ID   LRCL1_HUMAN             Reviewed;         159 AA.
AC   A6NCL2; H9BFB1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 3.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Leucine-rich colipase-like protein 1;
DE   Flags: Precursor;
GN   Name=LRCOL1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lu Y., Xue Y., Wang P., Ma D.;
RT   "Cloning and identification of a novel human gene LOC100507055.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
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DR   EMBL; JQ012741; AFD01644.1; -; mRNA.
DR   EMBL; AC131212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS73547.1; -.
DR   RefSeq; NP_001182449.1; NM_001195520.1.
DR   AlphaFoldDB; A6NCL2; -.
DR   STRING; 9606.ENSP00000479730; -.
DR   GlyGen; A6NCL2; 1 site.
DR   BioMuta; LRCOL1; -.
DR   MassIVE; A6NCL2; -.
DR   PeptideAtlas; A6NCL2; -.
DR   PRIDE; A6NCL2; -.
DR   DNASU; 100507055; -.
DR   Ensembl; ENST00000376608.9; ENSP00000479730.1; ENSG00000204583.10.
DR   GeneID; 100507055; -.
DR   KEGG; hsa:100507055; -.
DR   MANE-Select; ENST00000376608.9; ENSP00000479730.1; NM_001195520.2; NP_001182449.1.
DR   UCSC; uc021rgr.2; human.
DR   CTD; 100507055; -.
DR   GeneCards; LRCOL1; -.
DR   HGNC; HGNC:44160; LRCOL1.
DR   HPA; ENSG00000204583; Tissue enriched (epididymis).
DR   neXtProt; NX_A6NCL2; -.
DR   OpenTargets; ENSG00000204583; -.
DR   VEuPathDB; HostDB:ENSG00000204583; -.
DR   eggNOG; ENOG502TEXX; Eukaryota.
DR   GeneTree; ENSGT00390000012041; -.
DR   HOGENOM; CLU_140741_0_0_1; -.
DR   InParanoid; A6NCL2; -.
DR   OMA; PQKFCTP; -.
DR   OrthoDB; 1431911at2759; -.
DR   PathwayCommons; A6NCL2; -.
DR   BioGRID-ORCS; 100507055; 6 hits in 189 CRISPR screens.
DR   GenomeRNAi; 100507055; -.
DR   Pharos; A6NCL2; Tdark.
DR   PRO; PR:A6NCL2; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; A6NCL2; protein.
DR   Bgee; ENSG00000204583; Expressed in right lobe of liver and 85 other tissues.
DR   ExpressionAtlas; A6NCL2; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0007586; P:digestion; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   GO; GO:0032094; P:response to food; IBA:GO_Central.
DR   InterPro; IPR001981; Colipase.
DR   PANTHER; PTHR10041; PTHR10041; 1.
DR   Pfam; PF15083; Colipase-like; 2.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..159
FT                   /note="Leucine-rich colipase-like protein 1"
FT                   /id="PRO_0000346758"
FT   CARBOHYD        31
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        7
FT                   /note="T -> M (in Ref. 1; AFD01644)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        42
FT                   /note="R -> G (in Ref. 1; AFD01644)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   159 AA;  17834 MW;  E562F237A53DF599 CRC64;
     MAGPGWTLLL LLLLLLLLGS MAGYGPQKKL NLSHKGIGEP CRRHEECQSN CCTINSLAPH
     TLCTPKTIFL QCLPWRKPNG YRCSHDSECQ SSCCVRNNSP QELCTPQSVF LQCVPWRKPN
     GDFCSSHQEC HSQCCIQLRE YSPFRCIPRT GILAQCLPL