSDIQKEF