ID   LRCH1_FELCA             Reviewed;         251 AA.
AC   P41737;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Leucine-rich repeat and calponin homology domain-containing protein 1;
DE   AltName: Full=Neuronal protein;
DE   Flags: Fragment;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain cortex;
RA   Henschel R.R., Wahle P.;
RL   Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of GTPase CDC42 by sequestering
CC       CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42
CC       activation, negatively regulates CD4(+) T-cell migration.
CC       {ECO:0000250|UniProtKB:Q9Y2L9}.
CC   -!- SUBUNIT: Interacts (via LRR repeats) with unphosphorylated DOCK8 (via
CC       DHR-2 domain); the interaction prevents the interaction between DOCK8
CC       and CDC42. {ECO:0000250|UniProtKB:Q9Y2L9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y2L9}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA56129.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X79682; CAA56129.1; ALT_FRAME; mRNA.
DR   PIR; S47145; S47145.
DR   RefSeq; NP_001041620.1; NM_001048155.1.
DR   AlphaFoldDB; P41737; -.
DR   SMR; P41737; -.
DR   STRING; 9685.ENSFCAP00000020488; -.
DR   GeneID; 727691; -.
DR   KEGG; fca:727691; -.
DR   CTD; 23143; -.
DR   eggNOG; KOG0532; Eukaryota.
DR   HOGENOM; CLU_074728_0_0_1; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:1990869; P:cellular response to chemokine; IBA:GO_Central.
DR   GO; GO:2000405; P:negative regulation of T cell migration; IBA:GO_Central.
DR   CDD; cd00014; CH; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   Pfam; PF00307; CH; 1.
DR   SMART; SM00033; CH; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   PROSITE; PS50021; CH; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           <1..251
FT                   /note="Leucine-rich repeat and calponin homology domain-
FT                   containing protein 1"
FT                   /id="PRO_0000084477"
FT   DOMAIN          131..244
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   REGION          73..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         87
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2L9"
FT   MOD_RES         91
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2L9"
FT   MOD_RES         123
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2L9"
FT   NON_TER         1
SQ   SEQUENCE   251 AA;  28078 MW;  5D5865C76173DB41 CRC64;
     DVDMAMIEQL REAVDLLQDP DRLSTDVSER NVVNFYPVES AEALDLQDSA LNGQIQLETS
     PVCEVQNDLT LQSNGSEYSP NEIRANSPAI SPTANSTGPF GLKPRSVFLR PQRNLESIDP
     QFTIRRKMEQ MREEKELVEH LRESIEMRLK VSLHEDLGAA LMDGVVLCHL VNHIRPRSVA
     SIHVPSPAVP KLSMAKCRRN VENFLEACRK LGVPEEKLCL PHHILEEKGL VKVGITVQAL
     LDVTVTKSLF T