LRGA_STAEQ
ID LRGA_STAEQ Reviewed; 152 AA.
AC Q5HLG1;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Antiholin-like protein LrgA {ECO:0000255|HAMAP-Rule:MF_01141};
GN Name=lrgA {ECO:0000255|HAMAP-Rule:MF_01141}; OrderedLocusNames=SERP2026;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Inhibits the expression or activity of extracellular murein
CC hydrolases by interacting, possibly with LrgB, with the holin-like
CC proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the
CC proton motive force of the membrane. May be involved in programmed cell
CC death (PCD), possibly triggering PCD in response to antibiotics and
CC environmental stresses. {ECO:0000255|HAMAP-Rule:MF_01141}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01141};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01141}.
CC -!- SIMILARITY: Belongs to the CidA/LrgA family. LrgA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01141}.
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DR EMBL; CP000029; AAW52844.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5HLG1; -.
DR SMR; Q5HLG1; -.
DR STRING; 176279.SERP2026; -.
DR EnsemblBacteria; AAW52844; AAW52844; SERP2026.
DR KEGG; ser:SERP2026; -.
DR eggNOG; COG1380; Bacteria.
DR HOGENOM; CLU_113736_0_1_9; -.
DR OMA; TGWMTQL; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-UniRule.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01141; LrgA; 1.
DR InterPro; IPR023736; Antiholin-like_LrgA.
DR InterPro; IPR005538; LrgA/CidA.
DR PANTHER; PTHR33931; PTHR33931; 1.
DR Pfam; PF03788; LrgA; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytolysis; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..152
FT /note="Antiholin-like protein LrgA"
FT /id="PRO_0000213198"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01141"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01141"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01141"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01141"
SQ SEQUENCE 152 AA; 16399 MW; C5FBCC40F87FBB26 CRC64;
MVILEQTHLV KNKTVDNKKS MKYSIFQQAL TIAVILLISK IIESFMPIPM PASVIGLVLL
FIALCTGIVK LGQVETVGTA LTNNIGFLFV PAGISVINSL PILKQSPILI ILLIIISTLL
LLICTGFASQ LLVTKSLFPS KEKNEETSHV GG
