ID   LRCL1_MOUSE             Reviewed;         161 AA.
AC   Q3URS3; B9EJP8; H9C9P1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Leucine-rich colipase-like protein 1;
DE   AltName: Full=Colipase-like protein 3;
DE   Flags: Precursor;
GN   Name=Lrcol1; Synonyms=Clpsl3, Gm1679;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J;
RA   Lu Y., Xue Y.C., Wang P.Z., Ma D.L.;
RT   "Cloning and characterization of the human colipase-like 3 and its homolog
RT   cDNA.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Embryonic stem cell;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3URS3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3URS3-2; Sequence=VSP_044127;
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DR   EMBL; JQ258939; AFE85885.1; -; mRNA.
DR   EMBL; AK141249; BAE24615.1; -; mRNA.
DR   EMBL; BC147447; AAI47448.1; -; mRNA.
DR   EMBL; BC147469; AAI47470.1; -; mRNA.
DR   CCDS; CCDS80364.1; -. [Q3URS3-1]
DR   RefSeq; NP_001297638.1; NM_001310709.1. [Q3URS3-1]
DR   RefSeq; XP_006535095.1; XM_006535032.2. [Q3URS3-1]
DR   AlphaFoldDB; Q3URS3; -.
DR   STRING; 10090.ENSMUSP00000098484; -.
DR   PaxDb; Q3URS3; -.
DR   PRIDE; Q3URS3; -.
DR   ProteomicsDB; 252517; -. [Q3URS3-1]
DR   ProteomicsDB; 252518; -. [Q3URS3-2]
DR   Ensembl; ENSMUST00000100924; ENSMUSP00000098484; ENSMUSG00000072754. [Q3URS3-2]
DR   Ensembl; ENSMUST00000185691; ENSMUSP00000139397; ENSMUSG00000072754. [Q3URS3-1]
DR   GeneID; 381667; -.
DR   KEGG; mmu:381667; -.
DR   UCSC; uc008yqv.1; mouse. [Q3URS3-1]
DR   CTD; 100507055; -.
DR   MGI; MGI:2686525; Lrcol1.
DR   VEuPathDB; HostDB:ENSMUSG00000072754; -.
DR   eggNOG; ENOG502TEXX; Eukaryota.
DR   GeneTree; ENSGT00390000012041; -.
DR   HOGENOM; CLU_140741_0_0_1; -.
DR   InParanoid; Q3URS3; -.
DR   OMA; PQKFCTP; -.
DR   OrthoDB; 1431911at2759; -.
DR   PhylomeDB; Q3URS3; -.
DR   TreeFam; TF352667; -.
DR   BioGRID-ORCS; 381667; 2 hits in 71 CRISPR screens.
DR   PRO; PR:Q3URS3; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q3URS3; protein.
DR   Bgee; ENSMUSG00000072754; Expressed in morula and 5 other tissues.
DR   ExpressionAtlas; Q3URS3; baseline and differential.
DR   Genevisible; Q3URS3; MM.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0007586; P:digestion; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   GO; GO:0032094; P:response to food; IBA:GO_Central.
DR   InterPro; IPR001981; Colipase.
DR   PANTHER; PTHR10041; PTHR10041; 1.
DR   Pfam; PF15083; Colipase-like; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..161
FT                   /note="Leucine-rich colipase-like protein 1"
FT                   /id="PRO_0000346759"
FT   VAR_SEQ         1..39
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:16141072"
FT                   /id="VSP_044127"
SQ   SEQUENCE   161 AA;  18181 MW;  5AD1C65A21338970 CRC64;
     MSVSVWPPLL LLLLLLLLWA VPTFQDKNTR VSAYKGIGEM CRNNSECQSD CCVTNSLNPQ
     KFCTSQTVFL ECVPWRKPNG FLCEENTECH SNCCIRTSSN PDRFCSSKTI FMQCISWRKP
     EGAICQHHLE CWDLCCLPLS ENSPSSHCTK RTGLLALCLP V