LRGA_BACC3
ID LRGA_BACC3 Reviewed; 143 AA.
AC C1ER34;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Antiholin-like protein LrgA {ECO:0000255|HAMAP-Rule:MF_01141};
GN Name=lrgA {ECO:0000255|HAMAP-Rule:MF_01141}; OrderedLocusNames=BCA_5591;
OS Bacillus cereus (strain 03BB102).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=572264;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=03BB102;
RA Dodson R.J., Jackson P., Munk A.C., Brettin T., Bruce D., Detter C.,
RA Tapia R., Han C., Sutton G., Sims D.;
RT "Genome sequence of Bacillus cereus 03BB102.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits the expression or activity of extracellular murein
CC hydrolases by interacting, possibly with LrgB, with the holin-like
CC protein CidA. The LrgAB and CidA proteins may affect the proton motive
CC force of the membrane. May be involved in programmed cell death (PCD),
CC possibly triggering PCD in response to antibiotics and environmental
CC stresses. {ECO:0000255|HAMAP-Rule:MF_01141}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01141};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01141}.
CC -!- SIMILARITY: Belongs to the CidA/LrgA family. LrgA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001407; ACO30300.1; -; Genomic_DNA.
DR RefSeq; WP_000104901.1; NZ_CP009318.1.
DR AlphaFoldDB; C1ER34; -.
DR EnsemblBacteria; ACO30300; ACO30300; BCA_5591.
DR GeneID; 59156929; -.
DR GeneID; 67469691; -.
DR KEGG; bcx:BCA_5591; -.
DR PATRIC; fig|572264.18.peg.18; -.
DR OMA; TGWMTQL; -.
DR Proteomes; UP000002210; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-UniRule.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01141; LrgA; 1.
DR InterPro; IPR023736; Antiholin-like_LrgA.
DR InterPro; IPR005538; LrgA/CidA.
DR PANTHER; PTHR33931; PTHR33931; 1.
DR Pfam; PF03788; LrgA; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytolysis; Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..143
FT /note="Antiholin-like protein LrgA"
FT /id="PRO_1000164098"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01141"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01141"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01141"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01141"
SQ SEQUENCE 143 AA; 15424 MW; 4733BC4315DE5996 CRC64;
MSTKKVYSFL SQAFIFSAIM LISNIIATHL PIPMPSSVIG LVILFSLLCL KVIKLEQVES
LGTALTGIIG FLFVPSGISV INSLGVMGQY FVQILTVIVV ATVILLAVTG LFAQFILGKD
EKETEDTKEL KVVNKGRKHG KVA