LRCH4_MOUSE
ID LRCH4_MOUSE Reviewed; 680 AA.
AC Q921G6;
DT 21-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Leucine-rich repeat and calponin homology domain-containing protein 4;
GN Name=Lrch4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279; SER-281 AND SER-313, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC012525; AAH12525.1; -; mRNA.
DR CCDS; CCDS19772.1; -.
DR RefSeq; NP_666276.1; NM_146164.2.
DR AlphaFoldDB; Q921G6; -.
DR SMR; Q921G6; -.
DR BioGRID; 231166; 2.
DR STRING; 10090.ENSMUSP00000031734; -.
DR iPTMnet; Q921G6; -.
DR PhosphoSitePlus; Q921G6; -.
DR EPD; Q921G6; -.
DR jPOST; Q921G6; -.
DR MaxQB; Q921G6; -.
DR PaxDb; Q921G6; -.
DR PeptideAtlas; Q921G6; -.
DR PRIDE; Q921G6; -.
DR ProteomicsDB; 292362; -.
DR DNASU; 231798; -.
DR Ensembl; ENSMUST00000031734; ENSMUSP00000031734; ENSMUSG00000093445.
DR Ensembl; ENSMUST00000177545; ENSMUSP00000135286; ENSMUSG00000029720.
DR GeneID; 231798; -.
DR KEGG; mmu:231798; -.
DR CTD; 4034; -.
DR MGI; MGI:1917193; Lrch4.
DR VEuPathDB; HostDB:ENSMUSG00000029720; -.
DR VEuPathDB; HostDB:ENSMUSG00000093445; -.
DR eggNOG; KOG0532; Eukaryota.
DR GeneTree; ENSGT00940000161668; -.
DR HOGENOM; CLU_008231_2_0_1; -.
DR InParanoid; Q921G6; -.
DR OMA; LSTQATY; -.
DR OrthoDB; 378148at2759; -.
DR PhylomeDB; Q921G6; -.
DR TreeFam; TF318428; -.
DR BioGRID-ORCS; 231798; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q921G6; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q921G6; protein.
DR Bgee; ENSMUSG00000029720; Expressed in granulocyte and 57 other tissues.
DR ExpressionAtlas; Q921G6; baseline and differential.
DR Genevisible; Q921G6; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0016605; C:PML body; IDA:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:MGI.
DR CDD; cd00014; CH; 1.
DR Gene3D; 1.10.418.10; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00033; CH; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF47576; SSF47576; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51450; LRR; 7.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..680
FT /note="Leucine-rich repeat and calponin homology domain-
FT containing protein 4"
FT /id="PRO_0000084481"
FT REPEAT 43..64
FT /note="LRR 1"
FT REPEAT 69..90
FT /note="LRR 2"
FT REPEAT 92..114
FT /note="LRR 3"
FT REPEAT 115..136
FT /note="LRR 4"
FT REPEAT 137..158
FT /note="LRR 5"
FT REPEAT 160..182
FT /note="LRR 6"
FT REPEAT 183..205
FT /note="LRR 7"
FT REPEAT 206..226
FT /note="LRR 8"
FT REPEAT 228..249
FT /note="LRR 9"
FT DOMAIN 531..644
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..492
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 279
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 281
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 304
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75427"
FT MOD_RES 307
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75427"
FT MOD_RES 309
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75427"
FT MOD_RES 313
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 432
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75427"
FT MOD_RES 511
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75427"
FT MOD_RES 513
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75427"
FT MOD_RES 517
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75427"
FT MOD_RES 521
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75427"
FT MOD_RES 586
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75427"
SQ SEQUENCE 680 AA; 73163 MW; BE7A0567B346C251 CRC64;
MAAAVAGPLA AGGEEAAASV SLPGSPGLPG SRSAERALEE AVATGTLNLS NRRLKHFPRG
AARSYDLSDI TQADLSRNRF PEVPEAACQL VSLEGLSLYH NCLKCLNPAL GNLTALTYLN
LSRNQLSSLP PYICQLPLRV LIISNNKLGA LPPDISTLGS LRQLDVSSNE LQSLPVELCS
LRSLRDLNVR RNQLSTLPDE LGDLPLVRLD FSCNRISRIP VSFCRLRHLQ VVLLDSNPLQ
SPPAQICLKG KLHIFKYLTM EAGRRGAALG DLVPSRPPSF SPCPAEDLFP GRRYDGGLDS
GFHSVDSGSK RWSGNESTDD FSELSFRISE LARDPRGPRQ PREDGAGDGD LEQIDFIDSH
VPGEDEDRSA AEEQLPSELS LVAGDVEKPS SSRREEPAGE ERRRPDTLQL WQERERKQQQ
QSGGWGSPRK DSVLKRGIRA AGAGASAPST QATCNGPPKS STTQLGVSGG QGAPTPPPTS
QDPLPVSGPV TAPVPRPLGS IQRPNSFLFR SSSQSGSSPS SPESVLRPRP FPQEKELISQ
LRQVLESRLQ QPLPEDLAEA LANGVLLCQL ANQLRPRSVP FIHVPSPAVP KLSALKSRKN
VESFLEACRK MGVPEADLCS PSDLLRGTAQ GLQTVLEAVI LVGGKAPLPV QPSSGLGGFL
LFYVVFMLLL YVVYTRLLGS
